Subscribe to RSS
DOI: 10.5935/2526-8732.20230433
A 50-year-old male with oropharyngeal squamous cell carcinoma metastatic to hand soft tissue and bone - a case report
Homem de 50 anos com carcinoma espinocelular de orofaringe metastático em tecidos moles e ossos da mão - relato de caso none to declareABSTRACT
A 50-year-old patient was referred to our service for the investigation of oropharynx cancer and was diagnosed with squamous cell carcinoma. Although there were no signs of distant metastasis, the disease was given as unresectable. The patient was treated with induction chemotherapy followed by chemoradiotherapy. After a trauma episode, the patient had pain in the right hand, being investigated with magnetic resonance, which demonstrated lesion of soft parts and bone structures. Additionally, in staging examinations, pulmonary metastasis was observed. Of the patients with oropharynx squamous carcinoma, approximately 15 to 20% develop metastases throughout the course of the disease, and metastases in soft parts are rare (less than 10% of those with known distance disease).
RESUMO
Paciente de 50 anos foi encaminhado ao nosso serviço para investigação de câncer de orofaringe e foi diagnosticado com carcinoma espinocelular. Embora não houvesse sinais de metástase à distância, a doença foi considerada irressecável. O paciente foi tratado com quimioterapia de indução seguida de quimiorradioterapia. Após episódio de trauma, o paciente apresentou dor em mão direita, sendo investigada com ressonância magnética, que demonstrou lesão de partes moles e estruturas ósseas. Além disso, nos exames de estadiamento foi observada metástase pulmonar. Dos pacientes com carcinoma escamoso de orofaringe, aproximadamente 15 a 20% desenvolvem metástases ao longo do curso da doença, e metástases em partes moles são raras (menos de 10% daqueles com doença à distância conhecida).
Publication History
Received: 19 July 2023
Accepted: 06 September 2023
Article published online:
19 October 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil
Rivadávio Antunes Menacho de Oliveira, Mariana Suemy Kiara, Eni Medeiros, Pamela Passarelli, Jean Gabriel Vieira Coutinho, Rafael Ricci Ferrari Manéa. A 50-year-old male with oropharyngeal squamous cell carcinoma metastatic to hand soft tissue and bone - a case report. Brazilian Journal of Oncology 2023; 19: e-20230433.
DOI: 10.5935/2526-8732.20230433
-
REFERENCES
- 1 Goodwin WJ. Distant metastases from oropharyngeal cancer. J Otorhinolaryngol Relat Spec 2001; Jul/Aug 63 (04) 222-3
- 2 World Health Organization (WHO), International Agency for Research on Cancer (IARC). Globocan 2020, Oropharynx [Internet]. Geneva: WHO/IARC; 2020. [access in 2023 Jun 17]. Available from https://gco.iarc.fr/today/data/factsheets/cancers/3-Oropharynx-fact-sheet.pdf
- 3 Ministério da Saúde (BR), Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). Estimativa 2023: incidência de câncer no Brasil [Internet]. Rio de Janeiro: Ministério da Saúde/INCA; 2023. [access: 2023, June, 12th]. Available from https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2023.pdf
- 4 Ministério da Saúde (BR), Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). Estimativa 2022: incidência de câncer no Brasil. Rio de Janeiro: Ministério da Saúde/INCA; 2022
- 5 Kowalski LP, Carvalho AL, Martins Priante AV, Magrin J. Predictive factors for distant metastasis from oral and oropharyngeal squamous cell carcinoma. Oral Oncol 2005; May 41 (05) 534-41
- 6 Parsons JT, Mendenhall WM, Stringer SP, Amdur RJ, Hinerman RW, Villaret DB. et al. Squamous cell carcinoma of the oropharynx: Surgery, radiation therapy, or both. Cancer 2002; Jun 94 (11) 2967-80
- 7 Jesse RH, Sugarbaker EV. Squamous cell carcinoma of the oropharynx: why we fail. Am J Surg 1976; Oct 132 (04) 435-8
- 8 Troell RJ, Terris DJ. Detection of metastases from head and neck cancers. Laryngoscope 1995; Mar 105 3 Pt 1 247-50
- 9 Marioni G, Blandamura S, Calgaro N, Ferraro SM, Stramare R, Staffieri A. et al. Distant muscular (gluteus maximus muscle) metastasis from laryngeal squamous cell carcinoma. Acta Otolaryngol 2005; Jun 125 (06) 678-82
- 10 Smeets R, Grosjean MB, Heiland M, Riediger D, Maciejewski O. Distant metastases of a squamous cell carcinoma of the tongue in peripheral skeletal muscles and adjacent soft tissues. Head Face Med 2008; Mar 4: 7
- 11 Merino OR, Lindberg RD, Fletcher GH. An analysis of distant metastasis from squamous cell carcinoma of upper respiratory and digestive tracts. Cancer 1977; Jul 40 (01) 145-51
- 12 Marcos CA, Pendás JL, Gutiérrez VF, Hermsen M, Albalad MPC, Espina HF. et al. Distant metastases in head and neck cancer. Acta Otorhininolaringol Esp 2006; Oct 57 (08) 369-72
- 13 Samuelian JM, Fisher BJ, Daugherty LC, Babaria UA. Oropharyngeal squamous cell carcinoma metastatic to lower-extremity soft tissues: a case report and literature review. Ear Nose Throat J 2013; Jun 92 (06) E38-E41
- 14 Liu JC, Bhayani M, Kuchta K, Galloway T, Fundkowski C. Patterns of distant metastasis in head and neck cancer at presentation: implications for initial evaluation. Oral Oncol 2019; Jan 88: 131-6
- 15 Sinha P, Lewis Junior JS, Kallogjeri D, Nussenbaum B, Haughey BH. Soft tissue metastasis in p16-positive oropharynx carcinoma: prevalence and association with distant metastasis. Oral Oncol 2015; Aug 51 (08) 778-86
- 16 Greco T, Cianni L, Mauro D, Dughiero G, Bocchi MB, Cazzato G. et al. Foot metastasis: current knowledge. Orthop Rev (Pavia) 2020; Jun 12 Suppl 1 8671