Dtsch Med Wochenschr 2021; 146(15): 1009-1015
DOI: 10.1055/a-1388-9889
Übersicht

Schmerzmedikamente bei Nierenpatienten

Analgesic Drug Therapy in Kidney Patients
Peter Steffen
,
Frieder Keller
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Für die Schmerztherapie bei Nierenkranken und Dialysepatienten sind besondere Kenntnisse nötig. Denn zunächst einmal können bestimmte Analgetika die Nieren schädigen. Hinzu kommt, dass die Dosierung von Koanalgetika wie Antikonvulsiva, Antidepressiva und Antipsychotika i. d. R. an die Nierenfunktion angepasst werden muss. Außerdem besteht bei einer Morphintherapie durch die Kumulationskinetik ein erhöhtes Risiko für eine Atemdepression.

Abstract

Analgesic drug therapy in kidney patients needs special expertise. Patients with kidney disease frequently have pain and they have chronic pain more than others. Some analgesic drugs have a nephrotoxic potential and co-analgesics such as anticonvulsive, antidepressive and antipsychotic drugs need a dose adjustment to kindey function. When treating kidney patients with morphine, the accumulation kinetics of the M6 glucuronide must be observed. Otherwise, the risk increases for respiratory depression.

Schlüsselwörter

Schmerztherapie - Nierenerkrankung - Dosisanpassung - Morphin - Dialyse

Key words

analgesic drugs - kidney disease - dose adjustment - morphine - dialysis


Publication History

Article published online:
03 August 2021

© 2021. Thieme. All rights reserved.

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