Recreational Dance Practice Modulates Lymphocyte Profile and Function in Diabetic Women

Maria Elizabeth Pereira Passos; Leandro Borges; Laiane Cristina dos Santos-Oliveira; Amanda Lins Alecrim-Zeza; Tiago Bertola Lobato; Heloisa Helena de Oliveira; Cesar Miguel Momesso Santos; Vinicius Leonardo Sousa Diniz; Patrícia Nancy Iser-Bem; Richelieau Manoel; Gilson Masahiro Murata; Sandro Massao Hirabara; Rui Curi; Tania Cristina Pithon-Curi; Elaine Hatanaka; Renata Gorjao

doi:10.1055/a-1309-2037

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2021; 42(08): 749-759
DOI: 10.1055/a-1309-2037

Clinical Sciences

Recreational Dance Practice Modulates Lymphocyte Profile and Function in Diabetic Women

Maria Elizabeth Pereira Passos

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

²Department of Laboratory Medicine, Universidade Federal de São Paulo, Sao Paulo, Brazil

,

Leandro Borges

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Laiane Cristina dos Santos-Oliveira

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Amanda Lins Alecrim-Zeza

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Tiago Bertola Lobato

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Heloisa Helena de Oliveira

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Cesar Miguel Momesso Santos

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Vinicius Leonardo Sousa Diniz

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Patrícia Nancy Iser-Bem

,

Richelieau Manoel

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Gilson Masahiro Murata

³Department of Medical Clinic, Sao Paulo University Faculty of Medicine, Sao Paulo, Brazil

,

Sandro Massao Hirabara

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Rui Curi

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

⁴Butantan Institute, Sao Paulo, Brazil

,

Tania Cristina Pithon-Curi

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Elaine Hatanaka

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

,

Renata Gorjao

¹Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

› Institutsangaben

Abstract

This study aimed to investigate the impact of a 16-week dance-based aerobic exercise program on lymphocyte function in healthy and type 2 diabetes mellitus (T2DM) women. We enrolled 23 women: 11 with T2DM and 12 non-diabetic controls. Initially, we performed anthropometry and body composition measurements, afterwards, plasma levels of C-reactive protein, lipids, and glucose were determined. We used flow cytometry to measure the CD25 and CD28 expression in circulating lymphocytes, T-regulatory (Treg) cell percentage, lymphocyte proliferation, and cytokines released by cultured lymphocytes. The T2DM group had a lower proportion of CD28+ cells and a higher percentage of Treg lymphocytes and proliferative capacity at the baseline compared with the control group. After 16 weeks of the program, differences in lymphocytes between the T2DM and the control groups disappeared. The dance program promoted IL-10 increase in both groups. We found decreased IL-4, IL-2, and IL-6 secretion in lymphocytes from the control group and increased IL-17 secretion and IL-10/IL-17 ratio in the T2DM group after the program. The program promoted marked changes in lymphocytes in diabetic women, leading to a balance between the different profiles.

Key words

T-regulatory cells - moderate physical exercise - interleukin-10

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Referenzen

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