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Zeitschrift für Phytotherapie 2019; 40(04): 187-191
DOI: 10.1055/a-0879-8764
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© Georg Thieme Verlag KG Stuttgart · New York

Leonurus cardiaca L., das Echte Herzgespann

Xinting Zhang
,
Matthias F Melzig
Further Information

Publication History

Publication Date:
19 September 2019 (online)

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Zusammenfassung

Leonurus cardiaca L. ist eine seit Langem genutzte europäische traditionelle Heilpflanze, die v. a. Terpene, Flavonoide, Stachydrin und das Pseudoalkaloid Leonurin enthält. Zubereitungen aus der Arzneidroge besitzen sedative, blutdrucksenkende, antioxidative bzw. entzündungshemmende Wirkungen. Ein therapeutischer Einsatz im Rahmen einer traditionellen Anwendung erfolgt bei nervösen Herzbeschwerden, Schilddrüsenüberfunktion und klimakterischen Beschwerden. Zurzeit gibt es nur unzureichende klinische Studien, und die den Wirkungen zugrundeliegenden Mechanismen sind noch nicht vollständig geklärt.

Abstract

Leonurus cardiaca L., Motherwort

Leonurus cardiaca L. (Lamiaceae) is a perennial plant with a long history in European traditional medicine. The drug contains terpenes, flavonoids, stachydrine and the pseudoalkaloid leonurine. Preparations of the herbal drug induce sedative, hypotensive, antioxidative and anti-inflammatory effects. Traditionally, motherwort is used for treating nervous heart complaints, hyperthyroidism and menopausal conditions. Currently only insufficient clinical studies are available and the mechanisms for biological activities have not yet been fully clarified.

Schlüsselwörter

Leonurus cardiaca L. - Echtes Herzgespann - Lamiaceae - traditionelle Medizin - Pharmakologie

Key words

Leonurus cardiaca L. - motherwort - traditional medicine - pharmacology
 

  • Literatur

  • 1 Blaschek W. Wichtl - Teedrogen und Phytopharmaka. 6.. Aufl. Stuttgart: WVG; 2015: 370-371
    Search in Google Scholar
  • 2 Jänicke C, Grünwald J, Brendler T. Handbuch Phytotherapie. Stuttgart: WVG; 2003: 225
    Search in Google Scholar
  • 3 Aichele D, Schwegler HW. Die Blütenpflanzen Mitteleuropas. Stuttgart: Franckh-Kosmos; 1995: 229
    Search in Google Scholar
  • 4 Madaus G. Lehrbuch der biologischen Heilmittel. Bd. 2.. [Nachdruck]. Hildesheim, New York: Georg Olms Verlag; 1979: 1738-1742
    Search in Google Scholar
  • 5 Sauerhoff F. Etymologisches Wörterbuch der Pflanzennamen. Stuttgart: WVG; 2003: 359-360
    Search in Google Scholar
  • 6 Schantz P. Weißdorn und Herzgespann. Kassel: kassel university press; 2009: 75-93
    Search in Google Scholar
  • 7 Lans C, Turner N, Brauer G. et al. Medicinal plants used in British Columbia, Canada for reproductive health in pets. Prev Vet Med 2009; 90: 268-273
    CrossrefPubMedSearch in Google Scholar
  • 8 Wojtyniak K, Szymański M, Matławska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013; 27: 1115-1120
    CrossrefPubMedSearch in Google Scholar
  • 9 European Medicines Agency. Assessment Report on Leonurus cardiaca L., herba. EMA / HMPC / 127430 / 2010; 16 September 2010
    PubMed
  • 10 Xu D, Chen M, Ren X. et al. Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-κB signaling pathway. Fitoterapia 2014; 97: 148-155
    CrossrefPubMedSearch in Google Scholar
  • 11 Wu H, Dai A, Chen X. et al. Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis. Int Immunopharmacol 2018; 61: 156-161
    CrossrefPubMedSearch in Google Scholar
  • 12 Rauwald HW, Savtschenko A, Merten A. et al. GABAA receptor binding assays of standardized Leonurus cardiaca and Leonurus japonicus extracts as well as their isolated constituents. Planta Med 2015; 81: 1103-1110
    Thieme ConnectPubMedSearch in Google Scholar
  • 13 Shikov AN, Pozharitskaya ON, Makarov VG. et al. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders. Phytother Res 2011; 25: 540-543
    CrossrefPubMedSearch in Google Scholar
  • 14 Rezaee-Asl M, Sabour M, Nikoui V. et al. The study of analgesic effects of Leonurus cardiaca L. in mice by formalin, tail flick and hot plate tests. Int Sch Res Notices 2014; 2014: 687-697
    PubMedSearch in Google Scholar
  • 15 Milkowska-Leyck K, Filipek B, Strzelecka H. Pharmacological effects of lavandulifolioside from Leonurus cardiaca . J Ethnopharmacol 2002; 80: 85-90
    CrossrefPubMedSearch in Google Scholar
  • 16 Ritter M, Melichar K, Strahler S. et al. Cardiac and electrophysiological effects of primary and refined extracts from Leonurus cardiaca L. (Ph. Eur.). Planta Med 2010; 76: 572-582
    Thieme ConnectPubMedSearch in Google Scholar
  • 17 Bernatoniene J, Kopustinskiene DM, Jakstas V. et al. The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart. Planta Med 2014; 80: 525-532
    Thieme ConnectPubMedSearch in Google Scholar
  • 18 Chen HH, Zhao P, Zhao WX. et al. Stachydrine ameliorates pressure overload-induced diastolic heart failure by suppressing myocardial fibrosis. Am J Transl Res 2017; 9: 4250-4260
    PubMedSearch in Google Scholar
  • 19 Micota B, Sadowska B, Podsędek A. et al. Leonurus cardiaca L. herb – a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis. Acta Biochim Pol 2014; 61: 385-388
    PubMedSearch in Google Scholar
  • 20 Micota B, Sadowska B, Podsedek A. et al. Is it true that plant-derived polyphenols are always beneficial for the human? In vitro study on Leonurus cardiaca extract properties in the context of the pathogenesis of Staphylococcus aureus infections. J Med Microbiol 2016; 65: 1171-1181
    CrossrefPubMedSearch in Google Scholar
  • 21 Sadowska B, Micota B, Rózalski M. et al. The immunomodulatory potential of Leonurus cardiaca extract in relation to endothelia cells and platelets. Innate Immun 2017; 23: 285-295
    CrossrefPubMedSearch in Google Scholar