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CC BY 4.0 · Brazilian Journal of Oncology 2022; 18: e-20220329
DOI: 10.5935/2526-8732.20220329
Case Report
Surgical Oncology

Initial experience of irreversible electroporation ablation in Brazil: a retrospective analysis

Experiência inicial de ablação por eletroporação irreversível no Brasil: uma análise retrospectiva
Daniel Takeshi Setuguti
1   Rede D'Or, Interventional radiology - São Paulo - SP - Brazil
,
Daniel Simões Oliveira
1   Rede D'Or, Interventional radiology - São Paulo - SP - Brazil
,
Grace Gadelha Martins
1   Rede D'Or, Interventional radiology - São Paulo - SP - Brazil
,
Oddone Freitas Melro Braghiroli
2   Rede D'Or, Surgery - São Paulo - SP - Brazil
,
Antonio Luiz Vaconcellos Macedo
2   Rede D'Or, Surgery - São Paulo - SP - Brazil
,
Luiz Tenorio de Brito Siqueira
1   Rede D'Or, Interventional radiology - São Paulo - SP - Brazil
› Author Affiliations Financial support: None to declare.
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ABSTRACT

Introduction: The objective of our study is to present the first Brazilian irreversible electroporation experience in the treatment of solid cancer.

Material and Methods: A retrospective study with the first ten patients who underwent percutaneous or surgical IRE to treat solid cancer between March 2021 and May 2021. Preoperative data collection included patient demographics along with previous oncologic treatments. Operative and post-operative assessment involved number of probes, number of pulses, initial and final current and 30-days complications.

Results: Primary tumor was locally advanced pancreatic cancer (70%), colorectal hepatic metastasis (20%), and cholangiocarcinoma (10%). All patients had previously undergone chemotherapy with stable disease in 80% and partial response in 20% before IRE. Eighty percent of the procedures was performed surgically and 20% percutaneously CT-guided. The mean procedure time of IRE was 38 minutes. Adverse events occurred in 4 patients (40%), all being grade I-II complications.

RESUMO

Introdução: O objetivo do nosso estudo é apresentar a primeira experiência brasileira de eletroporação irreversível no tratamento de câncer sólido.

Material e Métodos: Estudo retrospectivo com os dez primeiros pacientes submetidos à IRE percutânea ou cirúrgica para tratamento de câncer sólido entre março de 2021 e maio de 2021. A coleta de dados pré-operatórios incluiu dados demográficos dos pacientes juntamente com tratamentos oncológicos anteriores. A avaliação operatória e pós-operatória envolveu número de sondas, número de pulsos, corrente inicial e final e complicações em 30 dias.

Resultados: Tumor primário foi câncer de pâncreas localmente avançado (70%), metástase hepática colorretal (20%) e colangiocarcinoma (10%). Todos os pacientes haviam sido submetidos à quimioterapia previamente com doença estável em 80% e resposta parcial em 20% antes da IRE. Oitenta por cento dos procedimentos foram realizados cirurgicamente e 20% guiados por TC percutânea. O tempo médio de procedimento de IRE foi de 38 minutos. Eventos adversos ocorreram em 4 pacientes (40%), todos sendo complicações grau I-II.

Keywords:

Radiology, Interventional - Ablation techniques - Pancreatic neoplasms - Liver neoplasms

Descritores:

Radiologia intervencionista - Técnicas de ablação - Neoplasias pancreáticas - Neoplasias hepáticas


Publication History

Received: 13 January 2022

Accepted: 11 August 2022

Article published online:
06 October 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Daniel Takeshi Setuguti, Daniel Simões Oliveira, Grace Gadelha Martins, Oddone Freitas Melro Braghiroli, Antonio Luiz Vaconcellos Macedo, Luiz Tenorio de Brito Siqueira. Initial experience of irreversible electroporation ablation in Brazil: a retrospective analysis. Brazilian Journal of Oncology 2022; 18: e-20220329.
DOI: 10.5935/2526-8732.20220329
 

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