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CC BY-NC 4.0 · Arch Plast Surg 2017; 44(02): 95-100
DOI: 10.5999/aps.2017.44.2.95
Original Article

Vessel Remodeling after Intima-to-Intima Contact Anastomosis

Authors

  • Hyeonjung Yeo

    Department of Plastic and Reconstructive Surgery, Daegu Fatima Hospital, Daegu, Korea

  • Hyodong Kim

    Department of Plastic and Reconstructive Surgery, Daegu Fatima Hospital, Daegu, Korea

  • Daegu Son

    Department of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu, Korea

  • Changbae Hong

    College of Physical Education, Keimyung University, Daegu, Korea

  • Sun Young Kwon

    Department of Pathology, Keimyung University School of Medicine, Daegu, Korea
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Background Intima-to-intima microanastomotic vascular remodeling was explored, utilizing a polylactide-caprolactone absorbable vein coupler model (PAVCM), which was designed to simulate a non-absorbable counterpart system with the sole exception of being absorbable.

Methods Six New Zealand white rabbits were used. After transection of the jugular vein, 2 PAVCMs were placed, 1 at each transected end. The stumps were slipped through the PAVCMs, and the venous wall was everted 90° to achieve intima-to-intima contact. Reanastomosis of the transected jugular vein was performed bilaterally in 3 rabbits. In the other 3 rabbits, the jugular vein (20 mm) harvested from one side was interpositionally grafted to the jugular vein on the opposite side to ease the anastomotic tension. Patency testing, ultrasonography, and histologic assessments were conducted postoperatively at weeks 2, 4, 12, 16, 22, and 26.

Results All anastomotic sites were patent, without stenosis, occlusion, or dilatation. In the histologic sections, immature endothelial regeneration was observed at week 2, which was completed by week 4. Regeneration of the tunica media was noted at week 12. Between week 22 and week 26, the tunica media fully regenerated and the coupler dissipated entirely.

Conclusions Despite the absence of a coupler to act as an anastomotic buttress, the structure and function of all the vessels appeared normal, even histologically. These outcomes are true milestones in the development of an absorbable vein coupler.

Anastomosis, surgical - Microsurgery - Vascular surgical procedures

This article was presented at the Second Research and Reconstructive Forum of the Korean Society of Plastic and Reconstructive Surgeons on June 1-2, 2012, in Gwangju, Korea.




Publication History

Received: 25 August 2016

Accepted: 02 January 2017

Article published online:
20 April 2022

© 2017. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)

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