Abscess-like postpartum metaplastic breast carcinoma in breastfeeding woman: a case report

ABSTRACT

Introduction: Breast cancer diagnosed within 10 years of parturition is named postpartum breast cancer which is a highly metastatic tumor with poor prognosis.

Case Report: A 31-year-old female presented with fever and painful mass in the left breast. She had undergone C-section 6 months ago of her second child. A left breast biopsy was performed and showed estrogen receptor-negative, progesterone receptor-negative, and human epidermal growth factor receptor 2 (HER2) negative invasive highly differentiated carcinoma. A radical mastectomy and left axillary lymphadenectomy were then performed and the anatomopathological report showed a 16cm metaplastic breast carcinoma. Eight months after the start of the chemotherapy treatment, the patient was diagnosed with brain metastases.

Discussion: Postpartum breast cancer is associated with worse survival rates presenting increased risk of death. Metaplastic breast carcinoma is a subtype of triple-negative breast cancer also associated with poor prognosis and chemotherapy treatment resistant, being surgery the standard treatment.

RESUMO

Introdução: O câncer de mama diagnosticado até 10 anos depois do parto é chamado câncer de mama pós-parto, um tipo altamente metastático e com mau prognóstico.

Relato de Caso: Mulher, 31 anos, se apresentou com febre e uma massa hiperêmica e dolorosa na mama esquerda. Ela havia passado por uma cesárea seis meses antes de seu segundo filho. Foi realizada uma biópsia na mama esquerda e a análise histológica e imunoistoquímica mostrou um carcinoma altamente diferenciado negativo para receptor de estrógeno, de progesterona e do fator de crescimento epidermal humano 2 (HER2). Mastectomia radical e linfadenectomia axilar esquerda foram realizadas e a análise anatomopatológica indicou um carcinoma metaplásico de mama de 16 cm. Oito meses depois do início da quimioterapia, a paciente foi diagnosticada com metástase cerebral.

Discussão: O câncer de mama pós-parto é associado a taxas ruins de sobrevida apresentando de duas a três vezes mais risco de morte. O câncer de mama metaplásico é também associado a um prognóstico ruim e a resistência ao tratamento quimioterápico, sendo a cirurgia o tratamento padrão.

Keywords:

Lymphatic metastasis - Triple negative breast neoplasms - Inflammatory breast neoplasms

Descritores:

Metástase linfática - Neoplasias mamárias triplo negativas - Neoplasias inflamatórias da mama

Publikationsverlauf

Eingereicht: 27. Oktober 2022

Angenommen: 13. Januar 2023

Artikel online veröffentlicht:
02. Februar 2023

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