Cardiometabolic Response to a Single High-intensity Interval Exercise Session Versus Breaking up Sedentary Time with Fragmented High-intensity Interval Exercise

Abstract

This study compared the effects of interrupting prolonged sedentary time with high-intensity physical activity (SED-ACT), a volume- and duration-matched high-intensity interval exercise session followed by prolonged sedentary time (HIIE), and prolonged uninterrupted sedentary time (SED) on postprandial glucose, insulin and triglyceride concentrations. Twelve sedentary and inactive but otherwise healthy adults completed 3, 6.5 h conditions in an incomplete counterbalanced order. During SED, participants sat continuously. For HIIE, participants completed 10×60 s cycling bouts at 90% maximum oxygen update (V̇O_2max) with 1 min active recovery between bouts. In SED-ACT, 60 s cycling bouts at 90% V̇O_2max were completed every 30 min (10 times in total) with 30 s of active recovery immediately before and after. Standardised meals were consumed at 0 h and 3 h and capillary blood samples were collected fasted and every 30 min. Compared with SED, postprandial glucose incremental area under the curve (iAUC) was significantly lower in SED-ACT by 1.91 mmol/L∙6.5 h (p=0.022) and triglyceride iAUC was significantly lower in HIIE by 1.02 mmol/L∙6.5 h (p=0.030). Interrupting sedentary time with high-intensity physical activity can lower postprandial glucose concentrations, whereas a HIIE session can lower postprandial triglyceride concentrations.

Key words

sedentary behaviour - physical activity - postprandial metabolism - glucose - lipids - lipids - HIT

• References

• 1 Adams OP. The impact of brief high-intensity exercise on blood glucose levels. Diabetes Metab Syndr Obes 2013; 6: 113-122
• 2 Altenburg TM, Rotteveel J, Dunstan DW, Salmon J, Chinapaw MJ. The effect of interrupting prolonged sitting time with short, hourly, moderate-intensity cycling bouts on cardiometabolic risk factors in healthy, young adults. J Appl Physiol (1985) 2013; 115: 1751-1756
• 3 Bailey DP, Broom DR, Chrismas BC, Taylor L, Flynn E, Hough J. Breaking up prolonged sitting time with walking does not affect appetite or gut hormone concentrations but does induce an energy deficit and suppresses postprandial glycaemia in sedentary adults. Appl Physiol Nutr Metab 2016; 41: 324-331
• 4 Bailey DP, Locke CD. Breaking up prolonged sitting with light-intensity walking improves postprandial glycemia, but breaking up sitting with standing does not. J Sci Med Sport 2015; 18: 294-298
• 5 Bailey DP, Maylor BD, Orton CJ, Zakrzewski-Fruer JK. Effects of breaking up prolonged sitting following low and high glycaemic index breakfast consumption on glucose and insulin concentrations. Eur J Appl Physiol 2017; 117: 1299-1307
• 6 Bergouignan A, Latouche C, Heywood S, Grace MS, Reddy-Luthmoodoo M, Natoli AK, Owen N, Dunstan DW, Kingwell BA. Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials. Sci Rep 2016; 6: 32044
• 7 Bhammar DM, Sawyer BJ, Tucker WJ, Gaesser GA. Breaks in sitting time: Effects on continuously monitored glucose and blood pressure. Med Sci Sports Exerc 2017; 49: 2119-2130
• 8 Bhatnagar P, Wickramasinghe K, Williams J, Rayner M, Townsend N. The epidemiology of cardiovascular disease in the UK 2014. Heart 2015; 101: 1182-1189
• 9 Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle. Sports Med 2013; 43: 927-954
• 10 Champion RB, Smith LR, Smith J, Hirlav B, Maylor BD, White SL, Bailey DP. Reducing prolonged sedentary time using a treadmill desk acutely improves cardiometabolic risk markers in male and female adults. J Sports Sci 2018; 36: 2484-2491
• 11 Chu A, Boutcher YN, Boutcher SH. Effect of acute interval sprinting exercise on postprandial lipemia of sedentary young men. J Exerc Nutrition Biochem 2016; 20: 9-14
• 12 Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2^nd ed. Hillsdale, NJ: Erlbaum; 1988
• 13 Diabetes UK. Diabetes: Facts and Stats. 2015 https://www.diabetes.org.uk/Documents/Position %20statements/Diabetes %20UK %20Facts %20and %20Stats_Dec %202015.pdf Accessed 23 March 2016
• 14 Dunstan DW, Kingwell BA, Larsen R, Healy GN, Cerin E, Hamilton MT, Shaw JE, Bertovic DA, Zimmet PZ, Salmon J, Owen N. Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care 2012; 35: 976-983
• 15 Engeroff T, Fuzeki E, Vogt L, Banzer W. Breaking up sedentary time, physical activity and lipoprotein metabolism. J Sci Med Sport 2017; 20: 678-683
• 16 Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39: 175-191
• 17 Gillen JB, Little JP, Punthakee Z, Tarnopolsky MA, Riddell MC, Gibala MJ. Acute high-intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes. Diabetes Obes Metab 2012; 14: 575-577
• 18 Greiwe JS, Holloszy JO, Semenkovich CF. Exercise induces lipoprotein lipase and GLUT-4 protein in muscle independent of adrenergic-receptor signaling. J Appl Physiol (1985) 2000; 89: 176-181
• 19 Harriss DJ, Macsween A, Atkinson G. Standards for ethics in sport and exercise science research: 2018 update. Int J Sports Med 2017; 38: 1126-1131
• 20 Henson J, Davies MJ, Bodicoat DH, Edwardson CL, Gill JM, Stensel DJ, Tolfrey K, Dunstan DW, Khunti K, Yates T. Breaking up prolonged sitting with standing or walking attenuates the postprandial metabolic response in postmenopausal women: A randomized acute study. Diabetes Care 2016; 39: 130-138
• 21 Holloszy JO, Kohrt WM, Hansen PA. The regulation of carbohydrate and fat metabolism during and after exercise. Front Biosci 1998; 3: D1011-D1027
• 22 Latouche C, Jowett JB, Carey AL, Bertovic DA, Owen N, Dunstan DW, Kingwell BA. Effects of breaking up prolonged sitting on skeletal muscle gene expression. J Appl Physiol (1985) 2013; 114: 453-460
• 23 Lee CL, Kuo YH, Cheng CF. Acute high-intensity interval cycling improves postprandial lipid metabolism. Med Sci Sports Exerc 2018; 50: 1687-1696
• 24 Maylor BD, Zakrzewski-Fruer JK, Orton CJ, Bailey DP. Beneficial postprandial lipaemic effects of interrupting sedentary time with high-intensity physical activity versus a continuous moderate-intensity physical activity bout: A randomised crossover trial. J Sci Med Sport 2018; 21: 1250-1255
• 25 Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO. A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 1990; 51: 241-247
• 26 Miyashita M. Effects of continuous versus accumulated activity patterns on postprandial triacylglycerol concentrations in obese men. Int J Obes (Lond) 2008; 32: 1271-1278
• 27 Miyashita M, Edamoto K, Kidokoro T, Yanaoka T, Kashiwabara K, Takahashi M, Burns S. Interrupting sitting time with regular walks attenuates postprandial triglycerides. Int J Sports Med 2016; 37: 97-103
• 28 O'Keefe JH, Bell DS. Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol 2007; 100: 899-904
• 29 Ortega JF, Fernandez-Elias VE, Hamouti N, Pallares JG, Mora-Rodriguez R. Higher insulin-sensitizing response after sprint interval compared to continuous exercise. Int J Sports Med 2015; 36: 209-214
• 30 Peddie MC, Bone JL, Rehrer NJ, Skeaff CM, Gray AR, Perry TL. Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: A randomized crossover trial. Am J Clin Nutr 2013; 98: 358-366
• 31 Poole DC, Jones AM. Measurement of the maximum oxygen uptake V̇o2max: V̇o2peak is no longer acceptable. J Appl Physiol (1985) 2017; 122: 997-1002
• 32 Pulsford RM, Stamatakis E, Britton AR, Brunner EJ, Hillsdon M. Associations of sitting behaviours with all-cause mortality over a 16-year follow-up: The Whitehall II study. Int J Epidemiol 2015; 44: 1909-1916
• 33 Saunders TJ, Atkinson HF, Burr J, MacEwen B, Skeaff CM, Peddie MC. The acute metabolic and vascular impact of interrupting prolonged sitting: A systematic review and meta-analysis. Sports Med 2018; 48: 2347-2366
• 34 Tan M, Chan Moy Fat R, Boutcher YN, Boutcher SH. Effect of high-intensity intermittent exercise on postprandial plasma triacylglycerol in sedentary young women. Int J Sport Nutr Exerc Metab 2014; 24: 110-118
• 35 Valdes CT, Elkind-Hirsch KE. Intravenous glucose tolerance test-derived insulin sensitivity changes during the menstrual cycle. J Clin Endocrinol Metab 1991; 72: 642-646
• 36 Wilmot EG, Edwardson CL, Achana FA, Davies MJ, Gorely T, Gray LJ, Khunti K, Yates T, Biddle SJ. Sedentary time in adults and the association with diabetes, cardiovascular disease and death: Systematic review and meta-analysis. Diabetologia 2012; 55: 2895-2905
• 37 Yang TJ, Wu CL, Chiu CH. High-intensity intermittent exercise increases fat oxidation rate and reduces postprandial triglyceride concentrations. Nutrients 2018; 10: E492