Subscribe to RSS
DOI: 10.1055/a-0885-7169
Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis?
Publication History
received 01 February 2019
accepted 26 March 2019
Publication Date:
09 May 2019 (online)
![](https://www.thieme-connect.de/media/hmr/201905/lookinside/thumbnails/2019-03-0084_10-1055-a-0885-7169-1.jpg)
Abstract
Dyslipidemia and dyslipoproteinemia are common causes of metabolic and cardiovascular diseases. On the other hand, intracellular bacteria, such as Borrelia burgdorferi, utilize host lipids to survive and disseminate within the host. Recent data suggest that elevated lipids are a contributing factor to the maintenance and severity of Lyme disease and its complications. Here we review and discuss the role of lipids in Borreliosis and report on a pilot trial to examine the potential roles of circulating lipids and lipoproteins in patients with Borrelia infection. In this analysis we assessed the clinical and lipid profiles of 519 patients (319 women, 200 men) with a proven history of Lyme disease, before and after an extracorporeal double membrane filtration. Lipid profiles pre- and post-apheresis were analyzed in conjunction with clinical symptoms and parameters of inflammation. Circulating cholesterol, triglycerides, LDL, LP(a), and other inflammatory lipids were significantly reduced after the apheresis, while symptoms of the disorder and bioindexes of inflammation such as CRP improved. Further studies should be initiated to investigate the possibly causal relation between Lyme disease and circulating lipids and to design appropriate therapeutic strategies.
-
References
- 1 Toledo A, Benach JL. Hijacking and Use of host lipids by intracellular pathogens. Microbiol Spectr 2015; 3 (6) DOI: 10.1128/microbiolspec.VMBF-0001-2014.
- 2 Crowley JT, Toledo AM, LaRocca TJ. et al. Lipid exchange between Borrelia burgdorferi and host cells. PLoS Pathog 2013; 9: e1003109
- 3 Toledo A, Monzon JD, Coleman JL. et al. Hypercholesterolemia and ApoE deficiency result in severe infection with Lyme disease and relapsing-fever Borrelia. Proc Natl Acad Sci USA 2015; 112: 5491-5496
- 4 Volzke H, Wolff B, Ludemann J. et al. Seropositivity for anti-Borrelia IgG antibody is independently associated with carotid atherosclerosis. Atherosclerosis 2006; 184: 108-112
- 5 Makris GC, Makris MC, Wilmot VV. et al. The role of infection in carotid plaque pathogenesis and stability: the clinical evidence. Curr Vasc Pharmacol 2010; 8: 861-872
- 6 Eldin C, Raffetin A, Bouiller K. et al. Review of European and American guidelines for the diagnosis of Lyme borreliosis. Med Mal Infect 2019; 49: 121-132
- 7 Luczaj W, Domingues P, Domingues MR. et al. Phospholipidomic analysis reveals changes in sphingomyelin and lysophosphatidylcholine profiles in plasma from patients with neuroborreliosis. Lipids 2017; 52: 93-98
- 8 Luczaj W, Moniuszko-Malinowska A, Domingues P. et al. Plasma lipidomic profile signature of rheumatoid arthritis versus Lyme arthritis patients. Arch Biochem Biophys 2018; 654: 105-114
- 9 Schmocker C, Kassner U, Ostermann AI. et al. Effect of different lipid apheresis methods on plasma polyunsaturated fatty acids. Atheroscler Suppl 2017; 30: 193-199
- 10 Kozik-Jaromin J, Roseler E, Heigl F. et al. Safety aspects of lipidapheresis using DALI and MO. Atheroscler Suppl 2017; 30: 225-231
- 11 Schatz U, Tselmin S, Muller G. et al. Most significant reduction of cardiovascular events in patients undergoing lipoproteinapheresis due to raised Lp(a) levels - A multicenter observational study. Atheroscler Suppl 2017; 30: 246-252
- 12 Straube R, Kingreen H. Lipoprotein (a) immunapheresis in the treatment of familial lipoprotein (a) hyperlipoproteinemia in a patient with coronary heart disease. Ther Apher 1998; 2: 243-245
- 13 Boffa MB, Koschinsky ML. Oxidized phospholipids as a unifying theory for lipoprotein(a) and cardiovascular disease. Nat Rev Cardiol 2019; Jan 23 DOI: 10.1038/s41569-018-0153-2. [Epub ahead of print]
- 14 Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol 2015; 15: 511-523
- 15 Brown CR, Dennis EA. Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis. Biochimie 2017; 141: 86-90
- 16 Tselmin S, Schmitz G, Julius U. et al. Acute effects of lipid apheresis on human serum lipidome. Atheroscler Suppl 2009; 10: 27-33
- 17 Li S, Vytopil M, Hreib K. et al. Lyme disease presenting as multiple ischaemic strokes. Pract Neurol 2015; 15: 284-288
- 18 Kostic T, Momcilovic S, Perisic ZD. et al. Manifestations of Lyme carditis. Int J Cardiol 2017; 232: 24-32
- 19 Londono D, Cadavid D. Bacterial lipoproteins can disseminate from the periphery to inflame the brain. Am J Pathol 2010; 176: 2848-2857
- 20 Zlotnikov N, Javid A, Ahmed M. et al. Infection with the Lyme disease pathogen suppresses innate immunity in mice with diet-induced obesity. Cell Microbiol 2017; 19 (5) DOI: 10.1111/cmi.12689.