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Synthesis 2021; 53(10): 1821-1827
DOI: 10.1055/a-1344-2126
DOI: 10.1055/a-1344-2126
paper
Construction of α-Alkylated Amines by Iridium Complex-Catalyzed One-Step Transfer Hydrogenation of C=C and C=N Bonds
The authors thank the National Natural Science Foundation of China (21962004, 21562004), Jiangxi Provincial Department of Science and Technology (20192BAB203004), the Emergency Research Project for Gannan Medical University (YJ202027), and the Fundamental Research Funds for Gannan Medical University (QD201810) for financial support.
Abstract
Hydrogenation of C=C bond and reductive amination are important transformations utilized in chemistry. An environmentally friendly, efficient, and facile one-pot transfer hydrogenation of C=C bond of enones and reductive amination of C=N bond of imines are reported using iridium complex as catalysts and formic acid as hydrogen source in aqueous medium. In this catalytic system, a wide range of α-alkylated amines were obtained in excellent yields by one-pot transfer hydrogenation of C=C bond and reductive amination. The practical application of this protocol is characterized by gram-scale transformation.
Supporting Information
- Supporting information for this article is available online at https://doi.org/a-1344-2126.
- Supporting Information
Publication History
Received: 17 November 2020
Accepted after revision: 30 December 2020
Accepted Manuscript online:
30 December 2020
Article published online:
09 February 2021
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