kleintier konkret, Table of Contents kleintier konkret 2021; 24(03): 38-47DOI: 10.1055/a-1407-1150 Innere Medizin Exokrine Pankreasinsuffizienz beim Hund und bei der Katze Florian Wall , Kimberly Bartels , Susanne Mangelsdorf-Ziera Recommend Article Abstract Buy Article All articles of this category Die exokrine Pankreasinsuffizienz von Hund und Katze kann sowohl diagnostisch als auch therapeutisch zur Herausforderung werden. Der vorliegende Beitrag gibt einen aktuellen Überblick. Full Text References Literatur 1 Ettinger SJ, Feldmann EC. Textbook of Veterinary Internal Medicine: Diseases of the Dog and the Cat. St. Louis: Elsevier; 2017 2 Lindkvist B. Diagnosis and treatment of pancreatic exocrine insufficiency. World J Gastroenterol 2013; 19 (42) 7258-7266 3 Xenoulis PG, Zoran DL, Fosgate GT. et al. Feline exocrine pancreatic insufficiency: a retrospective study of 150 cases. J Vet Intern Med 2016; 30 (06) 1790-1797 4 Westermarck E, Wiberg M. Exocrine pancreatic insufficiency in the dog: historical background, diagnosis and treatment. Top Companion Anim Med 2012; 27 (03) 96-103 5 Westermarck E, Saari SAM, Wiberg ME. Heritability of exocrine pancreatic insufficiency in German Shepherd dogs. J Vet Intern Med 2010; 24: 450-452 6 Westermarck E, Wiberg M. Exocrine pancreatic insufficiency in dogs. Vet Clin North Am Small Anim Pract 2003; 33 (05) 1165-1179 7 German AJ. Exocrine pancreatic insufficiency in the dog: breed associations, nutritional considerations, and long-term outcome. Top Companion Anim Med 2012; 27 (03) 104-108 8 Alvarez MS, Herreia-Bustillo V, Font-Utset A. et al. Juvenile diabetes mellitus and concurrent exocrine pancreatic insufficiency in a Labrador Retriever: long-term management. J Am Anim Hosp Assoc 2015; 51 (06) 419-423 9 Brenner K, Harkin KR, Andrews GA. et al. Juvenile pancreatic atrophy in Greyhounds: 12 cases (1995–2000). J Vet Intern Med 2009; 23 (01) 67-71 10 Wiberg ME, Saari SA, Westermarck E. Exocrine pancreatic atrophy in German shepherd dogs and rough-coated collies: an end result of lymphocytic pancreatitis. Vet Pathol 1999; 36 (06) 530-541 11 Westermarck E. The hereditary nature of canine pancreatic degenerative atrophy in the German shepherd dog. Acta Vet Scand 1980; 21 (03) 389-394 12 Moeller EM, Steiner JM, Clark LA. et al. Inheritance of pancreatic acinar atrophy in German shepherd dogs. Am J Vet Res 2002; 63 (10) 1429-1434 13 Tsai KL, Noorai RE, Starr-Moss AN. et al. Genome-wide association studies for multiple diseases of the German shepherd dog. Mamm Genome 2012; 23 (1 – 2): 203-211 14 Batchelor DJ, Noble PJM, Cripps PJ. et al. Breed associations for canine exocrine pancreatic insufficiency. J Vet Intern Med 2007; 21 (02) 207-214 15 Westermarck E, Batt RM, Vaillant C. et al. Sequential study of pancreatic structure and function during development of pancreatic acinar atrophy in dogs and the role of external factors in the development of the disease. Am J Vet Res 1993; 54: 1088-1094 16 Proschowsky HF, Fredholm M. Exocrine pancreatic insufficiency in the Eurasian dog breed: inheritance and exclusion of two candidate genes. Anim Genet 2007; 38 (02) 171-173 17 Clark LA, Cox ML. Current status of genetic studies of exocrine pancreatic insufficiency in dogs. Top Companion Anim Med 2012; 27 (03) 109-112 18 Wiberg ME, Saari SAM, Westermarck E. et al. Cellular and humoral immune responses in atrophic lymphocytic pancreatitis in German shepherd dogs and rough-coated collies. Vet Immunol Immunopathol 2000; 76 (1 – 2): 103-115 19 Wiberg ME, Westermarck E. Subclinical exocrine pancreatic insufficiency in dogs. J Am Vet Med Assoc 2002; 220 (08) 1183-1187 20 Xenoulis PG, Suchodolski JS, Steiner JM. Chronic pancreatitis in dogs and cats. Compend Contin Educ Vet 2008; 30 (03) 166-180 21 Watson PJ. Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dogs. J Small Anim Pract 2003; 44 (07) 306-312 22 Watson PJ. Chronic pancreatitis in dogs. Top Companion Anim Med 2012; 27 (03) 133-139 23 Thompson KA, Parnell NK, Hohenhaus AE. et al. Feline exocrine pancreatic insufficiency: 16 cases (1992–2007). J Feline Med Surg 2009; 11 (12) 935-940 24 Kook PH, Zerbe P, Reusch CE. Exokrine Pankreasinsuffizienz bei der Katze. Schweiz Arch Tierheilkd 2011; 153: 19-25 25 Steiner JM. Exocrine pancreatic insufficiency in the cat. Top Companion Anim Med 2012; 27 (03) 113-116 26 Simpson KW, Batt RM, Jones D. et al. Effects of exocrine pancreatic insufficiency and replacement therapy on bacterial flora in the duodenum of dogs. Am J Vet Res 1990; 51 (02) 203-206 27 Bright JM. Pancreatic adenocarcinoma in a dog with maldigestion syndrome. J Am Vet Med Assoc 1985; 187 (04) 420-421 28 Xenoulis PG, Fradkin JM, Rapp SW. et al. Suspected isolated pancreatic lipase deficiency in a dog. J Vet Intern Med 2007; 21 (05) 1113-1116 29 Viviano KR, Ziglioli V. Suspected isolated pancreatic enzyme deficiencies in dogs. J Vet Intern Med 2013; 27 (03) 558-591 30 Carriere F, Laugier R, Barrowman JA. et al. Gastric and pancreatic lipase levels during a test meal in dogs. Scand J Gastroenterol 1993; 28 (05) 443-454 31 DiMagno EP, Go VL, Summerskill WH. Relations between pancreatic enzyme output and malabsorption in severe pancreatic insufficiency. N Eng J Med 1973; 288 (16) 813-815 32 Honneffer JB, Minamoto Y, Suchodolski JS. Microbiota alterations in acute and chronic gastrointestinal inflammation in cats and dogs. World J Gastroenterol 2014; 20 (44) 16489-16497 33 Westermarck E, Myllys V, Aho M. Effect of treatment on the jejunal and colonic bacterial flora of dogs with exocrine pancreatic insufficiency. Pankreas 1993; 8 (05) 559-562 34 Williams DA, Batt RM, McLean L. Bacterial overgrowth in the duodenum of dogs with exocrine pancreatic insufficiency. J Am Vet Med Assoc 1987; 191 (02) 201-206 35 Blake AB, Guard BC, Honneffer JB. et al. Altered microbiota, fecal lactate and fecal bile acids in dogs with gastrointestinal disease. PloS One 2019; 14 (10) e0224454 36 Isaiah A, Parambeth JC, Steiner JM. et al. The fecal microbiome of dogs with exocrine pancreatic insufficiency. Anaerobe 2017; 45: 50-58 37 Soetart N, Rochel D, Drut A. Serum cobalamin and folate as prognostic factors in canine exocrine pancreatic insufficiency: An observational cohort study of 299 dogs. Vet J 2019; 243: 15-20 38 Simpson KW, Morton DB, Batt RM. Effect of exocrine pancreatic insufficiency on cobalamin absorption in dogs. Am J Vet Res 1989; 50 (08) 1233-1236 39 Batchelor DJ, Noble PJM, Taylor RH. et al. Prognostic factors in canine exocrine pancreatic insufficiency: prolonged survival is likely if clinical remission is achieved. J Vet Intern Med 2007; 21 (01) 54-60 40 Barko PC, Williams DA. Serum concentrations of lipid-soluble vitamins in dogs with exocrine pancreatic insufficiency treated with pancreatic enzymes. J Vet Intern Med 2018; 32 (05) 1600-1608 41 Perry LA, Williams DA, Pidgeon GL. et al. Exocrine pancreatic insufficiency with associated coagulopathy in a cat. J Am Hosp Assoc 1991; 27: 109-114 42 Adamama-Moraitou KK, Rallis TS, Papazoglou LG. et al. Liver biochemical and histopathological findings in dogs with experimentally induced exocrine pancreatic insufficiency. Can J Vet Res 2004; 68 (01) 56-61 43 Grützner N, Cranford SM, Norby B. et al. Evaluation of serum cobalamin concentrations in dogs of 164 dog breeds (2006–2010). J Vet Diagn Invest 2012; 24 (06) 1105-1114 44 Spillmann T, Wittker A, Teigelkamp S. et al. An immunoassay for canine pancreatic elastase 1 as an indicator for exocrine pancreatic insufficiency in dogs. J Vet Diagn Invest 2001; 13 (06) 468-474 45 Spillmann T, Wilberg ME, Teigelkamp S. et al. Canine faecal pancreatic elastase (cE1) in dogs with clinical exocrine pancreatic insufficiency, normal dogs and dogs with chronic enteropathies. Eur J Comp Gastroent 2000; 5: 1-6 46 Battersby IA, Peters IR, Day MJ. et al. Effect of intestinal inflammation on fecal elastase concentration in dogs. J Vet Clin Pathol 2005; 34 (01) 49-51 47 Steiner JM, Rehfeld JF, Pantchev N. Evaluation of fecal elastase and serum cholecystokinin in dogs with a false positive fecal elastase test. J Vet Intern Med 2010; 24 (03) 643-646 48 Steiner JM, Williams DA. Serum feline trypsin-like immunoreactivity in cats with exocrine pancreatic insufficiency. J Vet Intern Med 2000; 14 (06) 627-629 49 Williams DA, Batt RM. Sensitivity and specificity of radioimmunoassay of serum trypsin-like immunoreactivity for the diagnosis of canine exocrine pancreatic insufficiency. J Am Vet Med Assoc 1988; 192 (02) 195-201 50 Waritani T, Okuno Y, Ashida Y. et al. Development of a canine trypsin-like immunoreactivity assay system using monoclonal antibodies. Vet Immunol Immunopathol 2002; 87 (1 – 2): 41-49 51 Steiner JM, Finco DR, Williams DA. Serum feline trypsin-like immunoreactivity (fTLi) in cats with experimentally induced chronic renal failure. J Vet Intern Med 2002; 16: 385 (abstract) 52 Wiberg ME, Lautala HM, Westermarck E. Response to long-term enzyme replacement treatment in dogs with exocrine pancreatic insufficiency. J Am Vet Med Assoc 1998; 213 (01) 86-90 53 Parambeth JC, Fosgate GT, Suchodolski JS. et al. Randomized placebo controlled clinical trial of an enteric coated micro-pelleted formulation of a pancreatic enzyme supplement in dogs with exocrine pancreatic insufficiency. J Vet Intern Med 2018; 32 (05) 1591-1599 54 Snead E. Oral ulceration and bleeding associated with pancreatic enzyme supplementation in a German shepherd with pancreatic acinar atrophy. Can Vet J 2006; 47 (06) 579-582 55 Rutz GM, Steiner JM, Williams DA. Oral bleeding associated with pancreatic enzyme supplementation in three dogs with exocrine pancreatic insufficiency. J Am Vet Med Assoc 2002; 221 (12) 1716-1718 1714 56 Pidgeon G. Effect of diet on exocrine pancreatic insufficiency in dogs. J Am Vet Med Assoc 1982; 181 (03) 232-235 57 Suzuki A, Mizumoto A, Rerknimitr R. et al. Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic insufficient dogs. Gastroenterology 1999; 116 (02) 431-437 58 Biourge V, Fontaine J. Exocrine pancreatic insufficiency and adverse reaction to food in dogs: a positive response to a high-fat, soy isolate hydrolysate-based diet. J Nutr 2004; 134: 2166S-2168S 59 Westermarck E, Wiberg ME. Effects of diet on clinical signs of exocrine pancreatic insufficiency in dogs. J Am Vet Med Assoc 2006; 228 (02) 225-229 60 Berghoff N, Suchodolski JS, Steiner JM. Association between serum cobalamin and methylmalonic acid concentrations in dogs. Vet J 2012; 191 (03) 306-311 61 Toresson L, Steiner JM, Suchodolski JS. et al. Oral cobalamin supplementation in dogs with chronic enteropathies and hypocobalaminemia. J Vet Intern Med 2016; 30 (01) 101-107 62 Toresson L, Steiner JM, Spodsberg E. et al. Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations. Vet J 2019; 243: 8-14 63 Toresson L, Steiner JM, Spodsberg E. et al. Effects of oral cobalamin supplementation on serum cobalamin concentrations in dogs with exocrine pancreatic insufficiency: A pilot study. Vet J 2021; 269: 105619 64 Texas A & M University. Veterinary Medicine & Biomedcial Sciences: Cobalamin information. Im Internet (Stand: März 2021): https://vetmed.tamu.edu/gilab/research/cobalamin-information/ 65 Parkinson S, Tolbert K, Messenger K. et al. Evaluation of the effect of orally administered acid suppressants on intragastric pH in cats. J Vet Intern Med 2015; 29 (01) 104-112 66 Pilla R, Gaschen FP, Barr JW. et al. Effect of metronidazole on the fecal microbiome and metabolome in healthy dogs. J Vet Intern Med 2020; 34 (05) 1853-1866 67 Barko PC, McMichael MA, Swanson KS. et al. The gastrointestinal microbiome (Review). J Vet Intern Med 2018; 32: 9-25 68 Ziese AL, Suchodolski JS, Hartmann K. et al. Effect of probiotic treatment on the clinical course, intestinal microbiome and toxigenic Clostridium perfringens in dogs with acute hemorrhagic diarrhea. PloS One 2018; 13 (09) e0204691 69 Rossi G, Pengo G, Caldin M. et al. Comparison of microbiological, histological and immunomodulatory parameters in response to treatment with either combination therapy with prednisone and metronidazole or probiotic VSL#3 strains in dogs with idiopathic inflammatory bowel disease. PLoS One 2014; 9 (04) e94699 70 Roth N. Exokrine Pankreasinsuffizienz bei Hunden: Toleranz- und Wirkungsstudie mit Pankreatin (Albrecht), retrospektive Untersuchungen zur Prognose und Überlebenszeit [Dissertation]. Gießen: Justus-Liebig-Universität; 2010 Supplementary Material Supplementary Material References