Haloperidol-induced catalepsy in mice and rats suppressed by orally pre-administered potentized Agaricus

Abstract

Agaricus muscarius 30s, a potentized homoeopathic drug prepared by successive dilution and sonication from the alcoholic extract of the fungus of the same name, significantly reduced haloperidol-induced catalepsy in mice and rats. The drug produced the anticataleptic effect when administered orally and no such effect when administered intraperitoneally. Open field activity of the mice was suppressed more with haloperidol (hal) alone than with the combination of Agaricus 30s (oral) and hal. Agaricus 30s, given intraperitoneally, did not alter hal-induced suppression of the spontaneous activity of mice. Based on the previously reported results with Agaricus in combination with apomorphine, D1 and D2 agonists, it was thought that Agaricus might have served as a D1 blocker. It was further assumed that the effect of Agaricus was mediated through the oral taste receptors.

Keywords

Haloperidol - Catalepsy - Agaricus muscarius - Homoeopathic potency - Anticataleptic effect - Oral route - Ultrasound