PDF herunterladen
CC BY-NC-ND 4.0 · Sleep Sci 2022; 15(03): 363-369
DOI: 10.5935/1984-0063.20220064
REVIEWS

Insomnia in older HIV-positive patients

Cristina Salles
1   Bahiana School of Medicine and Public Health, Salvador - Bahia - Brazil
,
Miguel Meira e Cruz
2   Centro Cardiovascular da Universidade de Lisboa, Lisbon School of Medicine, Sleep Unit - Lisbon - Portugal
,
Igor Cardoso Freire
1   Bahiana School of Medicine and Public Health, Salvador - Bahia - Brazil
,
Lucas Haine Gonzaga
1   Bahiana School of Medicine and Public Health, Salvador - Bahia - Brazil
,
Cristiane Costa Dias
1   Bahiana School of Medicine and Public Health, Salvador - Bahia - Brazil
› Institutsangaben
› Weitere Informationen
Auch verfügbar auf
   Lizenzen und Reprints

Introduction Insomnia is a common sleep disorder in elderly. Although the HIV-positive population have a similar life expectancy when compared to the general population, some factors may interact with immunity conditions and therefore contribute to a worse prognosis.

Objective This is a review of literature that aims to identify prevalence of insomnia in older HIV-positive patients.

Material and Methods This is a review of literature conducted by using MEDLINE-PubMed, Embase, Cochrane Library, CINAHL, Web of Science, Scopus, SciELO, LILACS, and VHL databases, in addition to conducting manual searches. The terms used for the search were related to prevalence, HIV, insomnia, and advanced age. Inclusion criteria were: cross-sectional, cohort, and longitudinal studies, patients with a previous diagnosis of HIV in old age, studies reporting the frequency of insomnia or insomnia symptoms. The criteria for exclusion were: clinical trials, animal studies, letters, abstracts, conference proceedings, studies with other sleep scales that did not include insomnia.

Results There were 2,805 publications found in the database and a further 10 articles were included manually. Of this total, four were included in this review, resulting in a total of 2,227 participants. The prevalence of insomnia in HIV-positive patients over 50 years varied from 12.5% to 76.5%.

Conclusion The frequency of insomnia was higher in the profile of the population studied than in the general population. This should be clinically relevant in order to adequately treat and impact on the prognosis of those patient.

HIV - Sleep Disorders - Aged


Publikationsverlauf

Eingereicht: 13. Juli 2021

Angenommen: 22. November 2021

Artikel online veröffentlicht:
01. Dezember 2023

© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

 

  • REFERENCES

  • 1 Aguiar R, Tavares C, Oliveira W. O vírus da Aids, 20 anos depois [Internet]. Brasília (DF): Ministério da Saúde/FIOCRUZ; 2007; [access in 2019 Jun 03]. Available from: http://www.ioc.fiocruz.br/aids20anos/ linhadotempo.html
  • 2 United Nations Programme on HIV/AIDS (UNAIDS). Estatísticas - UNAIDS Brasil 2019 [Internet]. Brasília (DF): UNAIDS; 2019; [access in 2019 Jun 03]. Available from: https://unaids.org.br/estatisticas/
  • 3 Omonuwa TS, Goforth HW, Preud’homme X, Krystal AD. The pharmacologic management of insomnia in patients with HIV. J Clin Sleep Med. 2009;5(3):251-62.
  • 4 May MT, Gompels M, Delpech V, Porter K, Orkin C, Kegg S, et al. Impact on life expectancy of HIV-1 positive individuals of CD4R cell count and viral load response to antiretroviral therapy. AIDS. 2014 May;28(8):1193-202.
  • 5 Miner B, Kryger MH. Sleep in the aging population. Sleep Med Clin. 2020 Jun;15(2):311-8.
  • 6 Irwin MR, Opp MR. Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology. 2017 Jan;42(1):129-55.
  • 7 Elliot ER, Wang X, Singh S, Simmons B, Vera JH, Miller RF, et al. Increased dolutegravir peak concentrations in people living with human immunodeficiency virus aged 60 and over, and analysis of sleep quality and cognition. Clin Infect Dis. 2019 Jan;68(1):87-95.
  • 8 Jean-Louis G, Weber KM, Aouizerat BE, Levine AM, Maki PM, Liu C, et al. Insomnia symptoms and HIV infection among participants in the women’s interagency HIV study. Sleep. 2012 Jan;35(1):131-7.
  • 9 Ding Y, Lin H, Zhou S, Wang K, Li L, Zhang Y, et al. Stronger association between insomnia symptoms and shorter telomere length in old HIVinfected patients compared with uninfected individuals. Aging Dis. 2018 Dec;9(6):1010-9.
  • 10 Saberi P, Comfort M, Sheon N, Johnson MO. Qualitative study of the quality of sleep in marginalized individuals living with HIV. Patient Prefer Adherence. 2013 Jun;7:499-507.
  • 11 Bhaskar S, Hemavathy D, Prasad S. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Family Med Prim Care. 2016 Oct/Dec;5(4):780-4.
  • 12 Besedovsky L, Lange T, Born J. Sleep and immune function. Pflugers Arch Eur J Physiol. 2012 Jan;463(1):121-37.
  • 13 Jackowska M, Steptoe A. Sleep and future cardiovascular risk: prospective analysis from the English longitudinal study of ageing. Sleep Med. 2015 Jun;16(6):768-74.
  • 14 Poluektov MG. Sleep and immunity. Neurosci Behav Physiol. 2021 Jun;51(5):609-15.
  • 15 Irwin M, McClintick J, Costlow C, Fortner M, White J, Gillin JC. Partial night sleep deprivation reduces natural killer and celhdar immune responses in humans. FASEB J. 1996 Apr;10(5):643-53.
  • 16 Hall MH, Smagula SF, Boudreau RM, Ayonayon HN, Goldman SE, Harris TB, et al. Association between sleep duration and mortality is mediated by markers of inflammation and health in older adults: the health, aging and body composition study. Sleep. 2015 Feb;38(2):189-95.
  • 17 Pérez de Heredia F, Garaulet M, Gómez-Martínez S, Díaz LE, Wärnberg J, Androutsos O, et al. Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study. Sleep Med. 2014 Oct;15(10):1251-8.
  • 18 Smagula SF, Stone KL, Redline S, Ancoli-Israel S, Barrett-Connor E, Lane NE, et al. Actigraphy- and polysomnography-measured sleep disturbances, inflammation, and mortality among older men. Psychosom Med. 2016 Jul/Aug;78(6):686-96.
  • 19 Seay JS, McIntosh R, Fekete EM, Fletcher MA, Kumar M, Schneiderman N, et al. Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV. Psychoneuroendocrinology. 2013 Nov;38(11):2647-53.
  • 20 Jackowska M, Hamer M, Carvalho LA, Erusalimsky JD, Butcher L, Steptoe A. Short sleep duration is associated with shorter telomere length in healthy men: findings from the whitehall II cohort study. PLoS One. 2012;7(10):e47292.
  • 21 Soares CN. Insomnia in women: an overlooked epidemic? Arch Womens Ment Health. 2005 Nov;8(4):205-13.
  • 22 Jaussent I, Dauvilliers Y, Ancelin ML, Dartigues JF, Tavernier B, Touchon J, et al. Insomnia symptoms in older adults: associated factors and gender differences. Am J Geriatr Psychiatry. 2011 Jan;19(1):88-97.
  • 23 Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016 Aug;16(10):626-38.
  • 24 Irwin MR, Olmstead R, Carroll JE. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry. 2016 Jul;80(1):40-52.
  • 25 Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002 Apr;6(2):97-111.
  • 26 Mollayeva T, Thurairajah P, Burton K, Mollayeva S, Shapiro CM, Colantonio A. The Pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: a systematic review and meta-analysis. Sleep Med Rev. 2016 Feb;25:52-73.
  • 27 Park SC, Kim JM, Jun TY, Lee MS, Kim JB, Jeong SH, et al. Prevalence and clinical correlates of insomnia in depressive disorders: the CRESCEND study. Psychiatry Investig. 2013 Dec;10(4):373-81.
  • 28 Uthman OA, Magidson JF, Safren SA, Nachega JB. Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries: a systematic review and meta-analysis. Curr HIV/AIDS Rep. 2014 Sep;11(3):291-307.
  • 29 Low Y, Goforth H, Preud’homme X, Edinger J, Krystal A. Insomnia in HIVinfected patients: pathophysiologic implications. AIDS Rev. 2014;16(1):3-13.
  • 30 Spira AP, Friedman L, Aulakh JS, Lee T, Sheikh JI, Yesavage JA. Subclinical anxiety symptoms, sleep, and daytime dysfunction in older adults with primary insomnia. J Geriatr Psychiatry Neurol. 2008 Jun;21(2):149-53.