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DOI: 10.1016/S2213-6320(17)30032-5
Multiple Choice Question – Pharmacotherapy of Epilepsy
Publication History
Publication Date:
06 May 2018 (online)
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Q.1 Which of the following Anti-Epileptic Drugs (AEDs) should be avoided in an ICU patient who is on meropenem for pneumonia?
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A) Sodium Valproate
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B) Levetiracetam
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C) Lacosamide
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D) Midazolam
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Q.2 All of the following AEDs except one are consider to be enzyme-inducing AEDs
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A) Phenytoin
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B) Carbamazepine
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C) Primidone
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D) Sodium Valproate
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Q.3 The proposed mechanism of action for Levetiracetam is:
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A) Modifies synaptic release of glutamate and GABA through action on vesicular function
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B) Enhances slow inactivation of voltage-gated Sodium Channels
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C) Inhibits Carbonic Anhydrase
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D) Irreversibly inhibits GABA aminotransferase
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Q.4 Rufinamide is indicated for
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A) Adjunctive treatment of focal epilepsy
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B) Adjunctive treatment of the Lennox-Gastaut Syndrome
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C) Generalized tonic-clonic seizures
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D) Status Epilepticus
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Q.5 Which of the following side-effects can be attributed to Topiramate?
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A) Nephrolithiasis
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B) Gingival hyperplasia
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C) Hemorrhagic Pancreatitis
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D) Weight gain
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Q.6 Fatal cases of aplastic anemia have been reported with use of the following AEDs:
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A) Levetiracetam and Pregablin
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B) Carbamazepine and Felbamate
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C) Lacosamide and tiagabine
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D) Phenytoin and phenobarbital
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Q.7 Ethosuximide is indicated for treatment of:
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A) Focal epilepsy
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B) Generalized tonic-clonic seizures
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C) Generalized non-motor (absence) seizures
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D) Unclassified epilepsy
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Q.8 Idiosyncratic reactions of Valproate include all of the following except
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A) Hepatotoxicity
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B) Pancreatitis
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C) Thrombocytopenia
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D) Psychosis
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Q.9 Chronic dose-related adverse effects of valproate include all of the following except
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A) Weight gain
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B) Hair loss
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C) Peripheral neuropathy
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D) Endocrine and metabolic changes
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Q.10 Vigabitrin is indicated for myoclonic epilepsy
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A) True
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B) False
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Answer Keys-
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A
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D
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A
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B
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A
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B
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C
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D
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C
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B
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No conflict of interest has been declared by the author(s).