Four New Cytotoxic Arborinane-Type Triterpenes from the Endolichenic Fungus Myrothecium inundatum

Buddha Bahadur Basnet; Li Liu; Baosong Chen; Yerlan Melsuly Suleimen; Haiyang Yu; Shouyu Guo; Li Bao; Jinwei Ren; Hongwei Liu

doi:10.1055/a-0855-4051

Planta Medica, Table of Contents

Planta Med 2019; 85(09/10): 701-707
DOI: 10.1055/a-0855-4051

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Four New Cytotoxic Arborinane-Type Triterpenes from the Endolichenic Fungus Myrothecium inundatum

Buddha Bahadur Basnet^*

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China

²International College, University of Chinese Academy of Sciences, Beijing, China

,

Li Liu^*

⁴Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China

,

Baosong Chen^*

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China

³Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

,

Yerlan Melsuly Suleimen

⁵Institute of Applied Chemistry, Chemistry Department of L. N. Gumilyov Eurasian National University, Astana, Republic of Kazakhstan

,

Haiyang Yu

⁶Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China

,

Shouyu Guo

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China

,

Li Bao

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China

³Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

,

Jinwei Ren

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China

³Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

,

Hongwei Liu

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China

³Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

› Author Affiliations

Abstract

Two new arborinane-type triterpenes, myrotheols A (1) and B (2), two new arborinane-type glycosides, myrothesides C (3) and D (4), together with four known diterpenes (5 – 8) were isolated from the ethyl acetate extract of the endolichenic fungus Myrothecium inundatum. The structures of new compounds 1 – 4 were elucidated by NMR and MS analyses. The absolute configuration of 1 was assigned by a single-crystal X-ray diffraction experiment. Compounds 3 and 4 represent the first two natural 4-O-methyl-α-D-mannosides. Compounds 1 – 8 exhibited cytotoxicity against K562 and RKO human cancer cell lines.

Key words

endolichenic fungi - Myrothecium inundatum - Stachybotryaceae - arborinane-type - riterpenes - diterpenes - cytotoxicity

Full Text

References

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