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DOI: 10.5935/2526-8732.20190011
Expression of EGFR family and p53 in a patient with Synchronous Primary Endometrial Adenocarcinoma and Clear Cell Renal Carcinoma: a Case Report
Expressão da família EGFR e p53 em paciente com Adenocarcinoma Endometrial e Carcinoma Renal de Células Claras primários e sincrônicos: Relato de Caso
Financial support: CNPq and Fapemig.
ABSTRACT
We present a case of a 69 year-old, non-obese, post-menopausal woman diagnosed with synchronous endometrial adenocarcinoma and renal cell carcinoma. Immunolocalization and expression of the EGFR, HER-2, HER-3, HER-4 and p53 proteins by immunohistochemistry (IHC) was performed to investigate synchronous expression of these proteins. The endometrial adenocarcinoma was a well-differentiated tumor, with discernable glandular structure with moderate mitotic index. IHC revealed weak HER-2, HER-3 and HER-4 staining of cell membranes in well-differentiated areas, and intense HER-2 and p53 staining in papillary areas. The renal cell carcinoma showed clear cell type, solid tumor, Fuhrman nuclear grade 2, presence of necrosis and hemorrhage. IHC revealed intense HER-2 and HER-4 staining of cell membranes, weak EGFR staining, and negative expression for HER3 and p53 protein. In summary, overexpression of HER-2 and HER-4 may correlate with histological grade of the tumor and patient prognosis.
RESUMO
Apresentamos um relato de caso de uma paciente com 69 anos, não-obesa, pós-menopausa, diagnosticada com adenocarcinoma endometrial simultâneo ao carcinoma de células renais. A imunolocalização e expressão das proteínas EGFR, HER-2, HER-3, HER-4 e p53 através de imunohistoquímica (IHC) foi realizada para investigar a simultaneidade na expressão dessas proteínas em ambos tumores. O adenocarcinoma endometrial era um tumor bem diferenciado, com estruturas grandulares discerníveis e com índice mitótico moderado. A IHC revelou fraca marcação das proteínas HER-2, HER-3 e HER-4 nas membranas celulares em áreas bem diferenciadas, e marcação intensa de HER-2 e p53 em áreas papilares. O carcinoma de células renais apresentou tipo células clara, tumor sólido, grau 2 de malignidade nuclear, presença de necrose e hemorragia. IHC revelou marcação intensa de HER-2 e HER-4 nas membranas celulares, fraca de EGFR e negativa para HER-3 e p53. Em resumo, a super expressão das proteínas HER-2 e HER-4 podem estar correlacionadas ao grau histológico dos tumores e ao prognóstico da paciente.
Author's contribution:
H. L. D. P., E. F, F.C.A and A. C. U. conceived and planned the experiments, guided the students, contributed to the interpretation of the results and took the lead in writing the manuscript; I. C. A. S.; P. F. S. M; E. S. V. and T. L. S. carried out the experiment and contributed to the interpretation of the results. All authors provided critical feedback and helped shape the research, analysis and manuscript.
Publication History
Received: 20 February 2018
Accepted: 21 March 2018
Article published online:
11 June 2019
© 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Priscila Fernanda da Silva Martins, Izabella Cristina Alves Souza, Enio Ferreira, Emerson Soares Veloso, Tatiany L Silveira, Adam Underwood, Fabiano Conde Araujo, Helen Lima Del-Puerto. Expression of EGFR family and p53 in a patient with Synchronous Primary Endometrial Adenocarcinoma and Clear Cell Renal Carcinoma: a Case Report. Brazilian Journal of Oncology 2019; 15: e-20190011.
DOI: 10.5935/2526-8732.20190011