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DOI: 10.1055/a-1377-8767
Current Challenges Facing Cornea Banks
Artikel in mehreren Sprachen: English | deutsch![](https://www.thieme-connect.de/media/klimo/202106/lookinside/thumbnails/10-1055-a-1377-8767_kl2363_en-1.jpg)
Abstract
Cornea transplants are tissue transplants and, as such, must be distinguished from organ transplants (e.g. heart or kidney transplants). However, tissue transplants can only be performed if there are enough donors available to attend to patients in need. Unfortunately, there are too few organ and tissue donors in Germany. All steps involved in processing donor tissues must be performed in accordance with the highest quality standards. All tasks and measures are aimed at improving patient care in the surgical units that are to be supplied. Cornea banks are subject to complex requirements, whose implementation is essential in terms of both infrastructure and personnel. The analysis and identification of essential topics reveal central fields of action that are decisive for implementing the challenges facing cornea banks. Questions of employee qualification, strategic questions due to new transplantation techniques, and changes in the societal perception of organ and tissue donation require the development of strategies that should have a holistic and sustainable effect.
Publikationsverlauf
Eingereicht: 27. Januar 2021
Angenommen: 15. März 2021
Artikel online veröffentlicht:
22. Juni 2021
© 2021. Thieme. All rights reserved.
Georg Thieme Verlag KG
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References/Literatur
- 1 Payne JW. New directions in eye banking. Trans Am Ophthalmol Soc 1980; 78: 983-1026
- 2 Summerlin WT, Miller GE, Harris JE. et al. The organ-cultured cornea: an in vitro study. Invest Ophthalmol 1973; 12: 176-178
- 3 Pels E. Organ culture: the method of choice for preservation of human donor corneas. Br J Ophthalmol 1997; 81: 523-525
- 4 Deutsches Ärzteblatt. In Deutschland fehlen Hornhautspender für Transplantationen. Accessed January 27, 2021 at: https://www.aerzteblatt.de/nachrichten/102836/In-Deutschland-fehlen-Hornhautspender-fuer-Transplantationen
- 5 Melles GR. Posterior lamellar keratoplasty DLEK to DSEK to DMEK. Cornea 2006; 25: 879-881 DOI: 10.1097/01.ico.0000243962.60392.4f.
- 6 Flockerzi E, Maier P, Böhringer D. et al. Trends in Corneal transplantation from 2001 to 2016 in Germany: A Report of the DOG-Section Cornea and its Keratoplasty Registry. Am J Ophthalmol 2018; 188: 91-98 DOI: 10.1016/j.ajo.2018.01.018.
- 7 Price MO, Giebel AW, Fairchild KM. et al. Descemetʼs membrane endothelial keratoplasty: prospective multicenter study of visual and refractive outcomes and endothelial survival. Ophthalmology 2009; 116: 2361-2368 DOI: 10.1016/j.ophtha.2009.07.010.
- 8 Schlögl A, Tourtas T, Kruse FE. et al. Long-term Clinical Outcome After Descemet Membrane Endothelial Keratoplasty. Am J Ophthalmol 2016; 169: 218-226 DOI: 10.1016/j.ajo.2016.07.002.
- 9 Zhu L, Zha Y, Cai J. et al. Descemet stripping automated endothelial keratoplasty versus Descemet membrane endothelial keratoplasty: a meta-analysis. Int Ophthalmol 2018; 38: 897-905 DOI: 10.1007/s10792-017-0533-3.
- 10 European Commission, Enterprise and Industry Directorate-General. EudraLex: the Rules Governing Medicinal Products in the European Union. Volume 4. EU Guidelines of Good Manufacturing Practice for Human and Veterinary Use. Brussels, 25 November 2008. Accessed January 27, 2021 at: http://www.ec.europa.eu/health/sites/health/files/files/eudralex/vol-4/2008_11_25_gmp-an1_en.pdf
- 11 Breksler A, Inel B, Loimayr C. et al. GMP-konforme Herstellung von DMEK-Transplantaten in einer Gewebebank. Spektrum Augenheilkd 2014; 28: 70
- 12 Lie JT, Birbal R, Ham L. et al. Donor tissue preparation for Descemet membrane endothelial keratoplasty. J Cataract Refract Surg 2008; 34: 1578-1583 DOI: 10.1016/j.jcrs.2008.05.036.
- 13 Menzel-Severing J, Walter P, Plum W. et al. Assessment of Corneal Endothelium during Continued Organ Culture of Pre-Stripped Human Donor Tissue for DMEK Surgery. Curr Eye Res 2018; 43: 1439-1444 DOI: 10.1080/02713683.2018.1501805.
- 14 Salla S, Kruse FE, Walter P. et al. Supplementation of organ-culture medium with dextran is not required in pre-stripped human donor tissue for DMEK surgery. Cell Tissue Bank 2019; 20: 193-200 DOI: 10.1007/s10561-019-09757-8.
- 15 Tausif HN, Johnson L, Titus M. et al. Corneal donor tissue preparation for Descemetʼs membrane endothelial keratoplasty. J Vis Exp 2014; (91) 51919 DOI: 10.3791/51919.
- 16 Bundesärztekammer – Wissenschaftlicher Beirat. Richtlinie zum Führen einer Hornhautbank. Dtsch Arztebl 2000; 97: A2122-A2124
- 17 Bundesärztekammer. Richtlinie zur Gewinnung von Spenderhornhäuten und zum Führen einer Augenhornhautbank, Erste Fortschreibung. Dtsch Arztebl 2018; 2018: A1-A18 DOI: 10.3238/arztebl.2018.rl_augenhornhautbank_02.
- 18 Paul-Ehrlich-Institut. Gewebezubereitungen. Accessed November 29, 2020 at: https://www.pei.de/DE/arzneimittel/gewebezubereitungen/augenhornhaut-cornea/cornea.-liste
- 19 von Auer F. Das Gewebegesetz – Hintergründe und Konsequenzen. Transfus Med Hemother 2008; 35: 407-413 DOI: 10.1159/000167000.
- 20 Bundeszentrale für Gesundheitliche Aufklärung (BzgA). Wissen, Einstellung und Verhalten zur Organ- und Gewebespende. Repräsentativbefragung 2018. Accessed January 27, 2021 at: https://www.organspende-info.de/zahlen-und-fakten/einstellungen-und-wissen.html
- 21 Caille-Brillet AL, Zimmering R, Thaiss HM. Bericht zur Repräsentativstudie 2018: Wissen, Einstellung und Verhalten der Allgemeinbevölkerung zur Organ- und Gewebespende. BZgA-Forschungsbericht. Köln: Bundeszentrale für gesundheitliche Aufklärung (BZgA); 2019
- 22 Rothe M. Was Juden und Muslime zur Organspende sagen (11.11.2011). Accessed January 27, 2021 at: https://www.evangelisch.de/inhalte/106816/11-11-2011/was-juden-und-muslime-zur-organspende-sagen
- 23 Stiel S, Walter P, Salla S. Evaluation eines Kommunikationstrainings für Mitarbeitende in Hornhautbanken. Der Augenspiegel 2019; 2019: 36-39
- 24 Cassel M. ISO 9001 Qualitätsmanagement prozessorientiert umsetzen. München, Wien: Carl Hanser; 2007
- 25 Hermel M, Monhof C, Steinfeld S. et al. The Role of Specifically Tailored Communication Training Among Factors Influencing Consent for Cornea Donation Requested Via Telephone. Transplantation 2015; 99: 2223-2229
- 26 Fuest M, Boor P, Knuechel R. et al. Postmortem conjunctival and nasopharyngeal swabs in SARS-CoV-2 infected and uninfected patients. Acta Ophthalmol 2020; DOI: 10.1111/aos.14559.
- 27 Trigaux C, Salla S, Schroeter J. et al. SARS-CoV-2: Impact on Risk Assessment and Countermeasures in German Eye Banks. Curr Eye Res 2020; DOI: 10.1080/02713683.2020.1828487.
- 28 Moll A, Khayati S. Hrsg. Excellence-Handbuch. Grundlagen und Anwendung des EFQM Modells 2020. Kissing: WEKA MEDIA; 2019