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CC BY 4.0 · Brazilian Journal of Oncology 2021; 17: e-20210027
DOI: 10.5935/2526-8732.20210027
Original Article
Clinical Oncology

Clinicopathological correlation between trophic-adipose levels and poor prognosis outcomes in Brazilian women diagnosed with breast cancer

Correlação clínico-patológica entre níveis trófico-adiposos e desfechos de mau prognóstico em mulheres brasileiras diagnosticadas com câncer de mama
Daniel Rech
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
2   Hospital de Câncer de Francisco Beltrão - Ceonc, Medicine - Francisco Beltrão - PR - Brazil
,
Daniel G Tebaldi
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Jessica Malanowski
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Thalita B Scandolara
3   Universidade Federal do Rio de Janeiro, Genetics - Rio de Janeiro - RJ - Brazil
,
Hellen dos Santos Jaques
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Fernanda Mara Alves
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Gessica T Teixeira
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Janaína Carla da Silva
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Maria Eduarda Vasselai
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Juliana B Moura
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Rayana T Damo
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Carolina Panis
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
› Author Affiliations Financial support: Fundação Araucária, Programa de Pesquisa para o SUS.
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ABSTRACT

Objective: To describe the clinicopathological profile of breast cancer patients and association with excess body weight.

Methods: This was a descriptive observational study of 126 women with breast cancer lesions treated between 2015 and 2017 at a cancer referral hospital for 27 municipalities in southwestern Paraná. Patients were categorized according to age at diagnosis, body mass index, menopausal status, molecular subtyping of tumors, histological characteristics, and risk stratification. Data were coded for analysis using the Statistical Package for Social Sciences (SPSS) 22.0.0 software.

Results: There were 126 patients diagnosed with breast cancer and more than half of these had an excessive body weight (mean BMI 27.5kg/m2). There was a predominance of the triple negative molecular subtype in overweight women; they also had a higher frequency of tumors larger than 2cm and high histological grade tumors. There were significant associations in the overweight/ obese subgroup such as tumors in the intermediate grade luminal B subtype, presence of angiolymphatic emboli, and a high-risk of disease recurrence.

Conclusion: The data indicate that being overweight is a determinant of worse prognosis in women with breast cancer in southwestern Paraná.

RESUMO

Objetivo: Descrever o perfil clínico-patológico de pacientes com câncer de mama e sua associação com o excesso de peso corporal.

Métodos: Trata-se de um estudo observacional descritivo com 126 mulheres com lesões de câncer de mama atendidas entre 2015 e 2017 em um hospital referência em câncer de 27 municípios do sudoeste do Paraná. Os pacientes foram classificados de acordo com a idade ao diagnóstico, índice de massa corporal, estado da menopausa, subtipagem molecular de tumores, características histológicas e estratificação de risco. Os dados foram codificados para análise por meio do software Statistical Package for Social Sciences (SPSS) 22.0.0.

Resultados: Foram 126 pacientes com diagnóstico de câncer de mama e mais da metade delas apresentava peso corporal excessivo (IMC médio de 27,5kg/m2). Houve predomínio do subtipo molecular triplo negativo em mulheres com sobrepeso; também apresentaram maior frequência de tumores maiores que 2cm e tumores de alto grau histológico. Houve associações significativas no subgrupo com sobrepeso/obesidade, como tumores no subtipo luminal B de grau intermediário, presença de êmbolos angiolinfáticos e um alto risco de recorrência da doença.

Conclusão: Os dados indicam que o excesso de peso é um determinante de pior prognóstico em mulheres com câncer de mama no sudoeste do Paraná.

Keywords:

Breast neoplasms - Obesity - Prognosis.

Descritores:

Neoplasias mamárias - Obesidade - Prognóstico.

Conflict of Interests

The authors have no conflicts to declare.




Publication History

Received: 19 February 2021

Accepted: 19 August 2021

Article published online:
24 September 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Daniel Rech, Daniel G Tebaldi, Jessica Malanowski, Thalita B Scandolara, Hellen dos Santos Jaques, Fernanda Mara Alves, Gessica T Teixeira, Janaína Carla da Silva, Maria Eduarda Vasselai, Juliana B Moura, Rayana T Damo, Carolina Panis. Clinicopathological correlation between trophic-adipose levels and poor prognosis outcomes in Brazilian women diagnosed with breast cancer. Brazilian Journal of Oncology 2021; 17: e-20210027.
DOI: 10.5935/2526-8732.20210027
 

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