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CC BY 4.0 · Brazilian Journal of Oncology 2024; 20: e-20240447
DOI: 10.5935/2526-8732.20240447
Case Report
Surgical Oncology

Medullary colon carcinoma with microsatellite instability: case report

Carcinoma medular do cólon com instabilidade de microssatélites: relato de caso
Mayra Wilma Martins Cardoso Soares 
1   Instituto Doutor José Frota, General Surgery Center, Fortaleza - Ceará, Brazil
,
José Walter Feitosa Gomes 
1   Instituto Doutor José Frota, General Surgery Center, Fortaleza - Ceará, Brazil
,
Elam Vasconcelos de Aquino 
1   Instituto Doutor José Frota, General Surgery Center, Fortaleza - Ceará, Brazil
,
Igor Santos Costa 
2   Argos, Pathology Laboratory, Fortaleza - Ceará, Brazil
,
Gabriel Sampaio Feitosa 
3   Federal University of Ceará, Faculty of Medicine, Fortaleza - Ceará, Brazil
,
Mariana Macambira Noronha 
3   Federal University of Ceará, Faculty of Medicine, Fortaleza - Ceará, Brazil
,
Leonardo Saraiva Pontes 
4   Walter Cantídio University Hospital, Clinical Oncology Service, Fortaleza - Ceará, Brazil
› Author Affiliations Financial support: None to declare.
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ABSTRACT

Colorectal cancer is the third most common neoplasm and the second most lethal worldwide. The most common histological type is adenocarcinoma, characterized by its glandular pattern. Medullary colon carcinoma is a rare histological variant of colorectal cancer, characterized by a predominantly solid architecture, poorly differentiated or undifferentiated morphology, often associated with an anomalous immunophenotype and microsatellite instability. The present study reports a case in an academic service of general surgery of a 74-year-old patient who presented with a tumor of the ascending colon, histologically with an exuberant lymphocytic infiltrate, suggestive of large cell lymphoma, but which was revealed by subsequent immunohistochemistry to be medullary carcinoma of the colon with microsatellite instability.

RESUMO

O câncer colorretal é a terceira neoplasia mais comum e a segunda mais letal no mundo. O adenocarcinoma é o tipo histológico mais comum, caracterizado pelo seu padrão glandular. O carcinoma medular do cólon é uma variante histológica rara do câncer colorretal, caracterizada por uma arquitetura predominantemente sólida, morfologia pouco diferenciada ou indiferenciada, frequentemente associada a um imunofenótipo anômalo e instabilidade de microssatélites. O presente estudo relata um caso em um serviço acadêmico de cirurgia geral de um paciente de 74 anos que apresentou tumor de cólon ascendente, histologicamente com infiltrado linfocitário exuberante, sugestivo de linfoma de grandes células, mas que foi revelado através de exame subsequente imunohistoquímico como carcinoma medular do cólon com instabilidade de microssatélites.

Keywords:

Colonic neoplasms - Microsatellite instability - Carcinoma, Medullary

Palavras-chave:

Neoplasias colônicas - Instabilidade de microssatélites - Carcinoma medular


Publication History

Received: 13 October 2023

Accepted: 04 January 2024

Article published online:
07 February 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Mayra Wilma Martins Cardoso Soares, José Walter Feitosa Gomes, Elam Vasconcelos de Aquino, Igor Santos Costa, Gabriel Sampaio Feitosa, Mariana Macambira Noronha, Leonardo Saraiva Pontes. Medullary colon carcinoma with microsatellite instability: case report. Brazilian Journal of Oncology 2024; 20: e-20240447.
DOI: 10.5935/2526-8732.20240447
 

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