Konfokale Laser-Endomikroskopie des Kopf-Hals-Plattenepithelkarzinoms: eine systematische Übersicht

Zusammenfassung

Hintergrund Die konfokale Laser-Endomikroskopie (CLE) bietet mit einer bis zu 1000-fachen Vergrößerungsleistung die Möglichkeit, Interzellularräume in vivo zu erkennen. Die CLE hat sich in verschiedensten Fachbereichen bereits etabliert. Dieser Artikel gibt einen Überblick über die aktuelle Studienlage der CLE in der Diagnostik des Plattenepithelkarzinoms des Kopf-Hals-Bereichs.

Material und Methoden Systematische Literaturrecherche in folgenden Online-Datenbanken: PubMed, MEDLINE, Thompson Reuters Web of Science, SPIE nach den Suchbegriffen: confocal laser endomicroscopy, CLE, endomicroscopy, head and neck, larynx. Bewertung der wissenschaftlichen Relevanz der Arbeiten nach festgelegten Kriterien.

Ergebnisse Es wurden Arbeiten in Bezug auf die klinische Anwendung, die klinische Befunderhebung und die computergestützte Datenauswertung analysiert.

Schlussfolgerungen In Zusammenschau der aktuell publizierten Ergebnisse verspricht die CLE ein großes Potenzial, die Diagnostik maligner Schleimhautveränderungen im Bereich des oberen Aerodigestivtrakts zu verbessern.

Abstract

Objective Confocal laser endomicroscopy (CLE), with a magnification of up to 1000 ×, offers the possibility to visualize intercellular spaces in vivo. CLE has already established itself in different disciplines. This article gives an overview of the current research on CLE in the diagnosis of the head and neck squamous cell carcinoma.

Material and methods Systematic bibliographic research in the following online databases: PubMed, MEDLINE, Thompson Reuters Web of Science, SPIE using the following keywords: confocal laser endomicroscopy, CLE, endomicroscopy, head and neck, larynx. Evaluation of the scientific relevance according to defined criteria.

Results All studies were analyzed concerning the clinical application, clinical findings, and computer-aided data processing.

Conclusions The recently published data suggest that CLE has a high potential to improve the diagnosis of malignant mucosal lesions in the upper aerodigestive tract.

Schlüsselwörter

konfokale Laser-Endomikroskopie - CLE - Kopf-Hals-Malignom - Larynxkarzinom - Bildanalyse

Key words

confocal laser endomicroscopy - CLE - head and neck malignancy - laryngeal carcinoma - image analysis

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