Subscribe to RSS
DOI: 10.1055/a-0770-6093
8-Week Basic Military Training Improves Adiponectin Multimer Ratio in Healthy Young Males
Publication History
accepted 13 October 2018
Publication Date:
27 November 2018 (online)
Abstract
To investigate the effect of exercise on adiponectin in young healthy human males, we examined serum total adiponectin and high-molecular-weight (HMW) adiponectin in newly recruited male soldiers who participated in an 8-week basic military training (BMT). A total of 95 males (mean age, 18.79±1.50 years) were sampled from among 1,100 new male army recruits in China. Participants were separated into 3 groups according to their body mass index (BMI): overweight group (BMI: 24.9 kg/m2 to<30 kg/m2; n=26); normal-weight group (BMI: 18.5 kg/m2 to<24.9 kg/m2; n=40); and underweight group (BMI:<18.5 kg/m2; n=29). Anthropometric measurements, fasting serum total adiponectin, HMW adiponectin, and lipid profiles were recorded at baseline and at the end of the 8-week BMT. After the 8-week BMT, the HMW/total adiponectin ratio (HMW/total ratio) and HDL cholesterol improved significantly (p<0.001 and p<0.001, respectively). HMW/total ratio showed significant correlations with HDL cholesterol. Our study suggests that an 8-week BMT can improve the HMW/total ratio in healthy young males regardless of their BMI and anthropometry. Both HMW/total ratio and HDL cholesterol can serve as potential biomarkers for assessing the efficacy of exercise and may have metabolic benefits for preventing obesity and obesity-related disease.
-
References
- 1 Abbenhardt C, McTiernan A, Alfano CM, Wener MH, Campbell KL, Duggan C, Foster-Schubert KE, Kong A, Toriola AT, Potter JD, Mason C, Xiao L, Blackburn GL, Bain C, Ulrich CM. Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels. J Intern Med 2013; 274: 163-175
- 2 Aso Y, Yamamoto R, Wakabayashi S, Uchida T, Takayanagi K, Takebayashi K, Okuno T, Inoue T, Node K, Tobe T, Inukai T, Nakano Y. Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin. Diabetes 2006; 55: 1954-1960
- 3 Bobbert T, Rochlitz H, Wegewitz U, Akpulat S, Mai K, Weickert MO, Mohlig M, Pfeiffer AF, Spranger J. Changes of adiponectin oligomer composition by moderate weight reduction. Diabetes 2005; 54: 2712-2719
- 4 Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982; 14: 377-381
- 5 Calton EK, Miller VS, Soares MJ. Factors determining the risk of the metabolic syndrome: Is there a central role for adiponectin?. Eur J Clin Nutr 2013; 67: 485-491
- 6 Cederberg H, Mikkola I, Jokelainen J, Laakso M, Harkonen P, Ikaheimo T, Laakso M, Keinanen-Kiukaanniemi S. Exercise during military training improves cardiovascular risk factors in young men. Atherosclerosis 2011; 216: 489-495
- 7 Christou GA, Kiortsis DN. Adiponectin and lipoprotein metabolism. Obes Rev 2013; 14: 939-949
- 8 Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knopp RH, Brunzell JD, Kahn SE. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex. Diabetologia 2003; 46: 459-469
- 9 Cooper KH. A means of assessing maximal oxygen intake. Correlation between field and treadmill testing. Jama 1968; 203: 201-204
- 10 Ebrahimi-Mamaeghani M, Mohammadi S, Arefhosseini SR, Fallah P, Bazi Z. Adiponectin as a potential biomarker of vascular disease. Vasc Health Risk Manag 2015; 11: 55-70
- 11 Emken BA, Richey J, Belcher B, Hsu YW, Spruijt-Metz D. Objectively measured physical activity is negatively associated with plasma adiponectin levels in minority female youth. Int J Pediatr Endocrinol 2010; 2010: 846070
- 12 Fasshauer M, Kralisch S, Klier M, Lossner U, Bluher M, Klein J, Paschke R. Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2003; 301: 1045-1050
- 13 Guo C, Guo J, Jin H, Yang C, Liu M, Jiang Y, Chen W, Zhang J. Promulgation of dietary allowances for military personnel GJB 823B-2016. J Prev Med Chin PLA 2017; 35: 79-81 (in Chinese)
- 14 Han X, Feng Y, Guo H, Feng G, Jiang J, Li C, Zhu J. Nuerlan. Effect of 8-week basic military training on new conscripts’ V02max in Xinjiang frontier armed police. J Prev Med Chin PLA 2015; 33: 503-505 (in Chinese)
- 15 Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T. Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 2006; 29: 1357-1362
- 16 Harriss DJ, Macsween A, Atkinson G. Standards for ethics in sport and exercise science research: 2018 update. Int J Sports Med 2017; 38: 1126-1131
- 17 Kim YS, Nam JS, Yeo DW, Kim KR, Suh SH, Ahn CW. The effects of aerobic exercise training on serum osteocalcin, adipocytokines and insulin resistance on obese young males. Clin Endocrinol (Oxf) 2015; 82: 686-694
- 18 Kizer JR, Benkeser D, Arnold AM, Djousse L, Zieman SJ, Mukamal KJ, Tracy RP, Mantzoros CS, Siscovick DS, Gottdiener JS, Ix JH. Total and high-molecular-weight adiponectin and risk of coronary heart disease and ischemic stroke in older adults. J Clin Endocrinol Metab 2013; 98: 255-263
- 19 Lara-Castro C, Fu Y, Chung BH, Garvey WT. Adiponectin and the metabolic syndrome: Mechanisms mediating risk for metabolic and cardiovascular disease. Curr Opin Lipidol 2007; 18: 263-270
- 20 Lara-Castro C, Luo N, Wallace P, Klein RL, Garvey WT. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes 2006; 55: 249-259
- 21 Li FY, Cheng KK, Lam KS, Vanhoutte PM, Xu A. Cross-talk between adipose tissue and vasculature: Role of adiponectin. Acta Physiol (Oxf) 2011; 203: 167-180
- 22 Lim HS, Tayebjee MH, Tan KT, Patel JV, Macfadyen RJ, Lip GY. Serum adiponectin in coronary heart disease: ethnic differences and relation to coronary artery disease severity. Heart 2005; 91: 1605-1606
- 23 Metcalf BS, Jeffery AN, Hosking J, Voss LD, Sattar N, Wilkin TJ. Objectively measured physical activity and its association with adiponectin and other novel metabolic markers: A longitudinal study in children (EarlyBird 38). Diabetes Care 2009; 32: 468-473
- 24 Mikkola I, Jokelainen JJ, Timonen MJ, Harkonen PK, Saastamoinen E, Laakso MA, Peitso AJ, Juuti AK, Keinanen-Kiukaanniemi SM, Makinen TM. Physical activity and body composition changes during military service. Med Sci Sports Exerc 2009; 41: 1735-1742
- 25 Miller KN, Burhans MS, Clark JP, Howell PR, Polewski MA, DeMuth TM, Eliceiri KW, Lindstrom MJ, Ntambi JM, Anderson RM. Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids. Aging Cell 2017; 16: 497-507
- 26 Mousavinasab F, Tahtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinanen-Kiukaanniemi S. Lack of increase of serum adiponectin concentrations with a moderate weight loss during six months on a high-caloric diet in military service among a young male Finnish population. Endocrine 2005; 26: 65-69
- 27 Myers J. Cardiology patient pages. Exercise and cardiovascular health. Circulation 2003; 107: e2-e5
- 28 Nedvidkova J, Smitka K, Kopsky V, Hainer V. Adiponectin, an adipocyte-derived protein. Physiol Res 2005; 54: 133-140
- 29 Neumeier M, Sigruener A, Eggenhofer E, Weigert J, Weiss TS, Schaeffler A, Schlitt HJ, Aslanidis C, Piso P, Langmann T, Schmitz G, Scholmerich J, Buechler C. High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes. Biochem Biophys Res Commun 2007; 352: 543-548
- 30 O'Leary VB, Jorett AE, Marchetti CM, Gonzalez F, Phillips SA, Ciaraldi TP, Kirwan JP. Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adults. Am J Physiol Endocrinol Metab 2007; 293: E421-E427
- 31 Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004; 279: 12152-12162
- 32 Pischon T, Hu FB, Girman CJ, Rifai N, Manson JE, Rexrode KM, Rimm EB. Plasma total and high molecular weight adiponectin levels and risk of coronary heart disease in women. Atherosclerosis 2011; 219: 322-329
- 33 Saito T, Murata M, Otani T, Tamemoto H, Kawakami M, Ishikawa SE. Association of subcutaneous and visceral fat mass with serum concentrations of adipokines in subjects with type 2 diabetes mellitus. Endocr J 2012; 59: 39-45
- 34 Shing CM, Webb JJ, Driller MW, Williams AD, Fell JW. Circulating adiponectin concentration and body composition are altered in response to high-intensity interval training. J Strength Cond Res 2013; 27: 2213-2218
- 35 Simpson KA, Singh MA. Effects of exercise on adiponectin: A systematic review. Obesity (Silver Spring) 2008; 16: 241-256
- 36 Thivel D, Metz L, Julien A, Morio B, Duche P. Obese but not lean adolescents spontaneously decrease energy intake after intensive exercise. Physiol Behav 2014; 123: 41-46
- 37 Tsao TS, Murrey HE, Hug C, Lee DH, Lodish HF. Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem 2002; 277: 29359-29362
- 38 Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, Bielicki JK, Mertens A, Quarck R, Benhabiles N, Marguerie G, Mackness B, Mackness M, Ninio E, Herregods MC, Balligand JL, Holvoet P. Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice. Circulation 2004; 110: 3259-3269
- 39 Vu V, Riddell MC, Sweeney G. Circulating adiponectin and adiponectin receptor expression in skeletal muscle: Effects of exercise. Diabetes Metab Res Rev 2007; 23: 600-611
- 40 Wang Y, Zheng A, Yan Y, Song F, Kong Q, Qin S, Zhang D. Association between HMW adiponectin, HMW-total adiponectin ratio and early-onset coronary artery disease in chinese population. Atherosclerosis 2014; 235: 392-397
- 41 Yu N, Ruan Y, Gao X, Sun J. Systematic review and meta-analysis of randomized, controlled trials on the effect of exercise on serum leptin and adiponectin in overweight and obese individuals. Horm Metab Res 2017; 49: 164-173
- 42 Zhu N, Pankow JS, Ballantyne CM, Couper D, Hoogeveen RC, Pereira M, Duncan BB, Schmidt MI. High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study. J Clin Endocrinol Metab 2010; 95: 5097-5104