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DOI: 10.5935/2526-8732.20190022
Primary lung cancer metastatic to the breast: case report of a patient in remission
Câncer de pulmão primário metastático da mama: relato de caso de paciente em remissão
Financial support: none to declare.
ABSTRACT
While lung carcinoma is the most common of the malignant tumors, primary lung tumors metastatic to the breast are rare and the prognosis is poor. We report a case of a Brazilian, 65- year-old, black, female patient with no family history of breast or lung cancer. During physical gynecological examination, she presented with a palpable nodule in the outer quadrant of the right breast. Based on X-ray, CT, PET-CT and immunohistochemistry investigation, a diagnosis of primary tumor metastatic lung to breast was made. The patient was referred for setorectomy and bi-lobectomy, combined with chemotherapy. She was in remission from November 2012 until December 2018. Given the poor prognosis related to the disease, the evolution presented is surprising.
RESUMO
Embora o carcinoma pulmonar seja o mais comum dos tumores malignos, os tumores primários do pulmão metastáticos da mama são raros e o prognóstico é ruim. Relatamos um caso de uma brasileira, 65 anos, negra, do sexo feminino, sem histórico familiar de câncer de mama ou de pulmão. Durante o exame físico ginecológico, apresentou nódulo palpável no quadrante externo da mama direita. Com base na radiografia, tomografia computadorizada, PET-CT e investigação imunohistoquímica, foi feito o diagnóstico de tumor metastático primário do pulmão à mama. A paciente foi encaminhada para setorectomia e bilobectomia, combinada com quimioterapia. Ela estava em remissão de novembro de 2012 a dezembro de 2018. Dado o mau prognóstico relacionado à doença, a evolução apresentada é surpreendente.
Descritores:
Carcinoma pulmonar de não pequenas células - Metástase neoplásica - Relato de caso - Metástase da mama.AUTHOR'S CONTRIBUTION
Pedro Marchiori Cacilhas: Manuscript writing.
Kelly Mallmann Silva: Manuscript writing.
Monique Wickert: Manuscript writing.
Allan Arrier Azambuja: Manuscript writing.
Publikationsverlauf
Eingereicht: 31. März 2019
Angenommen: 18. August 2019
Artikel online veröffentlicht:
10. September 2019
© 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil
Pedro Marchiori Cacilhas, Kelly Mallmann Silva, Monique Wickert, Allan Arrieira Azambuja. Primary lung cancer metastatic to the breast: case report of a patient in remission. Brazilian Journal of Oncology 2019; 15: e-20190022.
DOI: 10.5935/2526-8732.20190022
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REFERENCES
- Georgiannos S.N.. et al Secondary neoplasms of the breast: a survey of the 20th Century. Cancer 2001; 92 (09) 2259-2266
- Bartella L.. et al Metastases to the breast revisited: radiological-histopathological correlation. Clin Radiol 2003; 58 (07) 524-531
- Toombs B.D., Kalisher L.. Metastatic disease to the breast: clinical, pathologic, and radiographic features. AJR Am J Roentgenol 1977; 129 (04) 673-676
- Alvarado Cabrero I.. et al Metastases to the breast. Eur J Surg Oncol 2003; 29 (10) 854-855
-
[cited 2015 19 de Maio]; Available from: http://www2.inca.gov.br/wps/wcm/connect/tiposdecancer/site/home/pulmao/definicao
- Kimura H.. et al Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-smallcell lung cancer. Clin Cancer Res 2006; 12 (13) 3915-3921
- Herbst R.S.. et al TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005; 23 (25) 5892-5899
- Belani C.P.. et al Quality of life in patients with advanced non-small-cell lung cancer given maintenance treatment with pemetrexed versus placebo (H3E-MC-JMEN): results from a randomised, double-blind, phase 3 study. Lancet Oncol 2012; 13 (03) 292-299
- Paz-Ares L.G.. et al PARAMOUNT: Final overall survival results of the phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer. J Clin Oncol 2013; 31 (23) 2895-2902
- Lee S.H.. et al Metastatic tumors to the breast: mammographic and ultrasonographic findings. J Ultrasound Med 2000; 19 (04) 257-262
- Hajdu S.I., Urban J.A.. Cancers metastatic to the breast. Cancer 1972; 29 (06) 1691-1696
- Surov A.. et al Metastases to the breast from non-mammary malignancies: primary tumors, prevalence, clinical signs, and radiological features. Acad Radiol 2011; 18 (05) 565-574
- Ko K.. et al Micropapillary lung cancer with breast metastasis simulating primary breast cancer due to architectural distortion on images. Korean J Radiol 2012; 13 (02) 249-253
- Ji F.F.. et al Contralateral breast metastasis from pulmonary adenocarcinoma: two cases report and literature review. J Thorac Dis 2012; 4 (04) 384-389
- Bhargava R., Beriwal S., Dabbs D.J.. Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity. Am J Clin Pathol 2007; 127 (01) 103-113
- Camidge D.R.. et al Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 2012; 13 (10) 1011-1019
- Kwak E.L.. et al Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010; 363 (18) 1693-1703