MRI Brain Changes After Marathon Running: Results of the Berlin Beat of Running Study

Juliane Herm; Karl Georg Haeusler; Claudia Kunze; Matthias Krüll; Lars Brechtel; Jürgen Lock; Peter U. Heuschmann; Wilhelm Haverkamp; Hauke Heekeren; Thomas Liman; Matthias Endres; Jochen B. Fiebach; Gerhard Jan Jungehulsing

doi:10.1055/a-0958-9548

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2019; 40(13): 856-862
DOI: 10.1055/a-0958-9548

Clinical Sciences

MRI Brain Changes After Marathon Running: Results of the Berlin Beat of Running Study

Juliane Herm

¹Department of Neurology, Charité, Universitätsmedizin Berlin, Berlin, Germany

²Center for Stroke Research, Charité Universitätsmedizin Berlin, Berlin, Germany

,

Karl Georg Haeusler

³Department of Neurology, Universitätsklinikum Würzburg, Würzburg, Germany

,

Claudia Kunze

²Center for Stroke Research, Charité Universitätsmedizin Berlin, Berlin, Germany

,

Matthias Krüll

⁴SMS Medical Institute Berlin GmbH, Berlin, Germany

⁵SCC EVENTS GmbH, Berlin, Germany

,

Lars Brechtel

⁶Carl Remigius Medical School, Physician Assistance, Hamburg, Germany

⁷Berlin Academy of Sports Medicine, Sports Medicine, Berlin, Germany

,

Jürgen Lock

⁴SMS Medical Institute Berlin GmbH, Berlin, Germany

⁵SCC EVENTS GmbH, Berlin, Germany

,

Peter U. Heuschmann

⁸Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany

⁹Clinical Trial Center Würzburg, University of Würzburg, Würzburg, Germany

¹⁰Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany

,

Wilhelm Haverkamp

¹¹Department of Cardiology, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany

,

Hauke Heekeren

¹²Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany

,

Thomas Liman

¹Department of Neurology, Charité, Universitätsmedizin Berlin, Berlin, Germany

²Center for Stroke Research, Charité Universitätsmedizin Berlin, Berlin, Germany

,

Matthias Endres

¹Department of Neurology, Charité, Universitätsmedizin Berlin, Berlin, Germany

²Center for Stroke Research, Charité Universitätsmedizin Berlin, Berlin, Germany

¹³Charité Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany

¹⁴Charité Universitätsmedizin Berlin, Excellence Cluster NeuroCure, Berlin, Germany

¹⁵German Center for Cardiovascular Research (DZHK), Berlin, Germany

,

Jochen B. Fiebach^*

²Center for Stroke Research, Charité Universitätsmedizin Berlin, Berlin, Germany

,

Gerhard Jan Jungehulsing^*

¹⁶Department of Neurology, Jüdisches Krankenhaus Berlin, Berlin, Germany

› Institutsangaben

Abstract

Several studies report neurological complications such as brain injury induced by ischemia or edema following exhaustive endurance sport. We aimed to detect the frequency of acute brain lesions after a marathon race. In the prospective observational Berlin Beat of Running study, 110 experienced endurance athletes underwent 3-Tesla brain MRI exams 2–3 days prior and within 2 days after a marathon run. MRI results were compared to an age- and sex-matched control group of 68 non-athletes, including the “Age-Related White Matter Changes” (ARWMC) scale to assess white matter lesions (WML) in the brain. 108 athletes (median age 48 years, 24% female, 8% with hypertension; 0% with diabetes) completed the race. No athlete reported neurological deficits, but a single acute ischemic lesion was detected in diffusion-weighted MRI after the race in one athlete. No other acute brain lesions compared to prior MRI were found. An ARWMC score ≥4 was found in 15% of athletes and 12% of non-athletic controls (p=0.7). Chronic ischemic lesions were not found in athletes but in four controls (6%) (p=0.02). In conclusion, acute ischemic brain lesions may be found in endurance runners. Every seventh endurance athlete and every ninth control showed evidence for substantial white matter lesions.

Key words

marathon - athletes - edema - stroke - ischemic brain lesions - magnetic resonance imaging

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Referenzen

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