Pharmacological Control of Complications Following to Third Molar Removal: Evidence Based on A Meta-Analysis

Mario Alberto Isiordia-Espinoza; Ronell Eduardo Bologna-Molina; Ycenna Ailed Hernández-Miramontes; Juan Ramón Zapata-Morales; Angel Jobsabad Alonso-Castro; Flavio Martínez-Morales; Sergio Sánchez-Enriquez; Nicolás Addiel Serafín-Higuera; Guillermo Pérez-Cortez; Lorenzo Franco-de la Torre

doi:10.1055/a-0637-8948

Drug Research, Table of Contents

Drug Res (Stuttg) 2019; 69(01): 5-11
DOI: 10.1055/a-0637-8948

Review

Pharmacological Control of Complications Following to Third Molar Removal: Evidence Based on A Meta-Analysis

Mario Alberto Isiordia-Espinoza

¹Departamento de Clínicas, División de Ciencias Biomédicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México

²Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, SLP, México

,

Ronell Eduardo Bologna-Molina

³Departamento de Investigación, Facultad de Odontología, Universidad de la República (UDELAR), Montevideo, Uruguay

,

Ycenna Ailed Hernández-Miramontes

⁴Consultorio particular, Tepic, Nayarit

,

Juan Ramón Zapata-Morales

⁵Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, México

,

Angel Jobsabad Alonso-Castro

⁵Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, México

,

Flavio Martínez-Morales

²Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, SLP, México

,

Sergio Sánchez-Enriquez

¹Departamento de Clínicas, División de Ciencias Biomédicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México

,

Nicolás Addiel Serafín-Higuera

⁶Facultad de Odontología, Universidad Autónoma de Baja California, Mexicali, Baja California, México

,

Guillermo Pérez-Cortez

⁶Facultad de Odontología, Universidad Autónoma de Baja California, Mexicali, Baja California, México

,

Lorenzo Franco-de la Torre

¹Departamento de Clínicas, División de Ciencias Biomédicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México

› Author Affiliations

Abstract

Aims The purpose of this meta-analysis was to evaluate the clinical efficacy of non-steroidal anti-inflammatory drugs and dexamethasone on the trismus, postsurgical pain, facial swelling, as well as the analgesic consumption after third molar surgery.

Material and Methods The reports were identified in the most important medical databases. Those studies that met the requirements were fully assessed according to the inclusion and exclusion criteria. The quality of each report was evaluated with the Oxford Quality Scale and using the Cochrane Collaboration’s risk of bias tool. Each meta-analysis was done using the technique of mean difference and 95% confidence intervals employing a random effects model with the Review Manager 5.3., from the Cochrane Library. Significant statistical difference was accepted when the p value was less than 0.05 on the test of overall effect (Z value).

Results Qualitative evaluation was done using the data of 330 patients extracted from seven articles and the quantitative assessment with data of 200 patients from three reports. It was not observed difference among non-steroidal anti-inflammatory drugs and dexamethasone in any of the clinical effectiveness indicators.

Conclusion The outcomes of our meta-analysis indicate that non-steroidal anti-inflammatory drugs and dexamethasone have good therapeutic effect for the management of inflammatory complications following to third molar surgery.

Key words

Non-steroidal Anti-inflammatory Drugs - Dexamethasone - Post-surgical Complications - Third Molar Surgery - Evidence-Based Dentistry

Full Text

References

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