Risikoprofil rheumatologische Basistherapie – ein Update aus dem RABBIT-Register

Was ist neu?

TNF-alpha-Inhibitoren Unter TNF-alpha-Inhibitoren (TNFi) zeigt sich kein Hinweis für ein insgesamt erhöhtes Malignomrisiko. Venöse Thromboembolien treten unter TNFi seltener auf als unter konventionellen synthetischen Disease-modifying antirheumatic Drugs (csDMARDs).

IL-6-Rezeptor-Inhibitoren Die Inzidenz von Perforationen des unteren Darmtrakts ist unter einer Behandlung mit Tocilizumab erhöht und präsentiert sich mit untypischer Symptomatik. Es gibt keinen Hinweis auf vermehrte Fazialisparesen unter Tocilizumab.

JAK-Inhibitoren Januskinase-Inhibitoren erhöhen das Risiko für das Auftreten eines Herpes zoster.

Biosimilars Originalprodukte und Biosimilars zeigen ein vergleichbares Sicherheits- und Wirksamkeitsprofil.

Abstract

This article provides an overview of current results from the German biologics register RABBIT on the safety of biologic and targeted synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis. Collaborative data from the European biologics registries show no evidence for an overall increased risk of malignancy with TNF inhibitors. Venous thromboembolism occurs less frequently under TNF inhibitors than under conventional synthetic DMARDs. Regarding interleukin-6 inhibitors, the incidence of lower intestinal tract perforations is increased with tocilizumab and presents with atypical symptoms. There is no evidence of increased facial paresis with tocilizumab. Janus kinase inhibitors increase the risk for the occurrence of herpes zoster. New data on biosimilars suggest that they can be used with a comparable safety profile to originator drugs.

Schlüsselwörter

rheumatoide Arthritis - Biologika - DMARDs - Sicherheit

Key words

rheumatoid arthritis - biologics - dmards - safety

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