CC BY-NC 4.0 · Arch Plast Surg 2018; 45(01): 14-22
DOI: 10.5999/aps.2017.01347
Original Article

Correlation between the time elapsed after liposuction and the risk of fat embolism: An animal model

Kwang-Ryeol Lim
Department of Plastic and Reconstructive Surgery, Dong-A University School of Medicine, Busan, Korea
,
Jeong-Min Cho
Department of Plastic and Reconstructive Surgery, Dong-A University School of Medicine, Busan, Korea
,
Chung-Min Yoon
Department of Plastic and Reconstructive Surgery, Dong-A University School of Medicine, Busan, Korea
,
Keun-Cheol Lee
Department of Plastic and Reconstructive Surgery, Dong-A University School of Medicine, Busan, Korea
,
Sang-Yun Lee
Ellium Women’s Hospital, Busan, Korea
,
Mi-Ha Ju
Department of Pathology, Dong-A University School of Medicine, Busan, Korea
› Author Affiliations

Background Liposuction has become one of the most frequently performed procedures in the field of aesthetic surgery. Fat embolism syndrome after liposuction can easily be overlooked or underestimated; however, occasionally, fulminating fat embolism syndrome can develop and lead to a critical situation within 2–3 days after lipoplasty. Changes over time in the amount of circulating fat particles and the histology of major organs have not yet been studied.

Methods This study was conducted using 18 male Sprague-Dawley rats aged 12 weeks and weighing 500–628 g (average, 562 g). Fifteen rats were used as the experimental group and 3 as the control group. Under general anesthesia, tumescent-technique liposuction was performed at the lateral flank areas and abdomen for 1 hour. Blood, lung, and brain tissue specimens were obtained at 1 hour, 1 day, and 2 days after the liposuction procedure.

Results The average number of fat particles in the blood samples was 25,960/dL at 1 hour, 111,100/dL at 24 hours, and 21,780/dL at 48 hours. The differences between study groups were statistically significant. Both intravascular and extravascular fat particles with inflammation were seen in all 15 rats, as were inflammatory cell infiltration, hemorrhage, and consolidation with shrinkage of the lung alveoli.

Conclusions These results imply that there is a strong possibility of fat embolism syndrome after liposuction in real clinical practice, and the first 24–48 hours after the operation were found to be the most important period for preventing pulmonary embolism and progression to fulminating fat embolism syndrome.

This study was supported by research funds from Dong-A University.




Publication History

Received: 17 August 2017

Accepted: 18 October 2017

Article published online:
03 April 2022

© 2018. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)

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