Increased risk of ischemic heart disease and diabetes in inflammatory bowel disease

Zhihui Li; Lili Qiao; Xiaojing Yun; Fangjuan Du; Shilei Xing; Maowu Yang

doi:10.1055/a-1283-6966

Zeitschrift für Gastroenterologie, Table of Contents

Z Gastroenterol 2021; 59(02): 117-124
DOI: 10.1055/a-1283-6966

Originalarbeit

Increased risk of ischemic heart disease and diabetes in inflammatory bowel disease

Erhöhtes Risiko für ischämische Herzerkrankungen und Diabetes bei entzündlichen Darmerkrankungen

Zhihui Li

Department of Gastroenterology, The Second People’s Hospital of Liaocheng, the Second Hospital of Liaocheng affiliated to Shandong First Medical University, Liaocheng, Shandong Province, China

,

Lili Qiao

Department of Gastroenterology, The Second People’s Hospital of Liaocheng, the Second Hospital of Liaocheng affiliated to Shandong First Medical University, Liaocheng, Shandong Province, China

,

Xiaojing Yun

Department of Gastroenterology, The Second People’s Hospital of Liaocheng, the Second Hospital of Liaocheng affiliated to Shandong First Medical University, Liaocheng, Shandong Province, China

,

Fangjuan Du

Department of Gastroenterology, The Second People’s Hospital of Liaocheng, the Second Hospital of Liaocheng affiliated to Shandong First Medical University, Liaocheng, Shandong Province, China

,

Shilei Xing

Department of Gastroenterology, The Second People’s Hospital of Liaocheng, the Second Hospital of Liaocheng affiliated to Shandong First Medical University, Liaocheng, Shandong Province, China

,

Maowu Yang

Department of Gastroenterology, The Second People’s Hospital of Liaocheng, the Second Hospital of Liaocheng affiliated to Shandong First Medical University, Liaocheng, Shandong Province, China

› Author Affiliations

Abstract

Background Previous studies showed inconsistent results regarding associations between inflammatory bowel disease (IBD) and risk of ischemic heart disease (IHD) and diabetes. The present study aimed to make a meta-analysis to assess the risk of IHD and diabetes in IBD.

Methods We searched for articles published before February 2020 in the databases as follows: PubMed, Web of Science, Medline, EMBASE, and Google Scholar. We computed odds ratio (OR) or relative risk (RR) and 95 % confidence intervals (CI) regarding the association between IBD and risk of IHD or diabetes by using STATA 13.0 software.

Results The present meta-analysis showed that IBD was associated with higher risk of IHD (OR/RR = 1.26, 95 % CI 1.20 to 1.32, I2 = 88.3 %, p < 0.0001). Additionally, both ulcerative colitis (UC) and Crohn’s disease (CD) were associated with higher risk of IHD (UC: OR/RR = 1.19, 95 % CI 1.13 to 1.26, I2 = 65.6 %, p = 0.001; CD: OR/RR = 1.33, 95 % CI 1.17 to 1.51, I2 = 89.5 %, p < 0.0001). The study showed that IBD was associated with elevated risk of diabetes (OR/RR = 1.26, 95 % CI 1.03 to 1.53, I2 = 92.1 %, I2 = 92.1 %, p < 0.0001). Additionally, both UC and CD were associated with higher risk of diabetes (UC: OR/RR = 1.33, 95 % CI 1.03 to 1.71, I2 = 93.8 %, p < 0.0001; CD: OR/RR = 1.39, 95 % CI 1.10 to 1.76, I2 = 76.7 %, p = 0.002).

Conclusion In conclusion, patients with IBD are at increased risk of IHD and diabetes. Thus, regular monitoring of biomarkers of IHD and blood glucose levels should be considered for the early detection of IHD and diabetes in IBD patients.

Zusammenfassung

Hintergrund Frühere Studien zeigten inkonsistente Ergebnisse hinsichtlich der Zusammenhänge zwischen entzündlichen Darmerkrankungen (IBD) und dem Risiko einer ischämischen Herzerkrankung (IHD) und Diabetes. Die vorliegende Studie zielte darauf ab, eine Metaanalyse durchzuführen, um das Risiko von IHD und Diabetes bei IBD zu bewerten.

Methoden Wir haben nach Artikeln gesucht, die vor Februar 2020 in den Datenbanken wie folgt veröffentlicht wurden: PubMed, Web of Science, Medline, EMBASE und Google Scholar. Wir haben das Odds Ratio (OR) oder das relative Risiko (RR) und 95 %-Konfidenzintervalle (CI) in Bezug auf den Zusammenhang zwischen IBD und IHD- oder Diabetes-Risiken mithilfe der STATA 13.0-Software berechnet.

Ergebnisse Die vorliegende Metaanalyse zeigte, dass IBD mit einem höheren Risiko für IHD assoziiert war (OR/RR = 1,26, 95 % CI 1,20 bis 1,32, I2 = 88,3 %, p < 0,0001). Zusätzlich waren sowohl Colitis ulcerosa (UC) als auch Morbus Crohn (CD) mit einem höheren Risiko für IHD assoziiert (UC: OR/RR = 1,19, 95 % CI 1,13 bis 1,26, I2 = 65,6 %, p = 0,001; CD: OR/RR = 1,33, 95 % CI 1,17 bis 1,51, I2 = 89,5 %, p < 0,0001). Die Studie zeigte, dass IBD mit einem erhöhten Diabetes-Risiko assoziiert war (OR/RR = 1,26, 95 % CI 1,03 bis 1,53, I2 = 92,1 %, I2 = 92,1 %, p < 0,0001). Zusätzlich waren sowohl UC als auch CD mit einem höheren Diabetesrisiko assoziiert (UC: OR/RR = 1,33, 95 % CI 1,03 bis 1,71, I2 = 93,8 %, p < 0,0001; CD: OR/RR = 1,39, 95 % CI 1,10 bis 1,76, I2 = 76,7 %, p = 0,002).

Schlussfolgerung Zusammenfassend lässt sich sagen, dass Patienten mit IBD ein erhöhtes Risiko für IHD und Diabetes haben. Daher sollte eine regelmäßige Überwachung der Biomarker für IHD und Blutzuckerspiegel in Betracht gezogen werden, um IHD und Diabetes bei IBD-Patienten frühzeitig zu erkennen.

Key words

inflammatory bowel disease - ischemic heart disease - diabetes - meta-analysis

Schlüsselwörter

entzündliche Darmerkrankungen - ischämische Herzerkrankungen - Diabetes - Metaanalyse

Full Text

References

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Supplementary Material

Supplementary Material