Abstract
Visible-light photoredox catalysis has recently emerged as a powerful tool for the development of new and valuable chemical transformations under mild conditions. Visible-light promoted enantioselective radical transformations of imines and iminium intermediates provide new opportunities for the asymmetric synthesis of amines and the asymmetric β-functionalization of unsaturated carbonyl compounds. In this review, recent advances on the catalytic asymmetric radical functionalization of imines and iminium intermediates are summarized.
1 Introduction
2 Enantioselective Radical Functionalization of Imines
2.1 Asymmetric Reduction
2.2 Asymmetric Cyclization
2.3 Asymmetric Addition
2.4 Asymmetric Radical–Radical Coupling
3 Enantioselective Radical Functionalization of Iminium Ions
3.1 Asymmetric Radical Alkylation
3.2 Asymmetric Radical Acylation
4 Conclusion
Key words
asymmetric catalysis - photocatalysis - radicals - imines - iminium ions
