Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Bao-Jun Zhang; Wen-Wei Fu; Rong Wu; Jin-Ling Yang; Cai-Yun Yao; Bing-Xiong Yan; Hong-Sheng Tan; Chang-Wu Zheng; Zhi-Jun Song; Hong-Xi Xu

doi:10.1055/a-0828-9831

Planta Medica, Table of Contents

Planta Med 2019; 85(06): 444-452
DOI: 10.1055/a-0828-9831

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Bao-Jun Zhang^*

¹School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China

²Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China

³Department of Pharmacy, ShangHai PuTuo District People Hospital, Shanghai, Peopleʼs Republic of China

,

Wen-Wei Fu^*

¹School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China

²Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China

,

Rong Wu

¹School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China

²Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China

,

Jin-Ling Yang

¹School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China

²Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China

,

Cai-Yun Yao

⁴Guangxi Botanical Garden of Medicinal Plants, Nanning, Peopleʼs Republic of China

,

Bing-Xiong Yan

⁴Guangxi Botanical Garden of Medicinal Plants, Nanning, Peopleʼs Republic of China

,

Hong-Sheng Tan

¹School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China

²Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China

,

Chang-Wu Zheng

¹School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China

²Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China

,

Zhi-Jun Song

⁴Guangxi Botanical Garden of Medicinal Plants, Nanning, Peopleʼs Republic of China

,

Hong-Xi Xu

¹School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China

²Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China

› Author Affiliations

Abstract

Six new prenylated xanthones (1–6) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1 and 15–17 showed moderate inhibitory effects on tumor cell growth, with IC₅₀s ranging from 3.7 to 14.7 µM.

Key words

Garcinia bracteata - Clusiaceae - prenylated xanthones - cytotoxicity

Full Text

References

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