Update 2021: Vitamin C und Zink bei COVID-19

Zusammenfassung

Aktuelle Studien zeigen einen deutlichen Benefit von Vitamin C bei COVID-19. Signifikante Verbesserungen gab es bei Sauerstoffversorgung, Reduktion des Zytokinsturms, Mortalitätsrisko, Heilungsrate und Verweildauer im Krankenhaus. Bei der supportiven Therapie mit Vitamin C erzielen Infusionen höhere Wirkspiegel im Blut als die orale Gabe, bei der u. a. genetisch bedingte Resorptionsunterschiede die Wirkung beeinflussen.

Schlüsselwörter

COVID-19 - Vitamin C - Zink - Sauerstoffversorgung - Zytokinsturm - Mortalitätsrisiko - Genesungsrate

• Referenzen

• 1 Gao D. et al. The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study. Aging (Albany NY) 2021; 13
• 2 Zhang J. et al. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann Intensive Care 2021; 11 (01) : 5
• 3 Kumari P. et al. The Role of Vitamin C as Adjuvant Therapy in COVID-19. Cureus 2020; 12 (11) : e11779
• 4 Thomas S. et al. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open 2021; 4 (02) : e210369
• 5 Chiscano-Camon L. et al. Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome. Crit Care 2020; 24 (01) : 522
• 6 Carr AC. et al. Patients with Community Acquired Pneumonia Exhibit Depleted Vitamin C Status and Elevated Oxidative Stress. Nutrients 2020; 12 (05) : 1318
• 7 Xing Y. et al. Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high-performance liquid chromatography-tandem mass spectrometry finding. J Pharm Biomed Anal 2021; 196: 113927
• 8 Pincemail J. et al. Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study. Antioxidants (Basel). 2021 10. (2)
• 9 Arvinte C, Singh M, Marik PE. Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically lll COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study. Med Drug Discov 2020; 8: 100064
• 10 Hemila H. Therapeutic 8 g / day of vitamin C increases recovery rate from SARS-CoV-2 infection by 71 % (P = 0.036) based on the randomized trial by Thomas et al. (2021). Comment on Thomas et al. 2021 Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. 2021 https://pubpeer.com/publications/6DFC3BD2E1DAA79A9BBD1DAF5D9BB4#1 ; Stand: 25. 02.2021
• 11 Kuiper C, Vissers MC, Hicks KO. Pharmacokinetic modeling of ascorbate diffusion through normal and tumor tissue. Free Radic Biol Med 2014; 77: 340-352
• 12 Patterson T, Isales CM, Fulzele S. Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection. Aging Dis 2021; 12 (01) : 14-26