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Tierarztl Prax Ausg K Kleintiere Heimtiere 2019; 47(05): 1-8
DOI: 10.1055/a-1000-5121
Case Report
© Georg Thieme Verlag KG Stuttgart · New York

Successful treatment of a mucous membrane pemphigoid in a young dog

Erfolgreiche Behandlung eines mukokutanen Pemphigoids bei einem jungen Hund
Laura Udraite Vovk
1   Small Animal Medicine Clinic, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany
,
Christoph J. Klinger
1   Small Animal Medicine Clinic, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany
,
Teresa M. S. A. Böhm
1   Small Animal Medicine Clinic, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany
,
Natalie K. Y. Gedon
1   Small Animal Medicine Clinic, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany
,
Sonya V. Bettenay
2   Tierdermatologie Deisenhofen, Oberhaching, Germany
,
Ralf. S. Mueller
1   Small Animal Medicine Clinic, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany
› Author Affiliations
Further Information

Publication History

17 December 2018

02 May 2019

Publication Date:
18 October 2019 (online)

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Abstract

Mucous membrane pemphigoid was diagnosed in a 2.5-year-old male intact foxhound-beagle cross which was presented with an acute onset of non-pruritic, multifocal, slowly progressive erosive-ulcerative dermatitis predominantly affecting the nasal planum, eyelids and muzzle with multiple vesicles on the inner pinnae, oral mucosa and tongue. The diagnosis was based on clinical signs and histological examination of skin biopsies. The patient did not respond to immunosuppressive prednisolone therapy, but went into complete remission with oral doxycycline and niacinamide and stayed in remission on long-term exclusive niacinamide treatment.

Zusammenfassung

Bei einem 2,5-jährigen, männlich-intakten Foxhound-Beagle-Mischling mit akuter, multifokaler, langsam fortschreitender, erosiv-ulzerierender Dermatitis ohne Juckreiz wurde basierend auf klinischen Symptomen und histologischer Untersuchung von Hautbioptaten ein mukokutanes Pemphigoid diagnostiziert. Betroffen waren Nasenspiegel, Augenlider und Schnauze. Bläschen fanden sich auch an Ohreninnenseiten, Maulschleimhaut und Zunge. Der Patient sprach nicht auf eine immunsuppressive Therapie mit Prednisolon an. Mit oraler Gabe von Doxycyclin und Niacinamid ließ sich eine vollständige Remission erreichen und die Erkrankung blieb unter langfristiger ausschließlicher Therapie mit Niacinamid in Remission.

Key words

Subepidermal blistering - autoimmune skin disease - auto-antibodies - doxycycline - niacinamide vesicle - biopsy

Schlüsselwörter

Subepidermale Blasenbildung - autoimmune Hauterkrankung - Autoantikörper - Doxycyclin - Niacinamid - Bläschen - Biopsie
 

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