Supervised Short-term High-intensity Training on Plasma Irisin Concentrations in Type 2 Diabetic Patients

Tobias Dünnwald; Andreas Melmer; Hannes Gatterer; Karin Salzmann; Christoph Ebenbichler; Martin Burtscher; Wolfgang Schobersberger; Wilhelm Grander

doi:10.1055/a-0828-8047

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2019; 40(03): 158-164
DOI: 10.1055/a-0828-8047

Physiology & Biochemistry

Supervised Short-term High-intensity Training on Plasma Irisin Concentrations in Type 2 Diabetic Patients

Tobias Dünnwald^*

¹Department of Psychology and Medical Sciences, Institute for Sports Medicine, Alpine Medicine & Health Tourism (ISAG), Hall, Austria

,

Andreas Melmer^*

²Universitätsklinik für Diabetologie, Endokrinologie, Inselspital, Universitätsspital Bern, Bern, Switzerland

,

Hannes Gatterer

³Institute of Mountain Emergency Medicine, EURAC Research, Bolzano, Italy

,

Karin Salzmann

⁴Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria

,

Christoph Ebenbichler

⁴Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria

,

Martin Burtscher

⁵Sport Science, University of Innsbruck, Innsbruck, Austria

,

Wolfgang Schobersberger

⁶Department of Psychology, Medical Sciences & Health Systems Management, University for Health Sciences, Medical Informatics and Technology, Hall in Tyrol, Austria

⁷Tirol Kliniken GmbH Innsbruck, Institute for Sports Medicine, Alpine Medicine & Health Tourism (ISAG), Innsbruck, Austria

,

Wilhelm Grander

⁸Department of Internal Medicine, Landeskrankenhaus Hall, Hall, Austria

› Institutsangaben

Abstract

Irisin is a myokine involved in adipocyte transformation. Its main beneficial effects arise from increased energy expenditure. Irisin production is particularly stimulated by physical exercise. The present study investigates the changes of plasma irisin in type 2 diabetic patients performing 2 different training modalities. Fourteen type 2 diabetic patients underwent 4 week of supervised high-intensity interval training (HIT; n=8) or continuous moderate-intensity training (CMT; n=6), with equivalent total amounts of work required. Plasma samples were collected in the resting state atbaseline and one day after the exercise intervention to analyse resting plasma irisin, blood lipids, blood glucose, hsCRP, Adiponectin, Leptin and TNF-α concentrations. In addition, body composition and VO_2peak were determined Resting plasma irisin increased after HIT (p=0.049) and correlated significantly with plasma fasting glucose at follow-up (r=0.763; p=0.006). CMT did not significantly change the amount of plasma irisin, although follow-up values of plasma irisin correlated negatively with fat-free mass (r=−0.827, p=0.002) and with fasting plasma glucose (r = − 0.934, p=0.006). Plasma irisin was found to increase with higher training intensity, confirming the assumption that exercise intensity, in addition to the type of exercise, may play an important role in the stimulation of the irisin response.

Key words

plasma irisin - high intensity exercise - type 2 diabetes mellitus

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