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CC BY 4.0 · Brazilian Journal of Oncology 2021; 17: e-20210022
DOI: 10.5935/2526-8732.20210022
Review Article
Clinical Oncology

COVID-19 and cancer: an extensive review

COVID-19 e câncer: uma revisão extensa

Authors

  • Tomás de Souza Mello

    1   UNESA, Faculdade de Medicina - Rio de Janeiro - Rio de Janeiro - Brazil

  • Rafael Bellotti Azevedo

    1   UNESA, Faculdade de Medicina - Rio de Janeiro - Rio de Janeiro - Brazil

  • João Victor Gonçalves de-Hollanda

    1   UNESA, Faculdade de Medicina - Rio de Janeiro - Rio de Janeiro - Brazil

  • Leonardo Villa Leão Ferreira

    1   UNESA, Faculdade de Medicina - Rio de Janeiro - Rio de Janeiro - Brazil

  • Fabricio Montalvão

    1   UNESA, Faculdade de Medicina - Rio de Janeiro - Rio de Janeiro - Brazil
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ABSTRACT

Emerging data postulates that cancer is an important risk factor for disease severity and higher in-hospital mortality amongst patients with COVID-19. From a pathophysiological perspective, COVID-19 induces an overproduction of inflammatory cytokines, causing systemic inflammation, hypercoagulability, and multiple organ dysfunction syndrome. The exact pathophysiological mechanisms associated with severe COVID-19 disease in patients with cancer is uncertain. Moreover, the challenge of implementing social distancing in patients requiring specific anticancer treatments urged international societies to issue recommendations regarding the adoption of safety measures to reduce transmission risk and optimize anticancer treatment during the COVID-19 pandemic. We provide an extensive review of the clinical outcomes, prognosis and management of patients with cancer and COVID-19 infection.

RESUMO

Dados emergentes postulam que o câncer é um importante fator de risco para gravidade da doença e maior mortalidade hospitalar entre pacientes com COVID-19. Sob uma perspectiva fisiopatológica, a COVID-19 induz uma superprodução de citocinas inflamatórias, causando inflamação sistêmica, hipercoagulabilidade e disfunção de múltiplos órgãos. Os mecanismos fisiopatológicos exatos associados à COVID-19 grave em pacientes com câncer são incertos. Além disso, o desafio de implementar o distanciamento social em pacientes que requerem tratamentos anticâncer específicos instou as sociedades internacionais a emitir recomendações sobre a adoção de medidas de segurança para reduzir o risco de transmissão e otimizar o tratamento anticâncer durante a pandemia de COVID-19. Nós fornecemos uma extensa revisão dos resultados clínicos, prognóstico e tratamento de pacientes com câncer e infecção por COVID-19.

Keywords:

COVID-19 - Cancer - Pathophysiology - Clinical outcome - Management.

Descritores:

Infecções por coronavírus - Sintomas de câncer - Evolução clínica.

CONFLICTS OF INTEREST/DISCLOSURE STATEMENT

The authors declare that there is no conflict of interest.


Financial support: none to declare.


SOURCES OF FUNDING

Fabricio Montalvão had a Researcher fellowship from Universidade Estácio de Sá.




Publikationsverlauf

Eingereicht: 13. April 2021

Angenommen: 13. Juli 2021

Artikel online veröffentlicht:
13. August 2021

© 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

Bibliographical Record
Tomás de Souza Mello, Rafael Bellotti Azevedo, João Victor Gonçalves de-Hollanda, Leonardo Villa Leão Ferreira, Fabricio Montalvão. COVID-19 and cancer: an extensive review. Brazilian Journal of Oncology 2021; 17: e-20210022.
DOI: 10.5935/2526-8732.20210022
 

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