Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000014.xml
Erfahrungsheilkunde 2019; 68(05): 278-292
DOI: 10.1055/a-1001-9336
DOI: 10.1055/a-1001-9336
Wissen
Zinkmangel im Fokus: Ursachen, Symptome, Diagnose und Therapie
Further Information
Publication History
Publication Date:
17 October 2019 (online)
Zusammenfassung
Das essenzielle Spurenelement Zink ist für zahlreiche Prozesse in unserem Körper unentbehrlich. Diese Übersicht soll helfen, einen Zinkmangel besser zu erkennen und zu behandeln.
Abstract
The essential trace element zinc is indispensable for numerous processes in our body. This overview is intended to help identifying and treating a zinc deficiency more effectively.
-
Literatur
- 1 Ambati J, Ambati BK. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Archives of ophthalmology 2001; 119: 1417-1436
- 2 Alker W, Haase H. Zinc and Sepsis. Nutrients 2018; 10 (08) 976
- 3 Bae YS, Hill ND, Bibi Y. et al. Innovative uses for zinc in dermatology. Dermatologic clinics 2010; 28: 587-97
- 4 Biesalski HK. Vitamine und Minerale: Indikation, Diagnostik, Therapie. 1. Aufl.. Stuttgart: Thieme; 2016
- 5 Biesalski HK, Adam O. Ernährungsmedizin: nach dem Curriculum Ernährungsmedizin der Bundesärztekammer. Stuttgart: Thieme; 2004
- 6 Biesalski HK, Pirlich M, Bischoff SC. et al. Ernährungsmedizin: Nach dem Curriculum Ernährungsmedizin der Bundesärztekammer. 5. Aufl.. Stuttgart: Thieme; 2018
- 7 Bilici M, Yildirim F, Kandil S. et al. Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Progress in neuro-psychopharmacology & biological psychiatry 2004; 28: 181-190
- 8 Brewer GJ. Copper excess, zinc deficiency, and cognition loss in Alzheimer’s disease. BioFactors (Oxford, England) 2012; 38: 107-113
- 9 Brown KH, Peerson JM, Baker SK. et al. Preventive zinc supplementation among infants, preschoolers, and older prepubertal children. Food and nutrition bulletin 2009; 30: 12-40
- 10 Classen H-G, Gröber U, Löw D. et al. Zink-Mangel – Symptome, Ursachen, Diagnose und Therapie. MMP 2011; 3: 87-95
- 11 Coudray C, Bellanger J, Castiglia-Delavaud C. et al. Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. Eur J Clin Nutr 1997; 51: 375-380
- 12 Deutsche Gesellschaft für Ernährung e. V.. Referenzwerte Zink. Im Internet: https://www.dge.de/wissenschaft/referenzwerte/zink/ Stand: 09.2019
- 13 DocCheck Flexikon. Spurenelement. Im Internet: https://flexikon.doccheck.com/de/Spurenelement Stand: 01.05.2019
- 14 Dreno B, Moyse D, Alirezai M. et al. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. Dermatology (Basel, Switzerland) 2001; 203: 135-340
- 15 Elsenhals B. Zink. In: Biesalski HK, Köhrle J, Schümann K. Hrsg. Vitamine, Spurenelemente und Mineralstoffe. Stuttgart/New York: Thieme; 2002: 151-160
- 16 European Food Safety Authority. Hrsg. Scientific Committee on Food, Scientific Panel on Dietetic Products, Nutrition and Allergies. Tolerable Upper Intake Levels for Vitamins and Minerals: Opinion of the Scientifiic Committee on Food on the Tolerable upper Intake Level of Zinc (05.03.2002). In Internet: http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf Stand: 02.2019
- 17 European Food Safety Authority (EFSA). Scientific Opinion on Dietary Reference Values for zinc. EFSA Journal 2014; 12: 3844
- 18 Florea D, Molina-López J, Hogstrand C. et al. Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS). Journal of trace elements in medicine and biology organ of the Society for Minerals and Trace Elements (GMS) 2018; 49: 202-209
- 19 Food an Nutrition Board, Institute of Medicine National Academies. Dietary Reference Intakes (DRIs): Tolerable Upper Intake Levels, Elements. Im Internet: http://nationalacademies.org/hmd/~/media/Files/Activity%20Files/Nutrition/DRI-Tables/4_%20UL%20Values_Vitamins%20and%20Elements.pdf?la=en 2001 Stand: 02.2019
- 20 Ghishan FK, Kiela PR. Vitamins and Minerals in Inflammatory Bowel Disease. Gastroenterology clinics of North America 2017; 46: 797-808
- 21 Gibson RS. Content and bioavailability of trace elements in vegetarian diets. The American journal of clinical nutrition 1994; 59: 1223S-1232S
- 22 Gibson RS, Hess SY, Hotz C. et al. Indicators of zinc status at the population level: a review of the evidence. The British journal of nutrition 2008; 99 (03) 14-23
- 23 Gibson RS, King JC, Lowe N. A Review of Dietary Zinc Recommendations. Food and nutrition bulletin 2016; 37: 443-460
- 24 Grahn BH, Paterson PG, Gottschall-Pass KT. et al. Zinc and the eye. J Am Coll Nutr 04/2001; 20 (02) 106-118 2001; 20: 106–118
- 25 Gröber U. Arzneimittel und Mikronährstoffe. 4. Aufl.. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2018
- 26 Grüngreiff K, Reinhold D, Wedemeyer H. The role of zinc in liver cirrhosis. Annals of hepatology 2016; 15: 7-16
- 27 Haase H, Rink L. The immune system and the impact of zinc during aging. Immunity & ageing 2009; 6: 9
- 28 Hahn A, Ströhle A, Wolters M. et al. Ernährung: Physiologische Grundlagen, Prävention, Therapie. 3. Aufl.. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2016
- 29 Hahn A, Schuchardt JP. Physiologische und klinische Bedeutung von Zink. Schweizer Zeitschrift für Ernährungsmedizin 2010; 1: 35-41
- 30 Han YM, Yoon H, Lim S. et al. Risk Factors for Vitamin D, Zinc, and Selenium Deficiencies in Korean Patients with Inflammatory Bowel Disease. Gut and liver 2017; 11: 363-369
- 31 Hess SY, Lönnerdal B, Hotz C. et al. Recent advances in knowledge of zinc nutrition and human health. Food and nutrition bulletin 2009; 30: 5-11
- 32 Hess SY, Peerson JM, King JC. Use of serum zinc concentration as an indicator of population zinc status. Food and nutrition bulletin 2007; 28: 403-429
- 33 Himoto T, Masaki T. Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease. Nutrients 2018; 10 (01) E88
- 34 Hülsmann O, Ströhle A, Wolters M. et al. Mineralstoffe. DAZ 2005; 8: 52
- 35 Hunt JR, Matthys LA, Johnson LK. Zinc absorption, mineral balance, and blood lipids in women consuming controlled lactoovovegetarian and omnivorous diets for 8 wk. The American journal of clinical nutrition 1998; 67: 421-430
- 36 Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press; 2001
- 37 Jayawardena R, Ranasinghe P, Galappatthy P. et al. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetology & metabolic syndrome 2012; 4: 13
- 38 Karabacak E, Aydin E, Kutlu A. et al. Erythrocyte zinc level in patients with atopic dermatitis and its relation to SCORAD index. Postepy dermatologii i alergologii 2016; 33: 349-352
- 39 Kim JE, Yoo SR, Jeong MG. et al. Hair zinc levels and the efficacy of oral zinc supplementation in patients with atopic dermatitis. Acta dermato-venereologica 2014; 94: 558-562
- 40 King JC, Brown KH, Gibson RS. et al. Biomarkers of Nutrition for Development (BOND)-Zinc Review. The Journal of nutrition 2016; 146: 858S-885S
- 41 King JC, Shames DM, Lowe NM. et al. Effect of acute zinc depletion on zinc homeostasis and plasma zinc kinetics in men. The American journal of clinical nutrition 2001; 74: 116-124
- 42 King JC, Shames DM, Woodhouse LR. Zinc homeostasis in humans. The Journal of nutrition 2000; 130: 1360S-1366S
- 43 King JC. Determinants of maternal zinc status during pregnancy. 2000; 71 (05) 1334S-143S
- 44 King JC. Enhanced zinc utilization during lactation may reduce maternal and infant zinc depletion. Am J Clin Nutr 2002; 75: 2-3
- 45 Lamprecht G, Pape UF, Witte M. et al. S3-Leitlinie der Deutschen Gesellschaft für Ernährungsmedizin e. V. in Zusammenarbeit mit der AKE, der GESKES und der DGVS Klinische Ernährung in der Gastroenterologie (Teil 3) – Chronisches Darmversagen. Aktuel Ernahrungsmed 2014; 39: e57-e71
- 46 Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Review 2012; 6: CD005436 Im Internet: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD005436.pub5/full 2016; Stand: 03.2019
- 47 Lee HH, Prasad AS, Brewer GJ. et al. Zinc absorption in human small intestine. Am J Physiol 1989; 256: G87-F91
- 48 Lönnerdal B. Dietary factors influencing zinc absorption. The Journal of nutrition 2000; 130: 1378S-1383S
- 49 Maggini S, Beveridge S, Suter M. A combination of high-dose vitamin C plus zinc for the common cold. The Journal of international medical research 2012; 40: 28-42
- 50 Maggini S, Maldonado P, Cardim P. et al. Vitamins C, D and Zinc: Synergistic Roles in Immune Function and Infections. Vitamin & Minerals 2017; 167 Im Internet: https://www.omicsonline.org/open-access/vitamins-c-d-and-zinc-synergistic-roles-in-immune-function-and-infections-2376–1318–1000167.pdf Stand: 03.2017
- 51 Maret W, Sandstead HH. Zinkbedarf und Risiko und Nutzen einer Zinksupplementierung. Perspectives in Medicine 2014; 2: 3-18
- 52 Martínez-Cengotitabengoa M, González-Pinto A. Nutritional supplements in depressive disorders. Actas Esp Psiquiatr 2017; 45: 8-15
- 53 Maverakis E, Fung MA, Lynch PJ. et al. Acrodermatitis enteropathica and an overview of zinc metabolism. Journal of the American Academy of Dermatology 2007; 56: 116-124
- 54 Max Rubner Institut, Bundesforschungsinstitut für Ernährung und Lebensmittel. Nationale Verzehrsstudie II, Ergebnisbericht, Teil 2 (2008). Im Intenet: https://www.bmel.de/DE/Ernaehrung/GesundeErnaehrung/_Texte/NationaleVerzehrsstudie_Zusammenfassung.html Stand: 03.2019
- 55 McClain CJ, Adams L, Shedlofsky S. Zinc and the gastrointestinal tract. In: Prasad AS. Hrsg. Essential and toxic trace elements in human health and disease. New York: Alan R. Liss Inc.; 1988: 55-73
- 56 Meydani SN, Barnett JB, Dallal GE. et al. Serum zinc and pneumonia in nursing home elderly. The American journal of clinical nutrition 2007; 86: 1167-1173
- 57 Milne DB, Davis CD, Nielsen FH. Low dietary zinc alters indices of copper function and status in postmenopausal women. Nutrition 2001; 17: 701-708
- 58 Mocchegiani E, Romeo J, Malavolta M. et al. Zinc: dietary intake and impact of supplementation on immune function in elderly. Age (Dordrecht, Netherlands) 2013; 35: 839-860
- 59 Momen-Heravi M, Barahimi E, Razzaghi R. et al. The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. Wound repair and regeneration official publication of the Wound Healing Society [and] the European Tissue Repair Society 2017; 25: 512-520
- 60 Neve J, Hanocq M, Peretz A. et al. Etude de quelques facteurs influencant la biodisponibilité du zinc dans les formes pharmaceutiques à usage oral. J Pharm Belg 1993; 48: 5-11
- 61 Pécoud A, Donzel P, Schelling JL. Effect of foodstuffs on the absorption of zinc sulfate. Clin Pharmacol Ther 1975; 17: 469-474
- 62 Pietrzik K, Loew D. Pharmakodynamik und Pharmakokinetik von Zink. Z Geriatrie 1991; 4: 89-91
- 63 Prasad A. Discovery of human zinc deficiency: its impact on human health and disease. Advances in nutrition (Bethesda, Md.) 2013; 4: 176-190
- 64 Prasad A, Beck F, Bao B. et al. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. The American journal of clinical nutrition 2007; 85: 837-844
- 65 Prasad AS. Discovery of Zinc Deficiency in Humans and its Impact Fifty Years Later. In: Rink L. Hrsg. Zinc in Human Health. Amsterdam: IOS Press; 2011: 7-28
- 66 Roohani N, Hurrell R, Kelishadi R. et al. Zinc and its importance for human health: An integrative review. Journal of research in medical sciences the official journal of Isfahan University of Medical Sciences 2013; 18: 144-157
- 67 Rükgauer M. Methode zur Bestimmung der Spurenelementversorgung. Untersuchung bei Patienten mit Diabetes mellitus: Dissertation. Universität Hohenheim; 1999: 49
- 68 Salehi B, Mohammadbeigi A, Sheykholeslam H. et al. Omega-3 and Zinc supplementation as complementary therapies in children with attention-deficit/hyperactivity disorder. Journal of research in pharmacy practice 2016; 5: 22-26
- 69 Sandstead HH, Penland JG, Alcock NW. et al. Effects of repletion with zinc and other micronutrients on neuropsychologic performance and growth of Chinese children. The American journal of clinical nutrition 1998; 68: 470S-475S
- 70 Schuchardt JP, Hahn A. Die Bedeutung von Eisen, Zink undSelen in der Ernährung des Menschen. Ernährungs Umschau 2010; 57: 538-549
- 71 Science M, Johnstone J, Roth DE. et al. Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. CMAJ Canadian Medical Association journal = journal de l’Association medicale canadienne 2012; 184: E551-561
- 72 Singh M, Das RR. Zinc for the common cold. The Cochrane database of systematic reviews 2013; 6: CD001364
- 73 Siwek M, Dudek D, Schlegel-Zawadzka M. et al. Serum zinc level in depressed patients during zinc supplementation of imipramine treatment. Journal of affective disorders 2010; 126: 447-452
- 74 Souci SW, Fachmann W, Kraut H. et al. Food composition and nutrition tables: Die Zusammensetzung der Lebensmittel, Nährwert-Tabellen = La composition des aliments, tableaux des valeurs nutritives. 7. Aufl.. Stuttgart: MedPharm Scientific Publ.; 2008
- 75 Sun Q, van Dam, Rob M. et al. Prospective study of zinc intake and risk of type 2 diabetes in women. Diabetes care 2009; 32: 629-634
- 76 Takahashi H, Nakazawa M, Takahashi K. et al. Effects of zinc deficient diet on development of atopic dermatitis-like eruptions in DS-Nh mice. Journal of dermatological science 2008; 50: 31-39
- 77 Tran CD, Miller LV, Krebs NF. et al. Zinc absorption as a function of the dose of zinc sulfate in aqueous solution. The American journal of clinical nutrition 2004; 80: 1570-1573
- 78 Watson WS, Mitchell KG, Lyon TD. et al. A two-compartment model for zinc in humans. J Trace Elem Med Biol 1999; 13: 141-149
- 79 Wessels I, Maywald M, Rink L. Zinc as a Gatekeeper of Immune Function. Nutrients 2017; 9 (12) E1286
- 80 World Health Organization. Zinc supplementation in the management of diarrhoea (04.2011). Im Internet: https://www.who.int/elena/titles/zinc_diarrhoea/en/ Stand: 03.2019
- 81 Wörwag Pharma GmbH & Co.KG. Fachinformation Zinkorot (2014). Im Internet: https://www.zinkorot.de/www/woerwagpharma-zinkorot-25-gi.pdf Stand: 08.2019
- 82 Yang R, Zhang Y, Gao W. et al. Blood Levels of Trace Elements in Children with Attention-Deficit Hyperactivity Disorder: Results from a Case-Control Study. Biological trace element research 2019; 187: 376-382