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DOI: 10.1055/a-0630-0232
Pleiotropic Effect of Lipoprotein-Apheresis on the Soluble Form of Activated Leukocyte Cell Adhesion Molecule (sALCAM) in Familial Hypercholesterolaemia
Publication History
received 31 August 2017
revised 06 April 2018
accepted 27 April 2018
Publication Date:
11 June 2018 (online)
![](https://www.thieme-connect.de/media/eced/201905/lookinside/thumbnails/08-2017-0339-endo_10-1055-a-0630-0232-1.jpg)
Abstract
Introduction/Background Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a pattern recognition receptor (PRR), while its soluble form sALCAM is involved in ALCAM-dependent and -independent immune mechanisms. The aim of this study was to investigate the effect of aggressive removal of low density lipoprotein-cholesterol (LDL-C) and lipoprotein(a) (Lp [a]) by lipoprotein-apheresis (LA) on sALCAM and blood viscosity as well as to evaluate its association with lipoproteins and serum markers of inflammation.
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