CC BY 4.0 · Brazilian Journal of Oncology 2023; 19: e-20230406
DOI: 10.5935/2526-8732.20230406
Case Report
Clinical Oncology

Non-bacterial thrombotic endocarditis: a case report with favorable evolution and literature review

Endocardite trombótica não bacteriana: relato de caso com evolução favorável e revisão da literatura
1   Hospital de Clínicas de Passo Fundo, Oncology, Passo Fundo - Rio Grande do Sul, Brazil
,
1   Hospital de Clínicas de Passo Fundo, Oncology, Passo Fundo - Rio Grande do Sul, Brazil
,
1   Hospital de Clínicas de Passo Fundo, Oncology, Passo Fundo - Rio Grande do Sul, Brazil
› Author Affiliations
Financial support: None to declare.

ABSTRACT

Nonbacterial thrombotic endocarditis is an uncommon disease characterized by formation and deposition of sterile fibrin vegetations on heart valves. This condition is more related to states of chronic inflammation, mainly related to malignancy. This report describes the case of a Brazilian woman, 50 years old, smoker, diagnosed with pulmonary adenocarcinoma with pleural and bone metastases after presenting with deep venous thrombosis and pulmonary embolism. During the investigation, a transthoracic echocardiogram was performed, which revealed a mobile echogenic mass in the mitral leaflet. As there were no suggestive signs or laboratory tests that corroborated a systemic bacterial infection, the diagnosis of non-bacterial thrombotic endocarditis was confirmed. Given the poor prognosis related to the disease, suspicion and early treatment were determining factors for the favorable evolution presented.

RESUMO

A endocardite trombótica não bacteriana é uma doença incomum caracterizada pela formação e deposição de vegetações estéreis de fibrina nas válvulas cardíacas. Essa condição está mais relacionada a estados de inflamação crônica, principalmente relacionados à malignidade. Este relato descreve o caso de uma mulher brasileira, 50 anos, tabagista, diagnosticada com adenocarcinoma pulmonar com metástases pleurais e ósseas após apresentar trombose venosa profunda e embolia pulmonar. Durante a investigação, foi realizado ecocardiograma transtorácico, que revelou massa ecogênica móvel em folheto mitral. Como não havia sinais sugestivos ou exames laboratoriais que corroborassem infecção bacteriana sistêmica, foi confirmado o diagnóstico de endocardite trombótica não bacteriana. Diante do mau prognóstico relacionado à doença, a suspeição e o tratamento precoce foram fatores determinantes para a evolução favorável apresentada.



Publication History

Received: 29 January 2023

Accepted: 21 May 2023

Article published online:
06 July 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Nicoli Taiana Henn, Mariana Burlamaque Cocio Martins, Renata Bruna Garcia dos Santos Gatelli. Non-bacterial thrombotic endocarditis: a case report with favorable evolution and literature review. Brazilian Journal of Oncology 2023; 19: e-20230406.
DOI: 10.5935/2526-8732.20230406
 
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