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DOI: 10.5935/2526-8732.20190023
Overview and different perspectives on possible treatments related to NUT carcinoma: a systematic review
Visão geral e perspectivas diferentes sobre possíveis tratamentos relacionados ao carcinoma NUT: uma revisão sistemática.
Financial support: none to declare.
ABSTRACT
NUT carcinoma (midline testicular carcinoma nuclear protein) is a relatively new, rare, aggressive and underdiagnosed entity. Its sites of involvement are medial structures of the head and neck and mediastinum, but other sites may be affected, and even in so-called common structures, the clinical course may impress. The objective of this systematic review was to describe the pathophysiological characteristics of NUT carcinoma and to analyze the types of treatments employed and their efficacy. Throughout the text, treatment - chemotherapy-related forms have been discussed that have led to the complete remission of tumors in some cases, such as the treatment regimen: alternating cycles of vincristine / doxorubicin / ifosfamide and cisplatin / doxorubicin / ifosfamide combined with focal radiotherapy (Scandinavian protocol for inoperable Ewings sarcoma). Other possible future therapies are discussed, in addition to the role of alpha- fetoprotein as a prognostic factor.
RESUMO
O carcinoma NUT (proteína nuclear no carcinoma testicular de linha média) é uma entidade relativamente nova, rara, agressiva e subdiagnosticada. Seus locais de envolvimento são estruturas mediais da cabeça e pescoço e mediastino, mas outros locais podem ser afetados e, mesmo em estruturas comuns, o curso clínico pode impressionar. O objetivo desta revisão sistemática foi descrever as características fisiopatológicas do carcinoma NUT e analisar os tipos de tratamentos empregados e sua eficácia. Ao longo do texto, foram discutidas formas relacionadas ao tratamento quimioterápico que levaram à remissão completa de tumores em alguns casos, como o regime de tratamento: ciclos alternados de vincristina / doxorrubicina / ifosfamida e cisplatina / doxorrubicina / ifosfamida combinados com radioterapia focal (Protocolo escandinavo para sarcoma de Ewings inoperável). Outras possíveis terapias futuras são discutidas, além do papel da alfa-fetoproteína como fator prognóstico.
AUTHOR'S CONTRIBUTION
Antonia Nayra Gomes Lopes: Collection and assembly of data, Conception and design, Data analysis and interpretation, Final approval of manuscript, Manuscript writing, Provision of study materials or patient.
Martinho Hermeson de Matos Furtado: Collection and assembly of data, Data analysis and interpretation, Final approval of manuscript, Manuscript writing, Provision of study materials or patient.
Karen Giselly Paulo Silva: Collection and assembly of data, Data analysis and interpretation, Final approval of manuscript, Provision of study materials or patient.
Lindvaldo de Oliveira Sousa: Collection and assembly of data, Conception and design, Data analysis and interpretation, Final approval of manuscript.
Andrezza Vasconcelos do Vale Aguiar: Collection and assembly of data, Final approval of manuscript, Manuscript writing.
Giovanni Ciarline Silveira: Conception and design, Final approval of manuscript.
Publication History
Received: 14 August 2019
Accepted: 11 November 2019
Article published online:
11 December 2019
© 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil
Antonia Nayra Gomes Lopes, Martinho Hermeson de Matos Furtado, Karen Giselly Paulo Silva, Lindvaldo de Oliveira Sousa, Andrezza Vasconcelos do Vale Aguiar, Giovanni Ciarlini Silveira. Overview and different perspectives on possible treatments related to NUT carcinoma: a systematic review. Brazilian Journal of Oncology 2019; 15: e-20190023.
DOI: 10.5935/2526-8732.20190023
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REFERENCES
- Pathak E., Bhavya D. M., Atri N., Mishra R.. Deciphering the role of microRNAs in BRD4-NUT fusion gene induced NUT midline carcinoma. Bioinformation 2017; 13 (06) 209
- D'Ambrosio L., Palesandro E., Moretti M., Pelosi G., Fabbri A., Schianca F. C., Grignani G.. Alpha-fetoprotein elevation in NUT midline carcinoma: a case report. BMC cancer 2017; 17 (01) 266
- Hellquist H., French C. A., Bishop J. A., CocaPelaz A., Propst E. J., Paiva Correia A., Henrique R.. NUT midline carcinoma of the larynx: an international series and review of the literature. Histopathology 2017; 70 (06) 861-868
- Minato H., Kobayashi E., Nakada S., Kurose N., Tanaka M., Tanaka Y., Nojima T.. Sinonasal NUT carcinoma: clinicopathological and cytogenetic analysis with autopsy findings. Human pathology 2018; 71: 157-165
- Gorospe L., Ayala-Carbonero A. M., Farfán-Leal F. E., Muñoz-Molina G. M., Olmedo-García M. E., Gómez-Rueda A., Garrido-López P.. NUT midline carcinoma causing critical stenosis of the coronary arteries: CT demonstration. Surgery 2018; 163 (02) 480-481
- Kakkar A., Antony V. M., Irugu D. V. K., Adhikari N., Jain D.. NUT midline carcinoma: a series of five cases, including one with unusual clinical course. Head and neck pathology 2018; 12 (02) 230-236
- Lee J. K., Louzada S., An Y., Kim S. Y., Kim S., Youk J., Ku J. L.. Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma. Annals of Oncology 2017; 28 (04) 890-897
- Dickson B. C., Sung Y. S., Rosenblum M. K., Reuter V. E., Harb M., Wunder J. S., Antonescu C. R.. NUTM1 gene fusions characterize a subset of undifferentiated soft tissue and visceral tumors. The American journal of surgical pathology 2018; 42 (05) 636-645
- Boleto G., Perotin J. M., Launois C., Uro-Coste E., Birembaut P., Dury S., Vella-Boucaud J.. Nuclear protein in testis carcinoma of the mediastinum: a case report. Journal of medical case reports 2017; 11 (01) 152
- Dickinson S., Khalil F.. NUT midline carcinoma: a rare malignancy. Cancer Control 2017; 24 (02) 202-206
- Giridhar P., Mallick S., Kashyap L., Rath G. K.. Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases. European Archives of Oto-Rhino-Laryngology 2018; 275 (03) 815-821
- Lemelle L., Pierron G., Fréneaux P., Huybrechts S., Spiegel A., Plantaz D., Le Tourneau C.. NUT carcinoma in children and adults: A multicenter retrospective study. Pediatric blood & cancer 2017; 64 (12) e26693
- Storck S., Kennedy A. L., Marcus K. J., Teot L., Vaughn J., Gnekow A. K., Frühwald M. C.. Pediatric NUT-midline carcinoma: therapeutic success employing a sarcoma based multimodal approach. Pediatric hematology and oncology 2017; 34 (04) 231-237
- Al Diffalha S., Al Aukla N., Hasan Brägelmann J., Dammert M. A., Dietlein F., Heuckmann J. M., Choidas A., Böhm S., Habenberger P.. Systematic kinase inhibitor profiling identifies CDK9 as a synthetic lethal target in NUT midline carcinoma. Cell reports 2017; 20 (12) 28332845
- Vorstenbosch L. J., Mavinkurve -Groothuis A. M., van den Broek G., Flucke U., Janssens G. O.. Long-term survival after relapsed NUT carcinoma of the larynx. Pediatric blood & cancer 2018; 65 (05) e26946