CC BY 4.0 · Brazilian Journal of Oncology 2021; 17: e-20210027
DOI: 10.5935/2526-8732.20210027
Original Article
Clinical Oncology

Clinicopathological correlation between trophic-adipose levels and poor prognosis outcomes in Brazilian women diagnosed with breast cancer

Correlação clínico-patológica entre níveis trófico-adiposos e desfechos de mau prognóstico em mulheres brasileiras diagnosticadas com câncer de mama
Daniel Rech
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
2   Hospital de Câncer de Francisco Beltrão - Ceonc, Medicine - Francisco Beltrão - PR - Brazil
,
Daniel G Tebaldi
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Jessica Malanowski
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Thalita B Scandolara
3   Universidade Federal do Rio de Janeiro, Genetics - Rio de Janeiro - RJ - Brazil
,
Hellen dos Santos Jaques
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Fernanda Mara Alves
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Gessica T Teixeira
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Janaína Carla da Silva
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Maria Eduarda Vasselai
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Juliana B Moura
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Rayana T Damo
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
,
Carolina Panis
1   State University of West Paraná, CCS - Francisco Beltrão - PR - Brazil
› Author Affiliations
Financial support: Fundação Araucária, Programa de Pesquisa para o SUS.

ABSTRACT

Objective: To describe the clinicopathological profile of breast cancer patients and association with excess body weight.

Methods: This was a descriptive observational study of 126 women with breast cancer lesions treated between 2015 and 2017 at a cancer referral hospital for 27 municipalities in southwestern Paraná. Patients were categorized according to age at diagnosis, body mass index, menopausal status, molecular subtyping of tumors, histological characteristics, and risk stratification. Data were coded for analysis using the Statistical Package for Social Sciences (SPSS) 22.0.0 software.

Results: There were 126 patients diagnosed with breast cancer and more than half of these had an excessive body weight (mean BMI 27.5kg/m2). There was a predominance of the triple negative molecular subtype in overweight women; they also had a higher frequency of tumors larger than 2cm and high histological grade tumors. There were significant associations in the overweight/ obese subgroup such as tumors in the intermediate grade luminal B subtype, presence of angiolymphatic emboli, and a high-risk of disease recurrence.

Conclusion: The data indicate that being overweight is a determinant of worse prognosis in women with breast cancer in southwestern Paraná.

RESUMO

Objetivo: Descrever o perfil clínico-patológico de pacientes com câncer de mama e sua associação com o excesso de peso corporal.

Métodos: Trata-se de um estudo observacional descritivo com 126 mulheres com lesões de câncer de mama atendidas entre 2015 e 2017 em um hospital referência em câncer de 27 municípios do sudoeste do Paraná. Os pacientes foram classificados de acordo com a idade ao diagnóstico, índice de massa corporal, estado da menopausa, subtipagem molecular de tumores, características histológicas e estratificação de risco. Os dados foram codificados para análise por meio do software Statistical Package for Social Sciences (SPSS) 22.0.0.

Resultados: Foram 126 pacientes com diagnóstico de câncer de mama e mais da metade delas apresentava peso corporal excessivo (IMC médio de 27,5kg/m2). Houve predomínio do subtipo molecular triplo negativo em mulheres com sobrepeso; também apresentaram maior frequência de tumores maiores que 2cm e tumores de alto grau histológico. Houve associações significativas no subgrupo com sobrepeso/obesidade, como tumores no subtipo luminal B de grau intermediário, presença de êmbolos angiolinfáticos e um alto risco de recorrência da doença.

Conclusão: Os dados indicam que o excesso de peso é um determinante de pior prognóstico em mulheres com câncer de mama no sudoeste do Paraná.

Conflict of Interests

The authors have no conflicts to declare.




Publication History

Received: 19 February 2021

Accepted: 19 August 2021

Article published online:
24 September 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

Bibliographical Record
Daniel Rech, Daniel G Tebaldi, Jessica Malanowski, Thalita B Scandolara, Hellen dos Santos Jaques, Fernanda Mara Alves, Gessica T Teixeira, Janaína Carla da Silva, Maria Eduarda Vasselai, Juliana B Moura, Rayana T Damo, Carolina Panis. Clinicopathological correlation between trophic-adipose levels and poor prognosis outcomes in Brazilian women diagnosed with breast cancer. Brazilian Journal of Oncology 2021; 17: e-20210027.
DOI: 10.5935/2526-8732.20210027
 
  • REFERENCES

  • 1 Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal Al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; Nov; 68 (06) 394-424
  • 2 Winters S, Martin C, Murphy D, Shokar NK. Breast cancer epidemiology, prevention, and screening. Prog Mol Biol Transl Sci 2017; 151: 1-32
  • 3 Borghesan DH, Agnolo CM, Gravena AA, Demitto MO, Lopes TC, Carvalho MD. et al. Risk factors for breast cancer in postmenopausal women in Brazil. Asian Pac J Cancer Prev 2016; 17 (07) 3587-3593
  • 4 Gravena AA, Lopes TCR, Demitto MO, Borghesan DH, Dell'Agnolo CM, Brischiliari SC. et al. The obesity and the risk of breast cancer among pre and postmenopausal women. Asian Pac J Cancer Prev 2018; Sep; 19 (09) 2429-2436
  • 5 Jerônimo AF, Weller M. Differential association of the lifestyle-related risk factors smoking and obesity with triple negative breast cancer in a Brazilian population. Asian Pac J Cancer Prev 2017; 18 (06) 1585-1593
  • 6 Kops NL, Bessel M, Caleffi M, Ribeiro RA, Wendland EM. Body weight and breast cancer: nested case-control study in southern Brazil. Clin Breast Cancer 2018; 18 (05) e797-803
  • 7 Cormanique TF, Almeida LEDE, Rech CA, Rech D, Herrera ACSA, Panis C. Chronic psychological stress and its impact on the development of aggressive breast cancer. Einstein (São Paulo) 2015; Jul/Sep; 13 (03) 352-356
  • 8 Picon-Ruiz M, Morata-Tarifa C, Valle-Goffin JJ, Friedman ER, Slingerland JM. Obesity and adverse breast cancer risk and outcome: mechanistic insights and strategies for intervention. CA Cancer J Clin 2017; Sep; 67 (05) 378-397
  • 9 Quiroga-Morales LA, Sat-Muñoz D, MartínezHerrera BE, Alcántara-Cadillo RR, Macías-López GG, García-Cobián TA. et al. Obesity and adipocytokines in breast cancer and benign breast disease. Rev Med Inst Mex Seguro Soc 2018; 56 (03) 246-254
  • 10 Panis C, Herrera ACSA, Aranome AMF, Victorino VJ, Michelleti PL, Morimoto HK. et al. Clinical insights from adiponectin analysis in breast cancer patients reveal its anti-inflammatory properties in non-obese women. Mol Cell Endocrinol 2014; Jan; 382 (01) 190-196
  • 11 Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; Apr; 348 (17) 1625-1638
  • 12 Warner ET, Ballman KV, Strand C, Boughey JC, Buzdar AU, Carey LA. et al. Impact of race, ethnicity, and BMI on achievement of pathologic complete response following neoadjuvant chemotherapy for breast cancer: a pooled analysis of four prospective alliance clinical trials (A151426). Breast Cancer Res Treat 2016; Aug; 159 (01) 109-118
  • 13 Jones T, McCarthy AM, Kim Y, Armstrong K. Predictors of BRCA1/2 genetic testing among Black women with breast cancer: a populationbased study. Cancer Med 2017; Jul; 6 (07) 1787-1798
  • 14 Vaysse C, Lømo J, Garred Ø, Fjeldheim F, Lofteroed T, Schlichting E. et al. Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer. NPJ Breast Cancer 2017; 3: 19
  • 15 Zahid H, Simpson ER, Brown KA. Inflammation, dysregulated metabolism, and aromatase in obesity and breast cancer. Curr Opin Pharmacol 2016; Dec; 31: 90-96
  • 16 Hillers LE, D'Amato JV, Chamberlin T, Paderta G, Arendt LM. Obesity-activated adipose-derived stromal cells promote breast cancer growth and invasion. Neoplasia 2018; Nov; 20 (11) 1161-1174
  • 17 Khabaz MN, Abdelrahman A, Butt N, Damnhory L, Elshal M, Aldahlawi AM. et al. Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer. BMC Womens Health 2017; Nov; 17 (01) 105
  • 18 Bowers LW, Rossi EL, McDonell SB, Doerstling SS, Khatib SA, Lineberger CG. et al. Leptin signaling mediates obesity-associated CSC enrichment and EMT in preclinical TNBC models. Mol Cancer Res 2018; May; 16 (05) 869-879
  • 19 Borgquist S, Wirfält E, Jirström K, Anagnostaki L, Gullberg B, Berglund G. et al. Diet and body constitution in relation to subgroups of breast cancer defined by tumor grade, proliferation and key cell cycle regulators. Breast Cancer Res 2007; 9 (01) R11
  • 20 Gonzalez-Guerrico AM, Espinoza I, Schroeder B, Park CH, Kvp CM, Khurana A. et al. Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer. Oncotarget 2016; Nov; 7 (44) 71151-68
  • 21 Hasebe T, Yamauchi C, Iwasaki M, Ishii G, Wada N, Imoto S. Grading system for lymph vessel tumor emboli for prediction of the outcome of invasive ductal carcinoma of the breast. Hum Pathol 2008; Apr; 39 (03) 427-436
  • 22 Rubio-Jurado B, Balderas-Peña LM, GarcíaLuna EE, Zavala-Cerna MG, Riebeling-Navarro C, Reyes PA. et al. Obesity, thrombotic risk and inflammation in cancer. Adv Clin Chem 2018; 85: 71-89