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Drug Res (Stuttg) 2021; 71(04): 180-192
DOI: 10.1055/a-1320-0479
Review

Recent Therapeutic Interventions of Fenugreek Seed: A Mechanistic Approach

Sahar Idris
1   Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India
,
Anuradha Mishra
1   Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India
,
Md Khushtar
1   Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India
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Abstract

Fenugreek seeds have widespread relations with Ayurveda, Unani, and Arabic medicine. The seeds were useful for the treatment and prevention of different ailments. Fenugreek (Trigonella foenum-graecum) or methi is from the Leguminosae family and are primarily known for its anti-diabetic and hypocholesterolemic activities. The germinated fenugreek seeds were used in the treatment of E.coli infection in Germany and France. The important phytoconstituents responsible for such medicinal applications are saponins, polyunsaturated fatty acids, galactomannans, trigonelline, and 4-hydroxy isoleucine. Flavonoids, apigenin 6,8-di-C-glucoside, apigenin-6-C-glucosyl-8-C-galactoside, 6-Cgalactosyl- 8-C-arabinoside are the chief ingredients of fenugreek seeds; responsible for reducing blood glucose while given to diabetic rats, whereas important flavones are epigenin, luteolin and vitexin. The other major bioactive components in fenugreek seeds are polyphenols like rhaponticin and isovitexin. Fenugreek seeds contain phosphorus and are categorized into different classes such as inorganic phosphorus, phospholipids, phytates, phosphor-proteins, and nucleic acid. Germinated seeds profusely filled with amino acids with amino acids, proteins, ascorbic acid, sugars. Further, this review shares information about the recent therapeutic intervention not covered earlier; on in vivo and in vitro and some clinical applications against certain interesting ailments other than older applications. This review includes certain nano delivery systems of Fenugreek seeds and their medicinal application.

Key words

fenugreek - phytoconstituent - saponin - flavonoids - nanodelivery


Publication History

Received: 04 September 2020

Accepted: 16 November 2020

Article published online:
30 December 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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