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CC BY-NC 4.0 · Arch Plast Surg 2014; 41(05): 452-457
DOI: 10.5999/aps.2014.41.5.452
Review Article

Proliferation of Keratinocytes Induced by Adipose-Derived Stem Cells on a Chitosan Scaffold and Its Role in Wound Healing, a Review

Sankaralakshmi Gomathysankar
Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
,
Ahmad Sukari Halim
Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
,
Nik Soriani Yaacob
Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
› Author AffiliationsSupported by: Universiti Sains Malaysia 1001/PPSP/813058
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In the field of tissue engineering and reconstruction, the development of efficient biomaterial is in high demand to achieve uncomplicated wound healing. Chronic wounds and excessive scarring are the major complications of tissue repair and, as this inadequate healing continues to increase, novel therapies and treatments for dysfunctional skin repair and reconstruction are important. This paper reviews the various aspects of the complications related to wound healing and focuses on chitosan because of its unique function in accelerating wound healing. The proliferation of keratinocytes is essential for wound closure, and adipose-derived stem cells play a significant role in wound healing. Thus, chitosan in combination with keratinocytes and adipose-derived stem cells may act as a vehicle for delivering cells, which would increase the proliferation of keratinocytes and help complete recovery from injuries.

Keywords

Chitosan - Keratinocytes - Stem cells - Wound healing

The work related to this paper was supported by a Research University Grant (1001/PPSP/813058) from Universiti Sains Malaysia.




Publication History

Received: 20 March 2014

Accepted: 26 April 2014

Article published online:
05 May 2022

© 2014. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)

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