Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus

Ivy B. Ramis; Júlia S. Vianna; Ana Júlia Reis; Andrea von Groll; Daniela F. Ramos; Miguel Viveiros; Pedro E. Almeida da Silva

doi:10.1055/a-0639-5412

Planta Medica, Inhaltsverzeichnis

Planta Med 2018; 84(17): 1265-1270
DOI: 10.1055/a-0639-5412

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus

Ivy B. Ramis

¹Núcleo de Pesquisa em Microbiologia Médica, Universidade Federal de Rio Grande, Rio Grande, RS, Brazil

,

Júlia S. Vianna

¹Núcleo de Pesquisa em Microbiologia Médica, Universidade Federal de Rio Grande, Rio Grande, RS, Brazil

,

Ana Júlia Reis

¹Núcleo de Pesquisa em Microbiologia Médica, Universidade Federal de Rio Grande, Rio Grande, RS, Brazil

,

Andrea von Groll

¹Núcleo de Pesquisa em Microbiologia Médica, Universidade Federal de Rio Grande, Rio Grande, RS, Brazil

,

Daniela F. Ramos

¹Núcleo de Pesquisa em Microbiologia Médica, Universidade Federal de Rio Grande, Rio Grande, RS, Brazil

,

Miguel Viveiros

²Unidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisboa, Portugal

,

Pedro E. Almeida da Silva

¹Núcleo de Pesquisa em Microbiologia Médica, Universidade Federal de Rio Grande, Rio Grande, RS, Brazil

› Institutsangaben

Abstract

New drugs are needed to treat infections with antimicrobial-resistant Mycobacterium abscessus; therefore, we evaluated usnic acid as an antimicrobial agent and efflux inhibitor (EI) against M. abscessus. Usnic acid showed antimicrobial activity, and synergistically, the EI verapamil increased this activity. In addition, when we evaluated the interaction of antimicrobials with usnic acid, the increase of their activity was observed. Finally, usnic acid showed an efflux inhibitory effect between the classical EIs verapamil and carbonyl cyanide m-chlorophenylhydrazine. In conclusion, usnic acid showed both antimicrobial and EI activity, indicating that this natural compound may be a promising scaffold for new drugs against this difficult-to-treat microorganism.

Key words

usnic acid - verapamil - Mycobacterium abscessus - efflux inhibitor - antimicrobial

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Referenzen

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