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CC BY-NC 4.0 · Arch Plast Surg 2013; 40(05): 627-629
DOI: 10.5999/aps.2013.40.5.627
Case Report

Experience of ReCell in Skin Cancer Reconstruction

Onur Gilleard
Department of Plastic Surgery, St Thomas Hospital, London, UK
,
Nicholas Segaren
Department of Plastic Surgery, St Thomas Hospital, London, UK
,
Ciaran Healy
Department of Plastic Surgery, St Thomas Hospital, London, UK
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The ReCell system (Avita Medical) is a cell culture product that allows the immediate processing of a small split-thickness skin biopsy to produce a complete population of cells including keratinocytes, melanocytes, Langerhans cells and fibroblasts. This series is the first to highlight the reconstructive applications of ReCell following ablative skin cancer surgery. The ReCell system was utilized for three patients following skin cancer excision. In two cases, the cells were applied to forehead flap donor sites following nasal reconstruction. In one case, the cells were applied to the calvarial periosteum following wide local excision of a melanoma scar. Assessment of the treated area was performed using the patient and observer scar assessment scale after 1 year. The Patient and Observer Scar Assessment Scale (POSAS) scores for the 2 patients treated with ReCell following forehead flap surgery were 22 and 32. The score for the patient that underwent wide local excision of a melanoma scar was 45. The absence of a donor site, accelerated healing and the satisfactory aesthetic appearance of the mature scars in this series suggest that ReCell may play a useful role in reconstruction following skin cancer excision.

Keywords

Guided tissue regeneration - Wound closure techniques - Skin


Publication History

Received: 20 March 2013

Accepted: 24 May 2013

Article published online:
01 May 2022

© 2013. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)

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  • References

  • 1 Gravante G, Di Fede MC, Araco A. et al. A randomized trial comparing ReCell system of epidermal cells delivery versus classic skin grafts for the treatment of deep partial thickness burns. Burns 2007; 33: 966-972
    CrossrefPubMedGoogle Scholar
  • 2 Draaijers LJ, Tempelman FR, Botman YA. et al. The patient and observer scar assessment scale: a reliable and feasible tool for scar evaluation. Plast Reconstr Surg 2004; 113: 1960-1965
    CrossrefPubMedGoogle Scholar
  • 3 Chester DL, Balderson DS, Papini RP. A review of keratinocyte delivery to the wound bed. J Burn Care Rehabil 2004; 25: 266-275
    CrossrefPubMedGoogle Scholar
  • 4 Green H, Kehinde O, Thomas J. Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci U S A 1979; 76: 5665-5668
    CrossrefPubMedGoogle Scholar
  • 5 Menick FJ. A 10-year experience in nasal reconstruction with the three-stage forehead flap. Plast Reconstr Surg 2002; 109: 1839-1855
    CrossrefPubMedGoogle Scholar