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DOI: 10.5935/2526-8732.20240447
Medullary colon carcinoma with microsatellite instability: case report
Carcinoma medular do cólon com instabilidade de microssatélites: relato de caso Financial support: None to declare.
ABSTRACT
Colorectal cancer is the third most common neoplasm and the second most lethal worldwide. The most common histological type is adenocarcinoma, characterized by its glandular pattern. Medullary colon carcinoma is a rare histological variant of colorectal cancer, characterized by a predominantly solid architecture, poorly differentiated or undifferentiated morphology, often associated with an anomalous immunophenotype and microsatellite instability. The present study reports a case in an academic service of general surgery of a 74-year-old patient who presented with a tumor of the ascending colon, histologically with an exuberant lymphocytic infiltrate, suggestive of large cell lymphoma, but which was revealed by subsequent immunohistochemistry to be medullary carcinoma of the colon with microsatellite instability.
RESUMO
O câncer colorretal é a terceira neoplasia mais comum e a segunda mais letal no mundo. O adenocarcinoma é o tipo histológico mais comum, caracterizado pelo seu padrão glandular. O carcinoma medular do cólon é uma variante histológica rara do câncer colorretal, caracterizada por uma arquitetura predominantemente sólida, morfologia pouco diferenciada ou indiferenciada, frequentemente associada a um imunofenótipo anômalo e instabilidade de microssatélites. O presente estudo relata um caso em um serviço acadêmico de cirurgia geral de um paciente de 74 anos que apresentou tumor de cólon ascendente, histologicamente com infiltrado linfocitário exuberante, sugestivo de linfoma de grandes células, mas que foi revelado através de exame subsequente imunohistoquímico como carcinoma medular do cólon com instabilidade de microssatélites.
Publikationsverlauf
Eingereicht: 13. Oktober 2023
Angenommen: 04. Januar 2024
Artikel online veröffentlicht:
07. Februar 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
Thieme Revinter Publicações Ltda.
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Mayra Wilma Martins Cardoso Soares, José Walter Feitosa Gomes, Elam Vasconcelos de Aquino, Igor Santos Costa, Gabriel Sampaio Feitosa, Mariana Macambira Noronha, Leonardo Saraiva Pontes. Medullary colon carcinoma with microsatellite instability: case report. Brazilian Journal of Oncology 2024; 20: e-20240447.
DOI: 10.5935/2526-8732.20240447
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