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DOI: 10.5935/2526-8732.20220348
Assessment of body mass index and its relationship with breast cancer survival in a clinical oncology service in the Federal District
Avaliação do índice de massa corporal e sua relação com a sobrevida ao câncer de mama em um serviço de oncologia clínica do Distrito Federal Financial support: None to declare.
ABSTRACT
Objective: The purpose of this study was to analyze the relationship between obesity and clinical outcomes in breast cancer patients by evaluating the mean body mass index (BMI) and overall survival.
Material and Methods: The research's method consisted of a retrospective observational and descriptive study without intervention, carried out in a public oncology service in Brazils Federal District. We selected breast cancer patients with hormonal expression positivity in follow-up from January 2016 to December 2020.
Results: 305 female patients were evaluated, aged between 33 and 92 years old (average age of 59). Most patients were over 55 years old (63.3%). The mean weight of the patients was 71.70±9.10 kilograms. Regarding BMI, 38.7% of patients were classified as obese. As for the immunohistochemical classification (IHC), 72.9% of the patients were luminal B. Among the patients in which the initial treatment was registered, 56.1% received hormone therapy, while 43.9% received chemotherapy. The intention to treat in most patients was curative. Most patients had disease staging between II and III. As for the outcome, most patients were still undergoing treatment (83.0%) at the time of data collection. Correlating the IHC classification with patient survival, there was no significant difference between patient's classified as luminal A and those classified as luminal B (p: 0.342). There was also no significant difference between non-obese and obese patients in the assessment of overall survival and weight (p: 0.917).
Conclusion: Despite the high prevalence of obesity in the studied population, the overall survival of this group did not differ from the non-obese group, even in the analyzes by IHC profile.
RESUMO
Objetivo: O objetivo deste estudo foi analisar a relação entre obesidade e desfechos clínicos em pacientes com câncer de mama, avaliando o índice de massa corporal (IMC) médio e a sobrevida global.
Material e Métodos: O método da pesquisa consistiu em um estudo observacional retrospectivo e descritivo sem intervenção, realizado em um serviço público de oncologia do Distrito Federal. Selecionamos pacientes com câncer de mama com positividade de expressão hormonal em acompanhamento de janeiro de 2016 a dezembro de 2020.
Resultados: Foram avaliadas 305 pacientes do sexo feminino, com idade entre 33 e 92 anos (idade média de 59). A maioria dos pacientes tinha mais de 55 anos (63,3%). O peso médio dos pacientes foi de 71,70±9,10kg. Em relação ao IMC, 38,7% dos pacientes foram classificados como obesos. Quanto à classificação imuno-histoquímica (IHQ), 72,9% dos pacientes eram luminal B. Entre os pacientes em que o tratamento inicial foi registrado, 56,1% receberam terapia hormonal, enquanto 43,9% receberam quimioterapia. A intenção de tratar na maioria dos pacientes foi curativa. A maioria dos pacientes apresentou estadiamento da doença entre II e III. Quanto ao desfecho, a maioria dos pacientes ainda estava em tratamento (83,0%) no momento da coleta de dados. Correlacionando a classificação do IHQ com a sobrevida do paciente, não houve diferença significativa entre os pacientes classificados como luminal tipo A e os classificados como luminal tipo B (p: 0,342). Também não houve diferença significativa entre pacientes não obesos e obesos na avaliação da sobrevida global e peso (p: 0,917).
Conclusão: Apesar da alta prevalência de obesidade na população estudada, a sobrevida global deste grupo não diferiu do grupo não obeso, mesmo nas análises por perfil IHC.
Publication History
Received: 25 April 2022
Accepted: 19 August 2022
Article published online:
06 October 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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Kamila Fernandes Ferreira, Luiza Nardin Weis, Leandro Almeida Assunção, Eduarda Sabá Cordeiro de Oliveira, Rafael Amaral de Castro. Assessment of body mass index and its relationship with breast cancer survival in a clinical oncology service in the Federal District. Brazilian Journal of Oncology 2022; 18: e-20220348.
DOI: 10.5935/2526-8732.20220348
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