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Senologie - Zeitschrift für Mammadiagnostik und -therapie 2020; 17(02): 94-104
DOI: 10.1055/a-1157-3629
Wissenschaftliche Arbeit

Update Mammakarzinom 2020 Teil 1 – frühes Mammakarzinom: Konsolidierung des Wissens über bekannte Therapien

Update Breast Cancer 2020 Part 1 – Early Breast Cancer: Consolidation of Knowledge About Known Therapies
Andreas Schneeweiss
1   National Center for Tumor Diseases, Division Gynecologic Oncology, University Hospital and German Cancer Research Center, Heidelberg
,
Andreas D. Hartkopf
2   Department of Obstetrics and Gynecology, University of Tübingen, Tübingen
,
Volkmar Müller
3   Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg
,
Achim Wöckel
4   Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg
,
Michael P. Lux
5   Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten
,
Wolfgang Janni
6   Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm
,
Johannes Ettl
7   Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich
,
Erik Belleville
8   ClinSol GmbH & Co KG, Würzburg
,
Jens Huober
6   Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm
,
Marc Thill
10   Agaplesion Markus Krankenhaus, Frauenklinik, Frankfurt
,
Peter A. Fasching
11   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen
,
Hans-Christian Kolberg
12   Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop
,
Patrik Pöschke
11   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen
,
Manfred Welslau
13   Onkologie Aschaffenburg, Aschaffenburg
,
Friedrich Overkamp
14   OncoConsult Overkamp GmbH, Berlin
,
Hans Tesch
15   Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt
,
Tanja N. Fehm
16   Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf
,
Diana Lüftner
17   Charité University Hospital, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin
,
Florian Schütz
9   Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg
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Zusammenfassung

In dieser Übersichtsarbeit werden die neuesten Entwicklungen in der Prävention und in der Behandlung des frühen Mammakarzinoms dargestellt. Mit großen epidemiologischen Studien zu genetischen und nicht genetischen Risikofaktoren wird das Brustkrebsrisiko immer besser beschreibbar. Durch neue Analysen konnte sowohl die Evidenz für hoch penetrante Gene als auch für niedrig penetrante Gene verbessert werden. Neue Daten zu Denosumab und Atezolizumab liegen in der Neoadjuvanz vor, genauso wie eine gepoolte Auswertung zahlreicher Studien zu Capecitabin in der kurativen Situation. Ebenso gibt es eine Aktualisierung der Gesamtüberlebensdaten von Pertuzumab in der Adjuvanz mit einer längeren Nachbeobachtungszeit. Letztlich hält die digitale Medizin stetigen Einzug in die Wissenschaft. Eine kürzlich durchgeführte Studie zur automatisierten Brustkrebserkennung mittels künstlicher Intelligenz schafft die Grundlagen für eine künftige Überprüfung in klinischen Studien.

Abstract

This review is intended to present the latest developments in the prevention and treatment of early breast cancer. The risk of breast cancer can be increasingly better characterised with large epidemiological studies on genetic and non-genetic risk factors. Through new analyses, the evidence for high-penetrance genes as well as for low-penetrance genes was able to be improved. New data on denosumab and atezolizumab are available in the neoadjuvant situation as is a pooled appraisal of numerous studies on capecitabine in the curative situation. There is also an update to the overall survival data of pertuzumab in the adjuvant situation with a longer follow-up observation period. Finally, digital medicine is steadily finding its way into science. A recently conducted study on automated breast cancer detection using artificial intelligence establishes the basis for a future review in clinical studies.

Schlüsselwörter

frühes Mammakarzinom - Prävention - Therapie - Prognose - Immuntherapie - digitale Medizin

Key words

early breast cancer - prevention - therapy - prognosis - immune therapy - digital medicine


Publication History

Article published online:
25 June 2020

© Georg Thieme Verlag KG
Stuttgart · New York

 

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