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DOI: 10.5935/2526-8732.20230415
Small cell neuroendocrine carcinoma of the breast - case series of a common tumour at a rare location
Carcinoma neuroendócrine de pequenas células da mama - série de casos de tumor comum em localização rara Financial support: None to declare.
ABSTRACT
Small cell neuroendocrine carcinoma of the breast is an uncommon primary tumor of the breast with literature limited to case reports and case series. We hereby report 3 cases of small cell neuroendocrine carcinoma of the breast who presented to our institute. One was an elderly lady and the other two were young females. Two of them were of luminal subtype whereas the third was of basal type. One of them occurred in a recurrent setting. The histopathology and immunohistochemistry of all tumors were consistent with neuroendocrine origin. All of them were treated with a combination of chemotherapy, surgery, and radiotherapy. It is important for prognostication as most of them present with a higher grade and stage. Treatment protocols need to be standardized for this rare and aggressive breast tumor.
RESUMO
O carcinoma neuroendócrino de pequenas células da mama é um tumor primário incomum da mama, com literatura limitada a relatos de casos e séries de casos. Relatamos 3 casos de carcinoma neuroendócrino de pequenas células da mama que se apresentaram em nosso instituto. Uma era uma senhora idosa e as outras duas eram mulheres jovens. Dois deles eram do subtipo luminal enquanto o terceiro era do tipo basal. Um deles ocorreu em um cenário recorrente. A histopatologia e a imuno-histoquímica de todos os tumores foram compatíveis com origem neuroendócrina. Todos eles foram tratados com uma combinação de quimioterapia, cirurgia e radioterapia. É importante para o prognóstico, pois a maioria deles apresenta grau e estágio mais elevados. Os protocolos de tratamento precisam ser padronizados para esse raro e agressivo tumor mamário.
Publication History
Received: 09 April 2023
Accepted: 18 June 2023
Article published online:
31 July 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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Dilip Harindran Vallathol, Thomas Babu, Sreedharan PS, Sajna VM Kutty, Thanseer NTK, Narayanankutty Warrier. Small cell neuroendocrine carcinoma of the breast - case series of a common tumour at a rare location. Brazilian Journal of Oncology 2023; 19: e-20230415.
DOI: 10.5935/2526-8732.20230415
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