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CC BY 4.0 · Brazilian Journal of Oncology 2021; 17: e-20200047
DOI: 10.5935/2526-8732.20200047
Case Report
Oncological Surgery

Primary breast parenchyma melanoma: case report

Melanoma primário do parênquima da mama: relato de caso

Eduardo Doria  Filho
1   Clínica AMO (Multidisciplinary Oncology Assistance), Skin Cancer Department - Salvador - Bahia - Brazil
,
Gion Aléssio Rocha Brunn
1   Clínica AMO (Multidisciplinary Oncology Assistance), Skin Cancer Department - Salvador - Bahia - Brazil
,
Diego Noya Brandão
2   University of Medicine - UNIFACS, Medicine Course - Salvador - Bahia - Brazil
,
Rafael Silva Ribeiro
1   Clínica AMO (Multidisciplinary Oncology Assistance), Skin Cancer Department - Salvador - Bahia - Brazil
,
Adriano Mata Pires Freire Carvalho
1   Clínica AMO (Multidisciplinary Oncology Assistance), Skin Cancer Department - Salvador - Bahia - Brazil
,
Miguel Ângelo Brandrão
3   Clínica AMO (Multidisciplinary Oncology Assistance), Director of the Skin Cancer Department - Salvador - Bahia - Brazil
› Institutsangaben Financial support: none to declare.
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ABSTRACT

Introduction: Primary breast melanoma is a rare condition and most of cases are associated with melanoma overlying the skin of the breast or metastatic disease site. Primary breast parenchyma melanoma (PBPM) is extremely uncommon with only seven cases reported in the last four decades. Case report: A 44-year-old woman presented with a progressive growth lesion on the right breast in the last 6 months. Initial core biopsy suggested poor differentiated malignant round cells tumor with immunohistochemical confirming melanoma diagnosis. Patient underwent radical modified right mastectomy with final pathological report revealing the diagnosis of PBPM, 10cm x 9cm x 7cm in size. Discussion: After active search on PubMed/MEDLINE database, few case reports were found about PBPM. Radical mastectomy with axillar complete node dissection was the most common initially management. Prognostic was poor in general and only one case presented with no evidence of disease after 1-year follow-up.

RESUMO

Introdução: O melanoma primário da mama é uma condição rara e a maioria dos casos está associada ao melanoma recobrindo a pele da mama ou ao local da doença metastática. O melanoma primário do parênquima da mama (MPPM) é extremamente incomum, com apenas sete casos relatados nas últimas quatro décadas. Relato de caso: Uma mulher de 44 anos apresentou lesão de crescimento progressivo na mama direita nos últimos 6 meses. A biópsia inicial sugeriu tumor de células redondas malignas diferenciadas com diagnóstico imunohistoquímico de melanoma. Paciente foi submetida à mastectomia radical modificada direita com laudo anatomopatológico final revelando o diagnóstico de MPPM, medindo 10cm x 9cm x 7cm. Discussão: Após busca ativa na base de dados PubMed/MEDLINE, foram encontrados poucos relatos de caso sobre MPPM. Mastectomia radical com dissecção completa de nódulo axilar foi o tratamento inicial mais comum. No geral o prognóstico foi ruim e apenas um caso não apresentou evidência da doença após 1 ano de acompanhamento.

Keywords:

Breast neoplasms - Melanoma - Breast diseases.

Descritores:

Neoplasias da mama - Melanoma - Doenças da mama.


Publikationsverlauf

Eingereicht: 02. Dezember 2019

Angenommen: 28. August 2020

Artikel online veröffentlicht:
08. Januar 2021

© 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Thieme Revinter Publicações Ltda.
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Bibliographical Record
Eduardo Doria, Gion Aléssio Rocha Brunn, Diego Noya Brandão, Rafael Silva Ribeiro, Adriano Mata Pires Freire Carvalho, Miguel Ângelo Brandrão. Primary breast parenchyma melanoma: case report. Brazilian Journal of Oncology 2021; 17: e-20200047.
DOI: 10.5935/2526-8732.20200047
 

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