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CC BY 4.0 · Brazilian Journal of Oncology 2022; 18: e-20220289
DOI: 10.5935/2526-8732.20220289
Case Report
Oncological Surgery

Dermatofibrosarcoma: report of a case with complete response to imatinib and conservative surgery during the COVID-19 pandemic

Dermatofibrossarcoma: relato de um caso com resposta completa ao imatinibe e cirurgia conservadora durante a pandemia de COVID-19
Rafael Martins Steffen
1   Faculdade de Medicina do ABC, Cirurgia Oncológica - Santo André - SP - Brazil
,
Arthur Fernandes Pacheco
1   Faculdade de Medicina do ABC, Cirurgia Oncológica - Santo André - SP - Brazil
,
Gabriela Camilo Teixeira
1   Faculdade de Medicina do ABC, Cirurgia Oncológica - Santo André - SP - Brazil
,
Bruna Alejandra Orellana Santos
1   Faculdade de Medicina do ABC, Cirurgia Oncológica - Santo André - SP - Brazil
,
Marina Quaglio Oinegue Fulfaro
1   Faculdade de Medicina do ABC, Cirurgia Oncológica - Santo André - SP - Brazil
,
Ketleen Koga
1   Faculdade de Medicina do ABC, Cirurgia Oncológica - Santo André - SP - Brazil
,
Amanda Fonseca Nunes Ferreira
1   Faculdade de Medicina do ABC, Cirurgia Oncológica - Santo André - SP - Brazil
,
James Cotaet Junior
2   Faculdade de Medicina do ABC, Patologia - Santo André - SP - Brazil
,
Deborah Krutman Zveibil
2   Faculdade de Medicina do ABC, Patologia - Santo André - SP - Brazil
,
Rafael Ricardo da Silva Miranda Zapata
3   Faculdade de Medicina do ABC, Oncologia Clínica - Santo André - SP - Brazil
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Financial support: None to declare.
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ABSTRACT

Dermatofibrosarcoma protuberans (DFSP) is an extremely rare and potentially aggressive soft tissue tumor. Around 85 to 90% of DFSP cases are low-grade tumors, while the fibrosarcomatous variant (DFSP-FS) is associated with medium and high-grade neoplasms. DFSP affects more young adults, in their 30s; however, it can be present in all ages. It has a high potential for locoregional dissemination and recurrence, directly related to tumor size. In the present study, a case of dermatofibrosarcoma protuberans with local recurrence after surgical treatment will be reported, subsequently treated with imatinib and a new surgical approach, with no new recurrences so far. The effectiveness of imatinib is noted in a deep, infiltrative and relapsed DFSP, in which upfront surgery would cause significant functional and cosmetic damage. Imatinib allowed an important clinical improvement for the patient, with tumor reduction in the initial weeks of treatment.

Keywords:

Dermatofibrosarcoma - Imatinib mesylate - Complementary therapies


Publication History

Received: 18 July 2021

Accepted: 31 August 2021

Article published online:
09 March 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Rafael Martins Steffen, Arthur Fernandes Pacheco, Gabriela Camilo Teixeira, Bruna Alejandra Orellana Santos, Marina Quaglio Oinegue Fulfaro, Ketleen Koga, Amanda Fonseca Nunes Ferreira, James Cotaet, Deborah Krutman Zveibil, Rafael Ricardo da Silva Miranda Zapata. Dermatofibrosarcoma: report of a case with complete response to imatinib and conservative surgery during the COVID-19 pandemic. Brazilian Journal of Oncology 2022; 18: e-20220289.
DOI: 10.5935/2526-8732.20220289
 

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