Thrombocytopenia-Associated Multi-Organ Failure Due To Diabetic Ketoacidosis and Viral Infection: A Case Report

Introduction

Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes mellitus (DM) and associated with hyperglycemia, ketosis, and metabolic acidosis. DKA and its complications are the most common cause of hospitalization, morbidity and mortality in children with type 1 DM (Wolfsdorf JI et al., Pediatr Diabetes 2018; 27: 155–177).

New-onset thrombocytopenia has been established as an important independent risk factor for multi-organ failure and mortality in critically ill patients. Thrombocytopenia-associated multiple organ failure (TAMOF) is a thrombotic microangiopathic syndrome that can be defined by a spectrum of pathology that includes thrombotic thrombocytopenic purpura, disseminated intravascular coagulation and secondary thrombotic microangiopathy (Nguyen TC et al., Crit Care. 2006;10: 235).

Herein, we report the development of TAMOF in the patient who presented with diabetic ketoacidosis triggered by parainfluenza virus infection.

Publication History

Article published online:
18 February 2021