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CC BY-NC-ND 4.0 · Sleep Sci 2022; 15(03): 347-350
DOI: 10.5935/1984-0063.20220061
SHORT COMMUNICATIONS

Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice

Bruna Rafaele Diogenes da Silva
1   Federal University of Ceará, Graduate Program in Medical Sciences, Department of Clinical Medicine - Fortaleza - Ceará - Brazil
,
Paulo Iury Gomes Nunes
1   Federal University of Ceará, Graduate Program in Medical Sciences, Department of Clinical Medicine - Fortaleza - Ceará - Brazil
,
Flavia Almeida Santos
2   Federal University of Ceará, Graduate Program in Pharmacology, Department of Physiology and Pharmacology - Fortaleza - Ceará - Brazil
,
Pedro Felipe Carvalhedo de Bruin
1   Federal University of Ceará, Graduate Program in Medical Sciences, Department of Clinical Medicine - Fortaleza - Ceará - Brazil
,
Veralice Meireles Sales de Bruin
1   Federal University of Ceará, Graduate Program in Medical Sciences, Department of Clinical Medicine - Fortaleza - Ceará - Brazil
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Insufficient sleep compromises lipid/glucose homeostasis. In opposition, exercise increases energy expenditure and has positive effects on glucose and fatty acid metabolism. Presently, it is hypothesized that exercise ameliorates metabolic dysfunction associated with sleep deprivation (SD). The effects of exercise (EX), SD and EX before SD. (EX+SD) on lipid and glucose metabolism were evaluated. Swiss mice were assigned to 4 groups (N=12, each) control, exercise (EX, 8 weeks, 1-hour of treadmill/9cm/s, 5x/week, from noon to 1:00 p.m.), SD (SD-72h, multiple platforms method), and exercise before SD (EX+SD). Exercise increased blood glucose, lactate and triglycerides (p<0.05). Both, SD and EX+SD reduced blood triglycerides (p<0.05). EX increased VLDL and reduced LDL; conversely, SD and EX+SD reduced VLDL and increased LDL. Hepatic triglycerides were markedly reduced by SD (p<0.05) and this was prevented by previous exercise (EX+SD). In summary, exercise improved essential cholesterol fractions and exercise before SD increased hepatic cholesterol and prevented hepatic triglycerides depletion.

Sleep Deprivation - Exercise - Glycogen - Lipids - Cholesterol - Liver


Publikationsverlauf

Eingereicht: 14. Juli 2021

Angenommen: 23. Dezember 2021

Artikel online veröffentlicht:
01. Dezember 2023

© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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