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Planta Med 2020; 86(03): 205-211
DOI: 10.1055/a-1081-7220
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Phenylpropanoid and Iridoid Glucosides from the Whole Plant of Hemiphragma heterophyllum and Their alpha-Glucosidase Inhibitory Activities

Yan-Hong Li
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China
,
Jia-Meng Dai
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China
,
Cui Yang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China
,
Meng-Yuan Jiang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China
,
Yong Xiong
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China
,
Yu-Kui Li
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China
,
Hong-Rui Li
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China
,
Kai Tian
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China
,
Xiang-Zhong Huang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China
› Author AffiliationsSupported by: Training Programs of Innovation and Entrepreneurship for Undergraduates 2018JWC-DC-45
Supported by: National Natural Science Foundation of China 81960783
Supported by: Yunnan Provincial Applied Basic Research Projects 2017FD122
Further Information

Publication History

received 27 May 2019
revised 27 November 2019

accepted 06 December 2019

Publication Date:
09 January 2020 (online)

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Abstract

Three phenylpropanoid glucosides (1 – 3) and one iridoid glucoside (11), together with eleven known glucosides, were isolated from the ethanol extract of the whole plant of Hemiphragma heterophyllum. Their structures were elucidated by means of 1D and 2D NMR spectroscopy, HRMS, and chemical methods. All compounds except 11 and 13 – 15 showed varying degrees of α-glucosidase inhibitory activity. Compounds 5, 9, and 12 were marginally active in the bioassay, while compounds 1 – 4, 6 – 8, and 10 exhibited appreciable inhibitory activity with an IC50 value of 33.6 ~ 83.1 µM, which was much lower than that of the positive control acarbose (IC50 = 310.8 µM).

Key words

Hemiphragma heterophyllum - Scrophulariaceae - phenylpropanoid glucosides - iridoid glucosides - α-glucosidase inhibitor activity

Supporting Information

    The IR, UV, HRMS, 1D, and 2D NMR spectra of the new compounds are available as Supporting Information.

  • Supporting Information
 

  • References

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